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Biomedical subjects

E H Duthie

Publications and source records attributed to E H Duthie.

18 recordsLinked to original sources
PubMed1991

Patients in a persistent vegetative state attitudes and reactions of family members.

Patients in a persistent vegetative state (PVS) constituted approximately 3% of the population in four Milwaukee nursing homes. In order to understand family members' attitudes and reactions toward such patients, 33 (92%) of 36 family members of patients in PVS contacted were studied. The age of the patients ranged from 19 to 95 with a mean age of 73.4 +/- 17.2 years, and family members' ages ranged from 41 to 89 with a mean age of 61.8 +/- 3.3 years. The etiology of the PVS varied from dementia to cerebral trauma. The mean duration of the PVS was 54 +/- 8.4 months (range 12 to 204). Family members reported that they visited patients 260 times during the first year following the onset of the PVS and were still visiting at a rate of 209 visits yearly at the time of the interview. There was no significant correlation between the frequency of the family members visits and the duration of the PVS, the patient's or family member's age, or the family member's relationship to the patient. Ninety percent of patients were considered by family members to have some awareness of pain, light or darkness, environment, taste, verbal conversation, or the family member's presence. Most family members thought they understood the patient's medical condition, and the majority did not expect the patient to improve. Nevertheless, the majority of family members wanted the patient to undergo therapeutic interventions, including transfer to the acute hospital and surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

Activities of Daily Living↗
PubMed1991

Laboratory testing: current recommendations for older adults.

Efficient use of laboratory testing is essential in the care of the elderly, both for making accurate diagnoses and keeping costs in line. Further, primary care physicians treating the elderly need to have an understanding of the effect of age on laboratory values. Clinically significant change occurs with age in some values but not in others. This review focuses first on the effect of aging on different laboratory values and then discusses current recommendations for the most commonly used laboratory tests.

Aged↗
PubMed1991

Clinical characteristics of patients in the persistent vegetative state.

Little is known concerning the specific clinical characteristics of patients in persistent vegetative states (PVS). Fifty-one patients from four nursing homes, approximately 3% of the total patients, were identified as being in a PVS. The mean age of the patients was 64.8 +/- 3.2 years (range, 19 to 96 years) and the mean duration of the PVS was 3.3 +/- 5.0 years (range, 1 to 16.8 years), with 13 patients' PVS being longer than 5 years. Cerebrovascular accidents and dementia were the most common causes of the PVS, accounting for 32 of the cases (63%). In the younger patients cerebral trauma secondary to motor vehicle accidents was the most common cause. All 51 patients were fed via tube feeding and 35 patients had urinary catheters (75%). All patients were receiving daily medications, with greater than 50% taking daily vitamins. Over 30% were taking digitalis and/or diuretics and over 32% were taking H2 blockers. Transfer of patients to an acute care hospital was not uncommon, with 31 patients (61%) requiring 63 acute care hospitalizations during their stay in the nursing home. As expected, infections were the most common reason for acute care hospitalization, although 15 of the patients were hospitalized for surgical procedures. Another common problem encountered by the patients was pressure sores, with 78% of patients requiring specific therapy for at least one pressure sore. Surprisingly, only 27 (53%) of 51 patients had a specific resuscitation status designation in the medical chart, and neither presence of a chart designation nor specific resuscitation order was related to the patient's age or the cause or duration of PVS. From these data it would appear that clinical characteristics of patients in PVS are variable. Some patients are young, others are old. The cause varies from cerebrovascular accidents to cerebral trauma. Survival may be prolonged; complications are not uncommon, with some patients requiring acute care hospitalization.

Adult↗
PubMed1990

Thyrotoxicosis induced by topical iodine application.

We describe an elderly man who was admitted with congestive cardiac failure and found to have thyrotoxicosis. He did not have goiter, and he had normal radioiodine uptake in his neck. Serum iodine levels were elevated, explaining the lack of increase in radioiodine uptake in the thyroid gland. He had multiple pressure sores, which were treated with povidone-iodine (Betadine) soaks. Biochemical data were consistent with Graves' disease unmasked by topical iodine application. Povidone-iodine soaks are commonly used in decubitus ulcer care and warrant special attention in patients with preexisting thyroid disorders. We have reviewed the literature on this unusual complication.

