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Biomedical subjects

E H Jones

Publications and source records attributed to E H Jones.

At least 37 records · Page 2Linked to original sources
PubMed1985

HLA-DR7 association with African Burkitt's lymphoma.

Association between HLA-DR7 and Burkitt's lymphoma previously reported has been confirmed by a second study. Analysis of additional data from a second study of 33 Ghanaian patients with African Burkitt's lymphoma and 54 Ghanaian controls matched for age and ethnic origin showed that 39.4% of cases, but only 14.8% of controls, had HLA-DR7 (p less than 0.01). The relative risk of 3.7 is similar to that observed in the earlier study (3.3). Combining the earlier and present studies, analysis of clinical data from 94 patients with Burkitt's lymphoma and 116 controls shows the relative risk of Burkitt's lymphoma among individuals with HLA-DR7 was 3.4 (p less than 0.001). There was an increased relative risk of the disease associated with HLA-DR7 in: patients under 10 years of age; and patients with advanced stages of disease (Stage III or IV). However, comparison of relative risks by sequential analysis of 2 X 2 tables showed that these differences by age and stage were not statistically significant.

Adolescent↗
PubMed1985

Lymphocytotoxic antibodies in leukemic patients treated with bone marrow transplantation.

Lymphocytotoxic antibodies were studied sequentially in a series of 42 patients with leukemia who received a bone marrow graft. Of these patients, 38% had cytotoxic antibodies before bone marrow transplantation (BMT). After BMT the antibody status changed with time, but 62% of the patients had antibodies at some time after BMT. During the first 10 weeks after BMT, 40% of the patients had antibodies. Thereafter the frequency rose to 50% and remained at that level beyond one year after BMT. In successful grafts the gamma globulins are of donor origin six months after BMT; thus donor B cells are capable of forming lymphocytotoxic antibodies even when the immune system is suppressed by cyclosporine. The antibodies had recognizable HLA specificity in about half the cases before and after BMT. When donor and patient were HLA-identical, HLA specificity did not correspond to donor/recipient antigens. In two cases in which the donor was matched for only one haplotype, antibodies formed by recipient cells, active against donor HLA antigens, were found.

Antilymphocyte Serum↗
PubMed1981

Stimulation by CLL cells in mixed lymphocyte culture (MLC).

Cells from patients with chronic lymphocytic leukaemia (CLL) do not respond in the mixed lymphocyte culture (MLC) but are able to stimulate the response of normal lymphocytes. Mixed lymphocyte cultures were performed using cells from 24 patients with CLL and cells from 16 normal donors. The stimulatory capacity of 8 of these CLL cells was reduced when a common DR antigen was shared with the normal responding cell. We suggest that cells from certain selected CLL patients may be used in the mixed-lymphocyte reaction for determining the D-locus specificity of normal donors. CLL cells when expressed 1 DR antigen only, induced more clearly defined typing responses than cells with 2 DR antigens. There was no correlation between the ability of a CLL cell to induce a typing response and the T-cell status of the patient. However, a correlation with clinical course was suggested, because most cells which induced a typing response were obtained from patients who had received intensive treatment for the disease.

Aged↗
PubMed1981

Protozoan and viral infections of feral cats.

Identification of protozoan oocysts and serological tests were used to determine the prevalence of infections among 300 mainly adult feral cats in three different habitat types in south-eastern Australia. Oocysts of Isospora rivolta and Isospora felis were recovered from 3% and 4% respectively of 300 feral cat samples. Haemagglutination inhibition antibody to Toxoplasma gondii was detected in 20% of 75 cat sera tested. A high prevalence of specific antibody to feline panleukopaenia virus (79%) and feline calici virus (77%) was demonstrated but the prevalence of antibody to feline herpes virus was low (11%). 15 strains of feline calici virus were isolated from pharyngeal swabs. There were no other virus isolations from the 60 pharyngeal and rectal swabs taken. These viral and protozoan infections could not be linked with any obvious pathological conditions. Most cats were in good condition with light to moderate fat stores in depot areas. Limb fractures and other skeletal abnormalities occurred infrequently. Major tooth damage or absence of important teeth was evident in about 20% of 164 animals examined. There was no correlation between major tooth damage and poor body condition.

Animals↗
PubMed1981

Helminth parasites and arthropods of feral cats.

The prevalence (%) of helminth parasites in 327 mainly adult feral cats from 3 habitat groupings in Victoria and New South Wales was determined. The cestodes Taenia taeniaeformis (33%) and Spirometra erinacei (33%) were common; Dipylidium caninum was rate (2%). The nematodes Toxocara cati (28%), Cyathospirura dasyuridis and Cylicospirura felineus combined (27%) and Aelurostrongylus abstrusus (14%) were common but their prevalence differed markedly between habitats. Ollulanus tricuspis (5%), Gnathostoma spinigerum (less than 1%) and an Acanthocephala, Onicola sp (19%), also occurred. Arthropod parasites were collected from 204 of these cats, Ctenocephalides felis (16%) and Echidnophaga spp. (28%) were common. Spilopsyllus cuniculi (3%) and Ctenocephalides canis and Nosopsyllus fasciatus (less than 1% each) were rare. Other rare ectoparasites were the louse, Felicola subrostrata (4%), the mites, Otodectes cynotis, Cheyletiella sp and a trombiculid (less than 1% each); and the tick lxodes tasmani (less than 1%). There was no correlation between degree of parasitism and general condition of the cats.

Animals↗
PubMed1980

Study of the HLA system in Burkitt's lymphoma.

Seventy-eight patients with Burkitt's lymphoma and seventy controls from Ghana were typed for HLA-A, B, C and DR antigens, to determine whether there is an association between the HLA system and Burkitt's lymphoma. Increased relative risk was observed in Burkitt's lymphoma patients with DR7, HLA-A1 and B12(BW44).

Adolescent↗
PubMed1978

Antisera with Ia specificity selected by lymphocytes from patients with chronic lymphocytic leukemia.

Cells from patients with chronic lymphocytic leukaemia (CLL) have been used to screen the sera of pregnant women for antibodies specifc for B lymphocytes. The sera have been divided into groups showing Ig specificity: group I (UK 3) had a positive association with HLA-B8 and DW3, and group II (UK 2) with HLA-B7 and DW2. Groups III, IV and X were independent of each other and of HLA-A, B and C locus antigens. Certain sera with B-cell activity showed specific blocking activity in the mixed lymphocyte reaction (MLR), and this activity was dependent on the Ia sepcificities and DW specificities of cells used in the MLR. Some sera specifically blocked the responding cells, other the stimulating cells.

Antibody Specificity↗