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Biomedical subjects

E Grube

Publications and source records attributed to E Grube.

90 records · Page 5Linked to original sources

[Computer tomographic diagnosis of pericardial effusions (author's transl)].

Thirty patients with suspected pericardial effusions, or with cardiac enlargement of unknown cause were examined by computer tomography. In 19 cases a diagnosis of pericardial effusion or haematoma was made. All these cases were confirmed by echo cardiography or transthoracic puncture. The accuracy of computer tomography diagnosis did not depend on the aetiology, but could be increased by contrast enhancement. The computer tomographic criteria are enumerated and compared with those of echo cardiography. Examples of the most important differential diagnoses are discussed.

Adult↗

[Fast computer tomography for investigation of the heart--"computer cardiotomography". Methods and early results (author's transl)].

The early results in the investigation of normal and pathological hearts using fast computer tomography are presented. By means of tomographic sections of cadaver hearts, it has been shown that it is possible to distinguish the ventricular cavities and individual cardiac walls by this non-invasive method. Changes in volume of the ventricles and atria due to various forms of stress are easily distinguishable. Myocardial scars can be distinguished from other circumscribed myocardial defects. The particular advantages of this method, which is non-invasive, painless and easily repeatable, do not need to be stressed. The technique adds a significant dimension to previously available non-invasive diagnostic methods, such as ultrasound echo-cardiography.

Aortic Valve↗

[Determination of the severity of mitral stenosis by hemodynamic and echocardiographic parameters].

M-Mode and two-dimensional echocardiographic examinations were performed in 70 patients with pure or prevailing mitral stenosis. Mitral valve excursion, mitral valve opening area (MVOAe) and diastolic E-F slope were determined and compared with the gradient across the valve and the opening area obtained during cardiac catheterization. Mitral valve excursion and E-F slope showed mean values of 1.71 cm and 1.98 cm/sec. respectively and were indicative of a stenosed mitral valve. Correlation between E-F slope and gradient with MVOAe was poor. The correlation coefficient was r = +0.56 and r = 0.34 resp. MVOAe compared favorably to the mitral valve area determined at cardiac catheterization (r = + 0.96) and the gradient across the mitral valve (r = 0.90)9 We conclude: 1. Determination of the mitral valve opening area by means of two-dimensional echocardiography represents a valuable addition in the assessment of the severity of mitral stenosis. 2. M Mode echocardiography indicates the presence, but not the severity of mitral stenosis. 3. Computerized planimetry is superior to the manually planimetered opening area and represents a reproducible, exact and time-saving procedure.

Adult↗

[Paroxysmal tachycardic atrial fibrillation: termination by surgically induced A-V block (author's transl)].

In a 58-year-old patient frequent attacks of tachycardic atrial fibrillation had given rise to signs of abnormal cardiac function. All drug treatment had failed, as had several attempts at electric countershock and rapid atrial and ventricular stimulation. For this reason a surgical A-V block at the level of the His bundle was induced under cardio-pulmonary bypass and a ventricular pacemaker inserted. One year postoperatively the pacemaker functions without complication, and the patient is without symptoms. The ECG shows no sign of spontaneous A-V conduction. This is thought to be the first report of surgically induced A-V block for the control of atrial fibrillation.

Atrial Fibrillation↗

[Clinical and haemodynamic results with intra-aortic counterpulsation (author's transl)].

The AVCO balloon pump (model 7) was used on 13 patients with cardiogenic shock and for circulatory support after open-heart surgery. Twelve patients survived, but one patient died of a cerebral embolism which had occurred before the use of the balloon pump. Mean systemic arterial pressure, mean pulmonary artery pressure, pulmonary wedge pressure and heart rate were measured in all patients, while cardiac index and arterio-venous oxygen difference were measured in seven. Average duration of counterpulsation was four days. Vasopressor treatment was reduced or discontinued in all patients, urinary output increased markedly and the clinical state improved. Although systolic pressure did not change significantly, MAP increased significantly by 25 mm Hg (P less than 0.005), with a mean diastolic pressure increase to 104 mm Hg. The pulmonary artery pressure, the pulmonary wedge pressure and the mean pulse rate all decreased significantly by 25 mm Hg, 16 mm Hg and 24 beats/min, respectively. A fall in arterio-venous oxygen difference of 2.6 ml/100 ml (P less than 0.025) was associated with a significant increase in cardiac index by 0.62 l/min-m2 (P less than 0.025). It is concluded from these results that intra-aortic balloon counter-pulsation may be an effective means of providing circulatory support in cardiogenic shock and after open-heart surgery.

Arteries↗

[Heart involvement in progressive systemic sclerosis (generalized scleroderma)].

17 patients with progressive systemic sclerosis were examined for cardiac involvement using standard ECG, chest X-ray, 24-h Holter ECG, and echocardiography. The control groups consisted of 7 patients with mixed connective tissue disease, 10 patients with systemic lupus erythematosus, and 10 patients with rheumatoid arthritis. The results disclosed a cardiac involvement of 70% using all 4 methods, which is more than is reported in the literature. The data also show that all 4 methods are necessary to diagnose the cardiac involvement. Conduction and rhythm disorders especially are more frequent than in other collagen vascular diseases. The use of calcium channel blockers is discussed as a new therapeutic possibility.

Electrocardiography↗