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Biomedical subjects

E Halberstadt

Publications and source records attributed to E Halberstadt.

At least 37 records · Page 2Linked to original sources
PubMed1980

[The behaviour of endocrinal parameters under prophylaxis of hyaline membrane disease with glucocorticoids (author's transl)].

Prevention of hyaline membrane disease with glucocorticoids produces suppression of the hypopituitary-adrenocortical axis of the mother as well as of the foetus. The extent of the suppression is significantly higher under medication with the 9 alpha-fluorinated preparations, betamethasone and dexamethasone, than under medication with 16-methyleneprednisolone. Increases in the concentration levels of the mineralocorticoid DOC are to be expected in 37% to 50% of the patients, depending on the administered corticoid. The percentage of increase is 150% under 16-methyleneprednisolone and 220% under betamethasone and dexamethasone.

Adrenal Cortex Hormones↗
PubMed1979

[Biochemical maturation of organs in the foetus and its induction (author's transl)].

Several biophysical and biochemical changes are prerequisites for the adaptation of the newborn to extrauterine life. Enzyme induction is the mechanism on which this adaptation of metabolism is based. The theoretical fundamentals of enzyme induction are presented, and the perinatal origin of enzymes explained by means of the example of PEP carboxykinase. Among the mose frequent disturbances of the maturing of organs are hyperbilirubinaemias and the respiratory distress syndrome of newborn. The biochemical and physical concepts underlying these disease pattens are explained, and possibilities of enzyme induction and hence acceleration of maturity are shown. On the grounds of clinical experience, enzyme induction appears to be safely established as a membrane prophylaxis.

Adaptation, Physiological↗