Administration, Topical↗
PubMed1989

Falls.

Falls are a health hazard for the elderly patient. Annually, approximately 30 per cent or more of elderly patients will experience such a problem. Seventy per cent of deaths from falls occur in the elderly population. Morbidity from falls includes fractures, soft tissue trauma, anxiety about further falls, and loss of confidence. Falls are due to environmental factors; neurologic illness including dementia, drop attacks, and sensory loss; alcohol and drug use; orthostatis; cardiac arrhythmias; and acute illnesses such as infection, heart failure, and gastrointestinal bleeding. The physician who treats elderly patients needs to identify those patients at risk or those who already have the problem. Evaluation should not be limited to assessment for injury and must include establishing an etiology. Therapy depends upon determining the precise etiology for the fall and rectifying contributing factors.

Accidental Falls↗
PubMed1989

Coping with DRGs--a nursing home's experience.

The introduction of prospective payment system (PPS) based on diagnostic related groups (DRGs) has had a significant impact on hospitals. To determine the impact of PPS on nursing homes, the authors studied the activity of a Veterans Administration teaching nursing home (admissions, acute hospital transfers, and discharges) during 1 year preceding implementation of DRGs and for 3 consecutive years following implementation of DRGs. In 1983, pre-DRGs, a total of 36 patients, were admitted to the nursing home. Following implementation of DRGs, a sevenfold increase was noted in the number of patients admitted when comparing 1983 and 1986, with the monthly average of patients admitted increasing from 3 in 1983 to 9.7, 22, and 23.8 in 1984, 1985, and 1986, respectively. Associated with the increase in patients admitted following DRGs was an increase in patients requiring transfer to the acute hospital, within 30 days of admission to the nursing home. In 1986, approximately 27% of patients admitted to the nursing home required transfer to the acute hospital within 30 days of their admission. The number of patients discharged from the nursing home also increased following DRGs. None of the patients admitted to the nursing home in 1983 were discharged within 30 days of admission. Subsequent to introduction of DRGs, an average of two patients per month were discharged within 30 days of nursing home admission.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1989

Augmentation of influenza antibody response in elderly men by thymosin alpha one. A double-blind placebo-controlled clinical study.

Influenza remains a major cause of illness and death in elderly people despite current vaccination programs. One factor is an immunization failure rate in the elderly that may be as high as 50%. To test whether administration of thymosin alpha 1 would result in greater antibody production, we administered it (900 micrograms/m2 subcutaneously twice weekly for eight doses) in conjunction with the 1986 trivalent influenza vaccine. Ninety men (65-99 years old, mean age 77.3 years) were randomized double-blind to receive thymosin alpha 1 or placebo by the same schedule; the sera from 85 of these men were acceptable for analysis. The two groups were similar with respect to underlying disease, medications, and age. No toxicity was observed in either group. Antibody response rate was defined as a four-fold rise in antibody titer over 3-6 weeks following vaccination and was measured by an enzyme-linked immunosorbent assay (ELISA). Analysis was performed on treatment groups and subgroups divided by the mean age: the older group consisted of subjects aged 77 years and older, and the younger group those aged from 65-76 years. Baseline and change in absolute antibody levels were compared by t test and using age as a continuous variable by multiple regression analysis.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1988

Survey of nursing personnel attitudes toward infections and their control in the elderly.

To better understand nursing practice in geriatric care settings as it relates to infections, a survey of nursing attitudes about a variety of infection control issues was undertaken. Nurses were recruited from four settings: a university-affiliated, private nursing home (N = 46), a hospital-based nursing home (N = 33), a private nursing home (N = 20), and a home care agency (N = 26). The nurses appropriately recognized the importance of pneumonia and influenza as major threats to health in these settings and also reported some indifference regarding the notification of physicians about fevers under 38.9 degrees C (102.0 degrees F). Among the groups, similar attitudes about infection control principles were recorded, except that the ratings by the home care agency nurses were different from those of the institution-based nurses in the following areas: isolation as a means to prevent infection spread, proper waste disposal methods, and frequency of catheter change. Assessment of personnel attitudes and practices are important in detecting problems, guiding in-service programing, and revising care practices.

