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Biomedical subjects

E H Roland

Publications and source records attributed to E H Roland.

24 records · Page 2Linked to original sources
PubMed1987

Periventricular leukomalacia: radiologic diagnosis.

Fifteen infants and children with clinical evidence of periventricular leukomalacia (i.e., spastic diplegia or quadriplegia and premature birth) were studied. Computed tomography (CT) scans of the brain demonstrated the following characteristic abnormalities: reduction in quantity of periventricular white matter, particularly at the trigone, deep and prominent sulci that abutted the ventricles without interposed white matter, and ventriculomegaly with irregular outline of the lateral ventricles. The location and severity of abnormalities on CT scans correlated well with the neurologic abnormalities observed at follow-up and the known anatomic location of periventricular leukomalacia. These observations demonstrate the diagnostic value of CT scanning for periventricular leukomalacia during late infancy and childhood. Although serial ultrasonography during the first weeks of life may be diagnostic of periventricular leukomalacia, it is of less value later. In contrast, CT scans obtained beyond 6 months of age can demonstrate a characteristic pattern of abnormalities that may be considered diagnostic of periventricular leukomalacia.

Encephalomalacia↗
PubMed1984

Methadone poisoning due to accidental contamination of prescribed medication.

Two infants presented with fever and signs of brainstem dysfunction, including impaired consciousness, miosis, absence of oculocephalic responses, respiratory depression and a very peculiar tremor of the tongue and floor of the mouth. They were found to have methadone poisoning caused by accidental contamination of prescribed antibiotics in the same pharmacy, which was a dispensing centre for a methadone maintenance program. They recovered with supportive treatment only.

Anti-Bacterial Agents↗
PubMedDate not supplied

Cortical visual impairment following birth asphyxia.

Visual defects are often poorly recognized in children with multiple neurologic problems due to perinatal hypoxic-ischemic encephalopathy. We report the clinical, radiologic, and electrodiagnostic characteristics of 20 children with cortical visual impairment secondary to birth asphyxia. Clinical diagnosis often was delayed. Ten patients recovered vision during the first two years of life. Four infants had coexisting damage to the pregeniculate visual pathway. Useful investigations included cranial computed tomography and visual evoked potential mapping. Electroencephalographic abnormalities were nonspecific. The classical definition of cortical blindness must be modified for children.

Adolescent↗
PubMedDate not supplied

Clinical features for prediction of survival in neonatal muscle disease.

Review of 17 newborns with muscle disease demonstrated that clinical features associated with survival beyond 1 year of age included gestational age of at least 35 weeks and requirement of mechanical ventilation for less than 21 days. In contrast, poor outcome was associated with Apgar scores below 5 at 5 min, pulmonary complications, arthrogryposis, or other congenital anomalies. The incidence of decreased fetal movements, polyhydramnios, hypotonia, and assisted delivery was not statistically different between infants who died early and those who survived beyond 1 year of age. Clinical features of newborns with muscle disease may be useful for prediction of outcome, especially when muscle biopsy abnormalities are nonspecific.

Biopsy↗