Biomedical subjects
Publications and source records attributed to E Hayes.
A series of methyl-substituted 1,2,3,4-tetrahydrocarbazoles was synthesized and screened for in vitro activity against tyrosine hydroxylase and dopamine-beta-hydroxylase. The most potent compounds were evaluated for inhibition of norepinephrine biosynthesis in rats. The results indicated no significant decrease in norepinephrine levels at three dosage levels.
Patients with mucopolysaccharidoses are frequently hard of hearing. This disorder is often conductive in nature and considered the result of chronic serous otitis media. Such patients frequently undergo myringotomy. A coexisting progressive neurosensory hearing loss in some children is recognized far less often. Examination of temporal bones in such patients suggests arrested development including incomplete pneumatization. Hair cell dysfunction is implicated in the neurosensory component. Close communication among pediatrician, otolaryngologist, and speech and hearing personnel is essential to maximize the communicative skills of these patients.
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The XYY complement appears to be more common in individuals with nodulocystic acne than in those without acne. Consequently, nodulocystic acne may prove to be a useful adjunct to height as an easily recognizable, phenotypic feature of the XYY syndrome.
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Symptomatic HIV infection was first diagnosed in an Irish child in 1985. A prospective study was initiated to determine the vertical transmission rate (VTR) of HIV and the average age of infant seroreversion and to monitor clinical, immunologic and virologic evidence for HIV infection in seroreverters. Ninety three HIV positive infants have been prospectively identified since 1985. The predominant underlying maternal risk factor for HIV infection is intravenous drug use (IVDU) (96 per cent). Of 93 infants, median gestational age was 40 weeks and median birth weight 3125 grams. Ninety-four per cent of infants were bottle fed. Currently 72 (77 per cent) infants are uninfected, 12 (13 per cent) are infected, 4 (4.5 per cent) are indeterminate and 5 (5.5 per cent) have been lost to follow up. The intermediate estimate of vertical transmission rate (VTR) is 14.3 per cent. The median age at documented seroreversion was 12 months. There are no significant differences between infected and non-infected children in male/female ratio, gestational age, mode of delivery or birth weight. Strategies to reduce the transmission of HIV among drug users in combination with routine antenatal screening and antiretroviral prophylaxis of vertical transmission are all measures which can reduce HIV infection in our children.
During February and March of 1998, 12 sudden deaths were reported among residents of a high-Andean community in Ecuador. All 12 fatalities were members of the same extended family and some had apparent exposure to sick guinea-pigs. Following an initial investigation by public health officials, an additional death was reported in a nearby community in April, also associated with exposure to sick guinea-pigs. Blood samples from humans, dogs, and a rodent were tested for antibody to the F1 antigen of Yersinia pestis by passive haemagglutination assay. Tissue from rodents was subjected to direct fluorescent antibody staining using fluorescein-labelled monoclonal antibody to Y. pestis F1 antigen. Formalin-fixed specimens from the 2 autopsies were evaluated using a 2-step alkaline phosphatase immunoassay with a monoclonal antibody to Y. pestis F1 antigen, and tissues that had not been embedded in paraffin were tested for the presence of DNA encoding the F1 structural antigen by polymerase chain reaction. Serological evaluation of close contacts of the fatalities revealed positive titres to F1 antigen of Y. pestis, the aetiological agent of plague, in 3 contacts from the first community and 1 from the second. Immunohistochemical staining of tissues collected from 2 of the fatalities provided evidence that both had pneumonic plague. Five of 14 dogs found in the communities were seropositive for plague antibody, providing evidence of a recent epizootic plague in the area.
The clinical and radiological findings in a 71-year-old woman with a metastatic renal cell carcinoma to the right nasal cavity are presented. The kidney tumor manifested clinically as epistaxis. Computed tomography revealed an expansile lesion in the right nasal cavity with extension to the right antrum, right ethmoid sinus, and left nasal cavity. There was no lytic bone destruction, but there was displacement of bone caused by the expansile tumor mass.
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A comparison between blood glucose levels in patients attending a diabetes clinic and in the same patients leading their normal lives showed that for maturity-onset diabetic patients on oral hypoglycemic therapy, the clinic levels were a poor guide to the patients' usual blood glucose. For insulin-treated patients and for those treated with diet alone, the clinic levels were not significantly different from those taken at home or work.
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In this article, the authors describe the concept of workplace advocacy, workplace hazards experienced by hospital nurses, methods for teaching workplace advocacy behavior, and strategies for controlling specific workplace hazards. Workplace advocacy is a universally applicable concept for maintaining professional nursing practice. Staff development educators are key in helping staff nurses achieve autonomous nursing practice.
The authors examine the effectiveness of using hospital discharge data in assessing trends and geographic variations in the occurrence of selected chronic diseases. The Chronic Disease Surveillance System, in place from 1987 to 1991, used hospital discharge data, and Cancer Registry data to tract selected chronic diseases. The authors reviewed data on three diseases: breast cancer, cervical cancer, and lung cancer. A computerized algorithm was used to link multiple records representing a single disease occurrence. To estimate disease occurrence rates from hospital discharge data, repeat admissions for the same disease in any given calendar year were discounted. All rates were directly age-adjusted to the 1985 Maine state population. For all three diseases, the rates obtained from hospital discharge data were higher than Cancer Registry rates. Possible causes for the discrepancies and suggestions for improving the utility of hospital discharge data for chronic disease surveillance are discussed.