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Biomedical subjects

E Haas

Publications and source records attributed to E Haas.

At least 91 records · Page 5Linked to original sources
PubMed1978

Some aspects of epidemiology of resurgent malaria in Turkey.

The resurgence of autochthonous Plasmodium vivax malaria in Turkey is a matter of considerable concern. Anopheles sacharovi is the important vector but other species, notably A. superpictus, may play a role in transmission. The epidemiology is discussed in terms of factors related to the mosquito, factors related to the human host and human ecology as it affects dispersal of the parasite. Although the development of insecticide resistance is grave, the present situation is mainly attributable to operational deficiencies stemming from administrative and financial constraints.

Animals↗
PubMed1978

[Endolaryngeal microsurgery. A report of our experiences in the years from 1966 to 1976 (author's transl)].

The total of 1420 mikrolarynagoscopic operations during the past 11 years have been epicritically evaluated by the authors. Besides obtaining a disclosure of the various diseases, the question of an early diagnosis of glottis cancer an its preceeding illnesses was discusses. With available case histories, the authors could determine a definite increase in the early stages of the comprehensive glottic carcinoms. The observed optimation of an early diagnosis has been related back to a reduction of the prediagnostic ailment intervals and the consequent prognomatic use of the endolaryngeal microdiagnoses. Considering the possibility of complication during the microlaryngological operation, a critical position was taken to the question of indications, and the diagnostical value of microskopic laryngoskopic as well as the stroboskopic in reference to the early diagnosis of malignant glottic changes were discussed. The authors have come to the previously presented interpretation that with malignantly suspicios appearance a histomorphological clarification by process of endolaryngial microdiagnosis cannot be waived.

Adult↗
PubMed1977

[Basic techniques of plastic surgical repair in defects of the skull and face (author's transl)].

Ommitting historical datas, ancient theories and old-fashioned surgical techniques, the author gives a summary of current plastic surgery in the head and neck. After a review of aesthetic charateristics of the face, basic principles of surgical skin closure and different forms of local and distant flaps are discussed. Emphasis in placed on tissue transplanation. The biological problems in transplanatation of skin, subcutaneous and supporting tissues, using autografts, allografts and xenografts are mentioned in addition to several methods of concervation. The clinical importance of various autogenous supports used for transplantation to the skull and face is stressed. Concerning foreign implants, the author discusses the problem of the so-called foreign-body sarcoma and the foreign-body reaction to synthetic and metallic implants. Indications for using synthetic implants are mentioned. Microsurgical techniques seem to be important for further development of facial plastic surgery.

Bone Plates↗
PubMed1977

Partial purification of human renin.

An affinity gel for the purification of renin was prepared by coupling pepstatin to aminohexylagarose gel. Partially purified human renin (Haas et al., Arch. Biochem. Biophys., 110, 534-543, 1965) was purified further by affinity chromatography on the pepstatin-aminohexyl-agarose gel, gel filtration on a Sephadex G-75 column, and ion exchange chromatography on a DEAE-cellulose column. Separation from a protease permitted further purification without progressive loss of activity. Three peaks of enzymatically active renin were obtained after the DEAE-cellulose chromatography, with specific activities ranging from 206 to 166 and 85 Goldblatt units/mg protein, respectively. The specific activity of 206 GU units/mg represents a 103,000-fold purification compared to the renin present in the first crude extract.

Chromatography, Affinity↗
PubMed1977

[The diagnostic and therapeutic possibilities of endolaryngeal microsurgery (author's transl)].

The technique and types of anesthesia for endolaryngeal microsurgery are described, utilizing a personal series of 1283 procedures which were performed over a preceding ten-year period. The great diagnostic value of this method of examination for the early diagnosis of glottic carcinoma is shown. 54.4% of all endolaryngeal microsurgical operations performed were used for the diagnosis, therapy and control of tumors. The remaining 45.6% of cases were undertaken to eliminate benign voice=disturbing processes. The indications for surgery are discussed, with note given to the low complication rate associated with such surgery.

Catheterization↗
PubMed1976

The fluorescence decay of human serum albumin and its subfractions.

Human serum albumin does not decay monoexponentially although it contains a single tryptophan residue per molecule. The molecular population is thus heterogeneous with respect to the tryptophan emission. The separated monomeric and dimeric molecules of this protein, as well as various fractions isolated by the procedures of Foster and his coworkers, exhibit deviations from monoexponential decay which are comparable to those of the unfractionated protein; thus, the heterogeneity in molecular population of human serum albumin persists in the various fractions. By comparing the fluorescence decay data of this protein in the presence of thyroxine with the corresponding quenching data it was found that the fluorescence of the protein does not respond uniformly to the binding for all protein molecules. Qualitatively similar behavior was found for bovine serum albumin. In view of the above, binding studies followed by fluorescence should be viewed as averages over a heterogeneous population of the molecules of the serum albumin.

Acetates↗
PubMed1976

The effect of main artery occlusion of one kidney on blood pressure of dogs.

