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Biomedical subjects

E Guthy

Publications and source records attributed to E Guthy.

At least 19 recordsLinked to original sources
PubMed1999

[Clinical signs and diagnosis of acute appendicitis].

Use of the eponyms "Point of McBurney or Lanz" for localisation of abdominal tenderness in appendicits is of little clinical value and confusing to the medical student. "Right lower quadrant" is more appropriate. "Rovsing's sign" and its proposed patho-mechanism are invalid and should be discarded. Differences in axillar and rectal temperatures are non-specific for appendicitis. German surgical textbooks should be revised accordingly.

Acute Disease↗
PubMed1993

[Animal experiment studies of ultrastructural changes in the lamina propria of the ileum caused by dietary fats and comparison with cytopathology in Crohn disease].

Experimental investigations have shown alterations of the ileal mucosal surface after specific fat diets resembling early changes in Crohn's disease. An animal experiment in pigs has been conducted. After creation of an anisoperistaltic segment these were fed either a specific fat diet containing chemically processed, partially hydrogenated fats or a low fat control diet over a period of 3 months. Defined areas of the ileal lamina propria were examined by transmission electron microscopy with the underlying question to what extent ultrastructural alterations could be compared to Crohn's disease. In comparison to the control group these areas were characterized by a dense infiltration of "inflammatory" cells like lymphocytes, histiocytes, macrophages and plasma cells indicating a hyperplasia and activation of lympho-plasmocytotic cells. Additionally, a focal prominent infiltration of mast cells with degranulation was observed as well as a dilatation of axons with depletion of axonal organelles in half of the animals after fat-feeding. Compared to patients with Crohn's disease the results show obvious similarities. It is concluded, that chemically processed fats could cause direct stimulation of immunologically-specific and non-specific cells in the lamina propria mucosae or directly injure the intestinal mucosa with secondary infiltration of inflammatory cells into the lamina propria.

Animals↗
PubMed1992

[Experimental damage of the epithelial layer of the ileum by dietary fats: transmission electron microscopy findings and their comparison with cell pathology in Crohn disease].

Regarding the unknown pathogenesis of Crohn's disease repeatedly the importance of diet has been accentuated. Epidemiological, biochemical and animal experimental results have focused on a possible relationship between the consumption of chemically processed, partial hydrogenated fats and the development of regional enteritis. In this context an experimental animal model in pigs was designed to analyze, whether transmission electron microscopic alterations of ileal mucosa could be induced by forage of chemically processed fats. By creation of a retroperistaltic ileal segment the contact time between chyme and intestinal mucosa was prolonged. Our underlying question was to what extent disorders of the intestinal barrier function could be compared to Crohn's disease. Present study concentrates on the epithelial-cell-layer. It was shown that in comparison to the control animals the lamina epithelialis mucosae of all animals after fat-feeding was characterized by: sublethal lesion of the enterocytes/crypt-epithelial cells (shortening and alteration of the microvilli, degeneration of mitochondria, formation of autophagocytic vacuoles); goblet cell hyperplasia and increased production of mucus; focal appearance of intraepithelial lymphocytes as well as presence of polymorphonuclear granulocytes in the epithelium; widening of the intercellular-space locally up to total loss of the functional structure of the epithelial-cell-layer. In total the picture can be evaluated as an inflammatory process of the ileal mucosa. It can be concluded, that chemically processed fats as used in the described experimental conditions could induce this process. The feature of mucosal damage shows obvious similarities to ultrastructural findings in Crohn's disease if compared.

Animals↗
PubMed1988

[Pathogenesis of Crohn's disease. Evaluation criteria for an animal model].

The origin of Crohn's disease is controverted. Experimental animal studies have not thus far supported a specific pathogenetic factor, a situation ascribed to the fact that the standard requirements of an "ideal" animal model are unsuited to diseases with a multifactorial pathogenesis such as Crohn's disease. In a new experimental animal model the hypothesis of a causal relationship between chemically processed dietary fats and the development of Crohn's disease was studied in 32 pigs. One finding was that experimental animals showed early morphologic lesions of the mucosa as specific to regional enteritis. The primary changes in the mucosa are thought to play a fundamental role in the pathogenesis of the disease. The model opens up new perspectives for planning, management and evaluation of experimental animal models in studying further aspects of etiology in Crohn's disease.

