Search PubMed⌕ Search

Biomedical subjects

E Hausmann

Publications and source records attributed to E Hausmann.

At least 37 records · Page 2Linked to original sources

Analytical methodology in quantitative digital subtraction radiography: analyses of the aluminum reference wedge.

An aluminum wedge can be used to quantify volumetric change in crestal alveolar bone which has been identified through subtraction radiography. This study compares two methods for using an aluminum wedge for this purpose: 1) the aluminum wedge is present in both radiographs and used to determine the aluminum equivalent bone density present in the region of change for each radiograph; and 2) the aluminum wedge is present in only one radiograph and the difference image of the wedge in the subtraction image is used to calculate the aluminum equivalent change in bone density. Pairs of standardized x-rays were taken with synthetic bone chips of known weights placed when the second x-ray was taken. The volumetric change produced by the bone chips was calculated by the two methods. The relationship of the calculated volumes to the chip weights had a higher r2 value (P < 0.05) for the two-wedge method than for the one-wedge method. The two-wedge method is recommended for volumetric quantification of alveolar bone change. The influence of the clarity of the aluminum wedge image in the x-ray pairs was also examined in this study and found to be significant. Attention must be given to factors which affect the aluminum wedge image characteristics to achieve optimal results.

Aluminum↗

Validation of quantitative digital subtraction radiography using the electronically guided alignment device/impression technique.

The electronically guided alignment device (EGAD) has been demonstrated to function well with a custom fabricated stent for taking radiographs for subtraction. The objective of this study is to demonstrate that this device functions well when used with an impression bite-block rather than a full arch acrylic stent. Nineteen subjects participated. Two vinyl siloxane impressions were made for each subject and a pair of x-rays was taken with each impression. The location for study was divided among 7 for the maxillary premolar-1st molar region, 6 for the mandibular premolar-1st molar region, and 6 for the incisor-canine region. To simulate bone change 3 bone chips (approximately 1, 7, and 10 mg) were positioned in the mucobuccal fold when one of each pair of x-rays was taken. Pairs of radiographs were subtracted and the bone change (chips) isolated by thresholding to determine their area. An aluminum ramp was used to determine volume. A strong linear relationship between actual chip weight and equivalent aluminum volume (r2 = 0.64, P < 0.001) was obtained for all regions of the mouth when considered together. The strongest relationship of the 3 regions was for mandibular premolar-1st molar sites, r2 = 0.78. These data indicate that the EGAD/impression technique is suitable for taking radiographs in all areas of the mouth for quantitative digital subtraction.

Adult↗

Model fit and measurement outcome in attachment measurements: a simulation study.

Serial attachment level measurements were simulated based on 2 hypothetical models of true change: 1) a burst model, where attachment changes rapidly over the duration of one measurement interval, but is unchanging before and after, and 2) a linear model, where attachment changes at a constant rate over time. Normally distributed measurement error was added to the modeled attachment level change to produce the series of measurement simulations. It was then determined for each series whether a burst model or a linear model best fit the simulated measurement series for a range of overall attachment level changes. For series generated by a burst model, the burst model fit better than a linear model a significant proportion of the time at all attachment level changes. However, for series generated by a linear model, the burst model provided the best fit for attachment level changes that were less than 4 times the standard deviation of the measurement error. Estimates of change based on a linear model slightly overestimated change when the true underlying model was a burst model. Estimates of change based on a burst model slightly underestimated change when the true model was a burst model, but substantially underestimated change when the underlying model was a linear model. Model fit when assessed by the least squares criterion may not be a reliable guide to model validity.

Bias↗

Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss.

This study examined the risk indicators for alveolar bone loss associated with periodontal infection. A cross-section of 1,361 subjects aged 25 to 74 years, from Erie County, NY were evaluated for interproximal alveolar bone loss and potential explanatory variables including age, gender, history of systemic diseases, smoking, and presence of 8 subgingival bacteria. Interproximal alveolar bone loss was measured from the alveolar crest to the CEJ and a mean computed for each subject. The mean bone loss per subject (BL) ranged from 0.4 to 8.8 mm, and this outcome variable was grouped into 4 ordered categories. The degree of association between the explanatory variables and BL was examined utilizing an ordinal stepwise logistic regression model. Factors which were positively associated with more severe bone loss included subgingival colonization with B. forsythus (O.R. 2.52; 95% CI: 1.98 to 3.17) or P. gingivalis (O.R. 1.73; 95% CI: 1.27 to 2.37), race (Native American, Asian, or Pacific Islanders) with an O.R. 2.40 (95% CI: 1.21 to 4.79), and gender with males having higher odds than females. Smokers had greater odds for more severe bone loss compared to non-smokers ranging from 3.25 (95% CI: 2.33 to 4.54) to 7.28 (95% CI: 5.09 to 10.31) for light and heavy smokers, respectively. Individuals at older ages also showed more severe levels of bone loss. History of kidney disease (O.R. 0.55; 95% CI: 0.35 to 0.89) and history of allergies (O.R. 0.76; 95% CI: 0.59 to 0.98) were inversely associated with severity of bone loss.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Effects of small angle discrepancies on interpretations of subtraction images.