Occluding the main artery of one kidney in each of six dogs resulted in an average increase in the renin concentration of the peripheral blood from the original 0.040 to 0.198 milliunit/ml of serum. During the same time (3-4 days), the occlusion also resulted in a significant rise of directly measured mean systemic blood pressure from an average basal level of 104 to 139 mm Hg.

Animals↗
PubMed1976

In vitro and clinical studies of cefatrizine, a new semisynthetic cephalosporin.

Cefatrizine, a new oral semisynthetic cephalosporin, was evaluated in vitro and in the treatment of 18 patients with acute urinary tract infection, pneumonia, and soft tissue infection. In vitro, it was more active than cephalexin for gram-positive and gram-negative bacteria. It was also more active than cephalothin, cefazolin, and cephapirin against most of the gram-negative bacteria but less active against the gram-positive bacteria. Of the patients treated with cefatrizine, only one failed to respond. This patient had pneumococcal conjunctivitis and hypogammaglobulinemia and neutropenia. The mean peak serum level after multiple 6-hourly doses of 500 mg was 6.2 mug/ml. The serum levels of cefatrizine necessary for inhibition of most susceptible organisms were well within the achievable range. The drug was well tolerated, and no renal, hepatic, or hematological toxicity was detected.

Administration, Oral↗
PubMed1976

Reconstruction of the ala nasi and the lateral wall of the nose.

With reference to the functional importance of the vestibular region, it is recommended that only such operative methods should be practiced for the reconstruction of the ala nasi as take into account the aerodynamics of the vestibular region. The reconstruction of the cartilaginous infrastructure should therefore be an integrading component of the ala replacement. Various possibilities for the fulfilling of these requirements are pointed out and a pedicled septal mucosa-skin-cartilage flap described by the author which, in conjunction with a frontal skin flap permits the repair of the ala nasi in a shorter time is described in more detail. For the treatment of defects of the lateral nasal wall, in addition to the insular flap operation from the nasolabial region and the forehead, the medial frontal flap technique as described by Kazanjian is particularly recommended. This method is also suitable very particularly for closure of perforating defects in conjunction with the split skin graft.

Humans↗
PubMed1976

[Reconstruction of the nose by forehead skin flaps (author's transl)].

On introduction the advantages and disadvantages of forehead skin in reconstructive rhinoplasty are presented. The median frontal flap described by Kazanjian, a horizontal or slightly oblique frontal flap, the frontotemporal flap described by Schmid and the scalp flap described by Converse are discussed. After detailed description together with illustration of various techniques it is shown that each method can be used for specific indications. The choice of method by the less experienced is therefore facilitated. A. The median frontal flap is especially indicated for the grosser perforating defects of the external nose. B. The fronto-temporal flap is especially indicated for subtotal or total defects of the nasal alae, tip and columella of the younger patients who expects a good cosmetic result. C. The horizontal or slightly oblique frontal flap is especially indicated for subtotal or total defects of the nasal alae or tip of the older patient, who cannot undergo repeated surgery or prolonged hospitalisation. D. The frontal scalp flap is especially indicated for the grosser subtotal defects of the external nose.

Age Factors↗
PubMed1975

[Immediate one-stage total oesophagenal replacement by transmediastinal transposition of the stomach without thoracotomy in a case of hypopharyngeal carcinoma (author's transl)].

A case of hypopharyngeal carcinoma (in a 36-year-old man) is reported in which, after blunt dissection of the oesophagus via a posterior mediastinal tunnel without thoracotomy, the stomach was mobilized and its fundus anastomosed to the pharynx at the level of the vallecula. This form of oesophagectomy was first reported in 1936 by Turner for carcinoma of the thoracic oesophagus. Adopting this procedure in cases of carcinoma of the hypopharynx or cervical oesophagus (as recently reported) has as its main advantage the restoration of normal swallowing within a few days, as also took place in the described case.

Adult↗
PubMed1975

Distribution of end-to-end distances of oligopeptides in solution as estimated by energy transfer.

A homologous series of oligopeptides each containing at its ends a donor and an acceptor of electronic excitation energy was synthesized by the solid-phase method. N-5-(2-Hydroxyethyl)-L-glutamine was the repeating unit, and peptides containing 4, 5, 6, 7, 8, and 9 of these amino-acid residues were prepared. The chromophores naphthalene and dansyl, which were used as donor and acceptor, respectively, fulfil the conditions necessary for energy transfer according to the Förster mechanism. A distance corresponding to 50% efficiency of energy transfer, tro = 22 plus or minus 1 A, was calculated. The kinetics of fluorescence decay of an oligomer containing the naphthalene chromophore only could be described precisely by a monoexponential function. In contrast, the kinetics of the decay curves of the fluorescence of the donor of all of the oligomers containing both donor and acceptor, as measured in viscous solution, deviated markedly from monoexponential behavior. The deviation was interpreted in terms of the great number of different conformations that the various molecules of each of the oligomers attain in solution, leading to characteristic end-to-end distribution functions between the donor and acceptor. Numerical adjustment of the parameters of some of the previously proposed expressions to describe the end-to-end distribution enabled the reconstruction of the kinetics of the fluorescence decay of the donor with great precision. The end-to-end distribution functions for the various oligopeptides were thus evaluated.

Alanine↗