Aged↗
PubMed1988

Comparison of methods for calculation and depiction of incidence infection rates in long-term care facilities.

Assessment of changes in endemic infections in health care facilities are often based on comparison of infection rates over time. This study compared two methods for calculating and depicting infection data at a hospital-based nursing home care unit. Prospective incidence surveillance of nursing home acquired infections was conducted over a 12-month period, during which time denominator information on census and patient care days was also collected. Monthly infection rates were calculated based on (a) census (number infections per month/average monthly census), and (b) care duration (number infections per month/average monthly resident stay days). Results showed average monthly infection incidence of 27.4 episodes, (range 19-37), with average monthly census of 166.2 (range 160.0-180.0) and average monthly patient days of 5056 (range 4631-5583). The average census based monthly infection rate was 16.5 (range 11.9-22.4); average care duration based monthly infection rate was 5.4 (range 3.8-7.2) episodes per 1000 patient care days. Results indicate care duration based rates demonstrate less marked rate fluctuation than census based findings, and that duration based rates are more similar to values observed in acute care hospital nosocomial infection rates, thus are less likely to be misunderstood or misinterpreted by staff. Institutions should consider analyzing their methods for depicting infection data to provide consistency and clarity in data reporting.

Cross Infection↗
PubMed1988

Documentation and evaluation of fevers in hospital-based and community-based nursing homes.

We reviewed clinical evaluation practices and documentation of fever (greater than or equal to 100.2 degrees F) in all febrile patients over a two-month period in a hospital-based nursing home (HBNH) compared with a community-based nursing home (CBNH). Results showed 38 febrile (mean 101.9 degrees F) HBNH patients and 26 febrile (mean 101.5 degrees F) CBNH patients. Median time from fever onset to physician contact was 4 hours in HBNH and 12.5 hours in CBNH episodes (P less than 0.01). Laboratory studies were initially performed in 68% of HBNH and 31% of CBNH episodes (P less than 0.005), and diagnosis of fever source was documented in 76% of HBNH and 16% of CBNH episodes (P less than 0.005). Overall assessment stratification showed 81% febrile HBNH patients had both evaluation and therapy performed compared with 38% in CBNH (P less than 0.0001); 39% of febrile CBNH patients had no evaluation or therapy performed. Results indicate lack of documentation, and fever evaluation in CBNHs may preclude complete detection of nursing home-acquired infections and thereby hamper preventive responses to potential infection problems.

Adult↗
PubMed1988

Determining geriatric content in a medical school curriculum.

Geriatric content in a medical school curriculum was assayed by surveying faculty course directors and students about course content, by conducting an independent review of course content, and by analyzing the content of course examinations. The students' assessments of geriatric content were found to be not valid. Considerable variability was found in the amount of geriatric content within courses, and review of course examinations was found to be the most valid review method. Pharmacology and second-year psychiatry courses were shown to have the most coverage of geriatrics, while microbiology, biochemistry, and neuroanatomy courses were shown to have the least coverage of geriatric items. The geriatric items in the course examinations correlated strongly (r = .71) with the National Board of Medical Examiners Part I and Part II examinations; because of this correlation, the investigators felt the study findings may be generalizable outside the one medical school. It would appear that geriatric content within the medical school curriculum is low; however, the results of the review methods indicate that disagreement exists over the degree of deficiency. The authors conclude that examination review offers an expeditious method to determine the relative emphasis placed upon geriatrics material within specific courses.

Curriculum↗
PubMed1988

Understanding and treating multi-infarct dementia.