Animals↗
PubMed1984

[Infrared contact coagulation of the liver: technic--tactics--results].

A new generation of infrared contact coagulation devices has been successfully used in 158 hepatic resections and 72 liver transplantations. Hospital mortality was 9.94%; no complications attributable to the method were observed. Infrared contact coagulation is a simple, safe, effective, and cheap method for hemostasis in the liver.

Biopsy↗
PubMed1984

[Tactics and technic of abdominal closure in relaparotomy, abdominal dehiscence and peritonitis].

In cases of reexploration, abdominal wound dehiscence, and peritonitis closure of the abdomen calls for a flexible technique which can be adapted to local circumstances. Skin and the subcutaneous layer should be left open if contaminated from within the abdomen. If multi-layer closure becomes difficult, one should resort to one-layer closure sparing skin and subcutis. If approximation of wound edges becomes difficult or impossible, open stabilization of the abdomen is advocated, a simple method, applicable everywhere with an acceptable risk.

Abdominal Muscles↗
PubMed1984

Comparison of saphir infrared coagulation and YAG-laser in the surgery of parenchymatous organs: an experimental study.

In an experimental study the efficiency of infrared coagulation and the neodymium-yttrium-aluminium and garnet laser (YAG-laser) were compared in operations on the liver, spleen and kidney in the dog. In surgery of the liver, both the YAG-laser and infrared coagulation gave good results. In surgery of the spleen, results with infrared coagulation were excellent, allowing extensive transections and partial resections. Kidney surgery was unsuccessful with either method. Our results are consistent with comparable clinical experience, in that infrared contact coagulation is extremely useful in surgery of the spleen.

Animals↗
PubMed1984

Surgical aspects in the management of peritonitis.

Early diagnosis and early operation of underlying disease are the basis of preventing and treating peritonitis. At operation, besides meticulous technique, minimal contamination and short-term antibiotic prophylaxis diminish the incidence of established infection. Once peritonitis is manifest, massive antibiotic therapy must supplement surgical measures. Open treatment of the septic abdomen can be recommended as a simple and safe procedure with acceptable complications; continuous dorso-ventral lavage in addition may prove beneficial in certain patients.

Aged↗
PubMed1983

[Fat consumption, communal meals and the use of suppositories in patients with Crohn disease].

Contact with chemically modified, especially hardened, fats was found in all of 90 patients with Crohn's disease of the small or large intestine. These fats (margarine, frying or cooking fat) had been encountered before or at commencement of the disease and were used exclusively for cooking in 42 cases, additionally as bread spreads in 46 cases and as bread spread only in 2 cases. Communal meals were taken by 89 patients, in 55 of these at least once per week. 13 patients with anorectal manifestation of Crohn's disease had contact with hardened fats as rectal suppositories prior to or at commencement of the disease. These findings are compatible with the concept that chemically processed fats may play a role in the development of Crohn's disease in susceptible individuals.

Crohn Disease↗
PubMed1981

[Treatment of the injured spleen (author's transl)].

Secure hemostasis in the spleen can be achieved by infrared contact coagulation, a simple, cheap and reliable method. The need for technical splenectomy during abdominal operations can be reduced to one fifth, in blunt abdominal trauma a substantial number of spleens can be saved.

Abdomen↗
PubMed1980

[Phagocyte function in immunosuppressed allograft recipients (author's transl)].

Phagocyte function in immunosuppressed allograft recipients is regularly diminished and correlates to leucopenia in only 50% of cases. Significantly reduced phagocyte function carries a 50% risk of septic complications. Monitoring of phagocyte function can be helpful in assessing defense reserves in the compromised host.

Humans↗