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Biomedical subjects

E Hasler

Publications and source records attributed to E Hasler.

5 recordsLinked to original sources
PubMed1991

A comparison of knee extensor strength curves obtained theoretically and experimentally.

Strength curves relate a measure of maximal voluntary force of a group of synergistic muscles, typically a resultant knee joint moment, to a measure of muscular length, typically a joint angle. In this study, it was hypothesized that the shape of strength curves is primarily determined by the force-length properties of the individual muscles within a synergistic group. This hypothesis was tested for knee extensor strength curves by comparing theoretically determined strength curves based on the force-length relations of the individual muscles with those obtained experimentally. The agreement between theoretical and experimental curves was good, suggesting that the initial hypothesis was correct. Accepting this result, it is possible to determine the contribution of individual muscles to the total force of the synergistic group. This information, in turn, may be utilized for practical applications in sports or for evaluating strength curves of patients with injuries or diseases of the musculoskeletal system.

Adult↗
PubMed1977

[The CEA test and other immunological tests as disease course controls in gastrointestinal adenocarcinoma].

161 patients with adenocarcinoma of the gastrointestinal tract were studied to determine the value of the CEA test and a battery of non-specific immunological tests during the course of the disease. The ability of these tests to detect a tumor recurrence in radically operated patients was evaluated. A false negative preoperative CEA value was found in 40% of the patients with gastric carcinoma and 32% with colorectal carcinoma. Patients with a negative preoperative CEA value, and those with only slightly elevated values, had a distinctly better prognosis regarding initial operability and tendency to postoperative recurrence than patients with primarily markedly elevated values. With few exceptions, the development of distant metastases was detected earlier and more easily with the CEA test than by the usual routine follow-up methods. However, in the event of isolated local recurrence the CEA test was positive in only 1 of 5 patients. This reflects the direct correlation between tumor size and CEA elevation. The CEA test is a valuable supplement in the follow-up of patients with gastrointestinal carcinoma.

Adenocarcinoma↗
PubMed1977

[VP 16-213 in combination with endoxan, methotrexate and oncovin as polychemotherapy for bronchogenic carcinoma].

Thirty patients with bronchogenic carcinoma underwent an 8 week course of induction therapy consisting of cyclophosphamide, methotrexate, vincristine, and VP 16-213 (NSC 141 540). Those who achieved objective remission or tumor stabilization were then placed on an intermittent treatment schedule with the same drugs. Of the 30 patients, 17 had an objective response, 5 were unchanged and 8 progressed. Responses were more frequent in anaplastic carcinoma (13/19) than epidermoid or adenocarcinoma (4/11). The toxicity mainly consisted of leukopenia, thrombopenia, alopecia, nausea and vomiting. The implications of these findings in the planning of further chemotherapeutic programs are discussed.

Adenocarcinoma↗
PubMedDate not supplied

A combination of cyclophosphamide, methotrexate, vincristine and VP 16-213 (NSC 141 540) in the treatment of bronchogenic carcinoma.

Thirty patients with bronchogenic carcinoma were treated with an 8-week induction therapy consisting of cyclophosphamide, methotrexate, vincristine and VP 16-213 (NSC 141 540). Those who achieved objective remission of tumor stabilization were then placed on an intermittent treatment schedule with the same drugs. Of the 30 patients, 17 had an objective response, 5 remained without change, and 8 progressed. Responses were more frequent among anaplastic (13/19) than epidermoid or adenocarcinoma (4/11). The toxicity consisted mainly of leucopenia, thrombopenia, alopecia, nausea and vomiting. The implications of these findings in the planning of further chemotherapeutic programs are discussed.

Alopecia↗