MID is a controversial entity responsible for at least 15 to 20 per cent of dementia in the elderly. Clinical manifestations include dementia with abrupt onset, step-wise progression, and focal neurologic signs and symptoms. Infarcts are scattered through the brain involving both subcortical and cortical regions secondary to hypertensive atherosclerotic cerebrovascular disease. Diagnosis is based on the presence of dementia with both cognitive and motor sequelae of stroke as suggested by an elevated "ischemic score." Neuro-imaging studies, while not particularly helpful in differential diagnosis, have identified a population with white matter hypodensity without clinical signs of dementia who may serve as a presymptomatic at-risk group, allowing for studies of the pathogenesis of stroke-related dementia. Management of the cognitive difficulties of MID is similar to that of other forms of dementia. Therapy is directed at patients with modalities that will reduce the likelihood of further vascular insults. This would include treatment of hypertension, cessation of smoking, avoidance of excessive alcohol intake, and use of aspirin for patients with atherothrombotic disease. Medical measures have been shown to be effective in reducing the occurrence of stroke. Further studies are needed to assess the benefits of these measures for MID exclusively.

Aged↗
PubMed1988

Coping with diagnosis related groups. The changing role of the nursing home.

In an attempt to document the changing role of a specific nursing home in the delivery of medical care since the initiation of diagnosis related groups (DRGs), we studied 100 consecutive patients initially admitted to the Veterans Administration Medical Center-Milwaukee Nursing Home Care Unit (NHCU) during the first 23 weeks of 1986 (post-DRGs). Patient characteristics, reason for NHCU admission, and patients' final disposition were determined and compared with those of consecutive patients admitted to the same facility during an identical time period in 1983 (pre-DRGs). More than seven times as many patients were admitted in 1986, and prior to NHCU admission the acute care hospital stay was significantly shorter in 1986 (22 vs 60 days). Whereas in 1983, most patients (94%) were admitted to the NHCU for long-term care placement, in 1986, the majority of patients (64%) were admitted for continuation of therapy started in the acute care hospital. In 1983 only two patients (9%) required hospital readmission within ten days of NHCU admission, compared with 22 (22%) of the patients in 1986. At the termination of the study period, none of the 31 patients admitted to the NHCU in 1983 had been discharged; in comparison, 33% of the patients in 1986 were discharged home. We conclude that in 1986 certain nursing homes drastically changed their role in the delivery of medical care, and are now functioning as extensions of acute care hospitals. Such a role is advantageous in allowing patients to be quickly discharged from the acute care hospital; however, the changing role presents new problems and challenges.

Aged↗
PubMed1986

Prevalence survey of infections and their predisposing factors at a hospital-based nursing home care unit.

A prevalence survey was performed at a Veterans Administration nursing home care unit to detect the frequency, demographics, features, and potential risk factors associated with infections, compare different methods for calculating infection rates, and compare prevalence data with routine physician reporting of infections during a one-month period. In 176 evaluable residents, 22 nursing home-acquired infections were detected, with rates of 12.5% by infections per residents at risk, and 4.6% by infections per 1000 resident-days. Fifty percent of these infections (11 of 22) involved the urinary tract, seven of which were associated with indwelling catheters. Factors potentially associated with increased overall infection rates included immobility (P less than .02), acute-care hospitalization in the 28 days preceding the study (P less than .01) and antibiotics given preceding the infection (P less than .001). An indwelling urinary catheter (P less than .01) potentially was associated with an increased urinary tract infection rate. During the concurrent period, routine physician reporting of infection detected four of the 22 infections (18%) that were identified by the survey. These findings suggest that physician reporting of infection underestimates infection risk as compared with conventional surveillance practices, and that hospital-based care units may have infection problems more similar to acute-care hospitals than to community nursing homes. Identification of potential risk factors is critical in planning preventive practices based on institution-specific needs.

Aged↗
PubMed1985

Age-related differences in knee muscle strength in normal women.

This study provides normal baselines of knee muscle strength for women up to 86 years of age. Knee muscle strength (torque) was measured during maximum isometric and dynamic (isokinetic) contractions in 72 normal healthy women in three age groups between 20 and 86 years. Strength of the oldest group ranged from 56 to 78% of that in the youngest group, depending on knee joint position. Strength values were greater for isometric contractions than for isokinetic contractions (performed at 36 degrees per second) and were approximately twice as great for the extensor as for the flexor muscles. For both muscle groups, the torque generated with the knee in 30 degrees of flexion was usually lower than that generated with the knee at the 45- or 60-degree position. Despite the significant deficit found in the strength of the oldest group, it is likely that this relative weakness would not be detected on routine clinical examination using manual muscle testing.

Adult↗