The present study examines interpretations of subtraction images of pairs of radiographs taken at 0 degrees, 1 degree, or 2 degrees of angle discrepancy. The radiographs were taken at each of 48 alveolar crestal sites on 15 dried human skulls. Computer-simulated lesions were induced at the sites on three fourths of the radiographs. Ten instructed dentists were asked to interpret the subtraction images as to the presence or absence of crestal change. A 2-degree angle discrepancy between radiographs resulted in a significant difference in sensitivity from that of radiographic pairs with a 0-degree discrepancy. However, we found no significant difference in sensitivity between 1-degree and 0-degree pairs of radiographs. In conclusion, a 1-degree geometric difference between pairs of radiographs does not significantly contribute to errors in interpretation of subsequent subtraction images.

Alveolar Bone Loss↗

Detection of experimentally induced lesions in subtraction images of cancellous alveolar bone.

Cancellous bone lesions of varying sizes were made in specimens of human mandibles and radiographed under geometrically reproducible conditions and observed by viewing of before and after radiographs and subtraction images. Of 178 lesions, traditional comparison of before and after radiographs resulted in 108 correct diagnoses. Analysis of the same lesions by subtraction radiography resulted in 162 (91%) correct diagnoses. This difference in diagnostic accuracy with the use of these two methods of radiographic analyses was significant at the p = 0.0001 level.

Alveolar Bone Loss↗

Algorithm for the automated alignment of radiographs for image subtraction.

The results of this study indicate that automated alignment of pairs of radiographs produces subtractions that are indistinguishable in quality from subtractions aligned manually by an experienced aligner. In developing the algorithm for automated alignment, care was taken that the criteria used for establishing a window appropriate for testing the quality of alignment were the same for both alignment techniques.

Algorithms↗

Studies on the relationship between changes in radiographic bone height and probing attachment.

The aim of this investigation was to determine the relationship between loss of radiographic crestal bone height and probing attachment loss. As part of this aim, we are introducing a new method for determination of a threshold for significant probing attachment loss which takes into account the error contributed by alteration in tissue tone. 57 adults with established periodontitis were selected. Radiographs were taken using the Rinn alignment system. Crestal change was determined from bone height measurements on digitized images of pairs of radiographs using the "side-by-side" technique of analysis developed recently by us. Probing attachment loss was measured using the Florida electronic probe system. Radiographic and probing measurements were made at baseline and after 1 year. No treatment was given during this period. A direct and significant relationship was observed between radiographic bone loss and probing attachment loss on a site basis (p = 0.0001, r2 = 0.018) and between subject means (p = 0.0014, r2 = 0.16). Radiographic and probing attachment change at all categories of sites, dichotomously classified as to not changing or loosing indicated 13% of sites were loosing by measurement of radiographic change and 9.6% were loosing by measurement of attachment change. Concordance in radiographic and attachment level change was found in 82% of sites examined. The relative diagnostic import of change in probing attachment or change in radiographic bone height requires treatment outcome studies based on use of diagnostic information of the 2 measuring techniques used singly and in combination.

Adult↗

Studies of the angular reproducibility of positioning patients adjacent to an x-ray tube: 1. Stent-rod based and extra-oral systems.

The usefulness of subtraction radiography for detecting small changes in crestal bone is dependent upon achieving reproducible geometry between x-ray beam and patient structures when serial radiographs are taken. This study evaluates 2 methods currently employed to maintain geometric correspondence: 1) a stent-based system which rigidly fixes a custom-made stent to the x-ray tube by the use of a rod and 2) an extra-oral system which positions a patient in the x-ray unit by means of ear rods. The projection of a light beam from a fixed subject reference was used to measure the change of the orientation of the reference at 2 different measurement times. The rod-stent system was able to maintain a discrepancy of less than 2 degrees 75% of the time over a time period of 6 months. For the extra-oral system this ranged from 72% to 92% during a 1-month period.

Alveolar Bone Loss↗

Evaluation of a simple modified radiographic alignment system for routine use.

Radiographic frames used for longitudinal studies may be in part unreadable for measuring crestal bone change. Sites may not be present on the film, or the measurement reliability may be compromised because of dissimilar geometry. Several techniques used to address this problem are expensive, time-consuming, and required great skill. For the present study a commercially-available alignment system was simply modified by addition of a reference pin in the bite block, facilitating the repositioning of the film holder for a second exposure. This study determined the ability of the modified instrument to: 1) improve the geometrical correspondence between serial radiographs; and 2) reduce the frequency of missed sites in the film. Two pairs of x-rays were taken for each of 40 subjects, 1 pair with the standard alignment instrument of an assigned site and 1 pair with the modified instrument of the contralateral site. Measurements of alveolar bone height were performed using the "side by side" technique. The modified instrument yielded significantly smaller measurement differences and a significantly better geometrical correspondence than the conventional system (P < 0.05). Also, the modified instrument yielded significantly greater (P < 0.01) readable sites (86%) as compared to the conventional instrument (62%). The simply-modified instrument facilitates the correct interpretation of serial radiographs.

Acrylic Resins↗

Alternative methods for screening periodontal disease in adults.

Clinical measurements of periodontal attachment loss, while not always representing the histological changes, are used to establish the diagnosis of adult periodontitis. Such measurements are difficult to perform accurately and are labor intensive. To counter these problems, index teeth and index sites have been employed in an attempt to estimate the severity of the periodontal condition without the need to resort to elaborate attachment measurements. Unfortunately, such indices usually tend to underestimate prevalence while often overestimating severity. The purpose of the present study was to examine the correlation of alternative clinical, radiographic and microbiological parameters, with periodontal disease using the diagnostic criteria of established periodontitis. 508 adults included in this study received thorough periodontal examination which included probing pocket depth, clinical attachment level, plaque, gingival and calculus scores, together with radiographic analysis and assays of subgingival periopathogenic microorganisms. Radiographic alveolar bone loss and probing pocket depth had the highest correlation with clinical attachment loss (phi = 0.72 and phi = 0.75 respectively). Plaque scores (phi = 0.17), like gingival scores (phi = 0.06) and calculus scores (phi = 0.42) had poor correlation with established periodontitis. Periodontopathogenic species demonstrated high specificity and negative predictive values; but low sensitivity and positive predictive values make for an overall low correlation of these species with established periodontitis. However, when used in a logistic regression model, the presence of P. gingivalis (odds ratio = 6.25) has shown to contribute significantly to the estimate of probability for established periodontitis. The use of these various alternative parameters for screening of periodontal disease is discussed in light of their sensitivity, specificity and predictive value.

Adult↗

Periodontal status of women taking postmenopausal estrogen supplementation.

The association between supplementary estrogen intake and periodontal and gingival status in a total of 228 women 50 to 64 years of age was examined. Clinical parameters including visible supragingival plaque, subgingival calculus, probing pocket depth, clinical attachment level, alveolar bone height measurements, and number of remaining teeth were measured. Gingival status was recorded as gingival bleeding after gentle manipulation. Selected periopathogens, socio-economic, demographic, smoking habits, and health care variables were assessed. Gingival bleeding was significantly lower in the estrogen supplement group (n = 57) compared to the control group (n = 171) (P = 0.009); the estrogen group also exhibited significantly lower visible plaque levels (P = 0.030) and fewer Capnocytophaga-ssp. (P = 0.032). Dental care was more frequent (P < 0.001), and education levels were higher (P = 0.022) in the estrogen group. To investigate whether differences among the above parameters contributed to the difference in gingival bleeding, an age-adjusted analysis of covariance (ANCOVA) was used. The final ANCOVA indicated non-significant relationships for all parameters examined except estrogen intake (P = 0.044). Women taking estrogen exhibited lower gingival bleeding than the control group after correcting for these factors. The results indicate that estrogen supplementation is associated with less gingival bleeding in women aged 50 to 64, as compared to an age-matched control group.

Aged↗

Effect of x-ray angulation on radiographic periodontal ligament space width.

The aim of this study was to set up a model for quantitating a change in radiographic PDL width on variation of x-ray angulation within anticipated clinical limits. Four incisor and 4 molar sites of 6 human skulls were radiographed at varying angulation. Horizontal angulation changes were made over a 12 degrees range, in 3 degrees increments. Vertical angulation change was in one 10 degrees increment. Baseline radiographs were taken with the x-ray beam perpendicular to a buccal tooth surface in a horizontal direction and perpendicular or 10 degrees off the perpendicular in a vertical direction. The radiographs were converted to digitized images and PDL width measurements made utilizing a mouse-driven computer program. The mean PDL width differences between all possible horizontal and vertical combinations (n = 45) were compared with the mean of those obtained from differences observed in PDL width measurements on replicate baseline radiographs. Mean PDL width differences for incisor locations were statistically different from the mean baseline PDL width difference; posterior PDL width difference showed no statistical variation from the mean baseline PDL width difference. For radiographs taken within the range expected under clinical conditions, a significant change in PDL width may be observed in incisor locations. Posterior sites may not exhibit this significant change due to the anatomy of the region which may reduce the clarity of the radiographic image.

Humans↗