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Biomedical subjects

E Grosshans

Publications and source records attributed to E Grosshans.

At least 163 records · Page 9Linked to original sources
PubMed1994

[Efficacy and tolerance of terbinafine (Lamisil) in a series of 50 cases of dermatophyte onychomycoses].

Terbinafine is an antifungal agent of the allylamine class, which is fungicidal when administered per os. Because of its pharmacokinetic properties, terbinafine proved successful in onychomycoses. The purpose of this study was the evaluation of terbinafine efficacy and tolerance in dermatophyte onychomycoses, in a monocenter open study. Fifty patients have been treated with 250 mg terbinafine daily. Feet were involved in 43 cases, hands and feet in 6 cas, and hand alone in 1 case. Trichophyton rubrum has been isolated in 46 malades, and Trichophyton mentagrophytes in 4 patients. The severity of onychomycoses has been evaluated as follows: involvement of the first toenail (44 cases), total involvement of the nail plate (38 cases), ineffective or non tolerated previous antifungal treatments (37 cases), chronic evolution (mean duration 6.5 years), multiple nails involved (average 6). The mean duration of treatment was 22.2 weeks (range 4 to 8 months). Mycological cure rate was 92 p. 100, and complete cure rate was 86 p. 100. The mean time to mycological cure was 22.4 weeks and the mean time to complete cure was 31.5 weeks. Tolerance was good: minor side effects were noted in 3 patients, and 1 developed reversible agueusia; a moderate elevation of ALAT and ASAT occurred in 1 case. Other drugs were simultaneously administered in 15 patients: no side effects due to drug interactions have been observed. Terbinafine proved highly successful and well tolerated even in those onychomycoses which were difficult to treat. High cure rates were obtained with an average of 5 month-treatment.

Adult↗
PubMed1994

[White lentiginosis].

INTRODUCTION: A congenital guttate hypomelanosis is an unusual feature not yet mentioned in the dermatologic literature. CASE REPORT: We observed 1982 in a 28 y. female patient numerous guttate lesions, which were flat and pigmented on the light-exposed areas of her limbs, flat or papulokeratotic and depigmented on her trunk. These lesions disclosed a particular histological aspect characterized by a lentiginous hyperplasia of the epidermis, with elongated club-shaped rete ridges, and an unusual loss of pigmentation without disturbance of the keratinization. Further electronmicroscopical and immunohistochemical data were not available. The patient emphasized the congenital occurrence of these lesions, whose fixity could be assessed during a 4 year-follow up time. COMMENTS: The unusual histological aspect allows the differentiation of these depigmented spots and other known similar conditions: macular leucoderma as sequellae of previous inflammatory diseases, hypomelanotic macules associated with genodermatoses, idiopathic guttate hypomelanoses. CONCLUSION: This seems to be a not yet described entity which we propose to denominate "white lentiginosis".

Adult↗
PubMed1993

Ectopic contact dermatitis from ethyl cyanoacrylate instant adhesives.

Although allergic reactions to cyanoacrylate adhesives are extremely rare, they should not be considered impossible. We report a young hairdresser who developed an occupational allergic contact dermatitis to 2 "instant glues" used to attach false hair. The eczematous eruption involved the fingers and face slightly but mainly the eyelids. Patch test reactions were strongly positive to ethyl cyanoacrylate adhesives.

Adult↗
PubMed1993

Patch test reactions to mite antigens: a GERDA multicentre study. Groupe d'Etudes et de Recherches en Dermato-Allergie.

We performed patch tests with Dermatophagoides pteronyssinus (Dp) antigens from 2 different sources in 355 non-randomly selected patients with atopic dermatitis (AD) and 398 subjects of a control group. The study demonstrated that contact sensitization to mites occurred in an appreciable % of AD cases (20.8%), using commonly available assay products. The differences recorded between the 2 materials tested were related to the concentration of P1 antigen. Non-atopic patients rarely showed positive reactions to Dp (0.75%), when strict criteria for readings were applied and if 2 readings were performed. Patients with positive patch tests did not necessarily show positive immediate skin tests. It would be useful to carry out tests systematically in atopic patients, even if it is not yet known what modern treatment would be best for the patient. Laboratories still do not provide standardized house dust mite preparations--measuring and codifying their biological activity--for use in patch tests. It is to be hoped that the extension of this type of test will lead to the production of better test materials, in syringes with homogeneous dispersion and concentration.

Administration, Inhalation↗
PubMed1993

Chronic arsenicism: criminal poisoning or drug-intoxication? Report of two cases.

We report two cases with chronic arsenicism. The first one is a young 37-year-old woman who presents leucomelanoderma, plantar keratoderma, polyneuropathy of the legs and transversal striae of the nails. After investigations, criminal intoxication with arsenic caused by her own sister was discovered. The second case is a 42-year-old man who had developed plantar keratoderma, arsenical keratoses and two squamous cell epitheliomas 10 years after a 2-year treatment with Fowler's solution for androgenetic alopecia.

Adult↗
PubMed1993

[Squamous syringometaplasia: an original manifestation of pathomimesis].

INTRODUCTION: Epidermoid syringometaplasia consists in rare changes of the eccrine sweat glands, which show keratinization of their ductal part. Many conditions are associated with epidermoid syringometaplasia: chronic ulcers, scars, keratoacanthoma and various drugs or toxic agents, suggesting a toxic effect of drugs or an inflammatory mechanism. OBSERVATION: A 22-year-old woman presented with large painless ulcero-vegetating lesions of the forearm; the X-ray examination showed an major emphysema. She also had multiple scars on her trunk and limbs. The curious features of the lesions and the psychiatric troubles suggested the diagnosis of dermatitis artefacta. Histopathological examination showed a pseudocarcinomatous epidermal hyperplasia; in the deep dermis the eccrine ducts were connected to the epidermal cell masses or seemed to be included into the proliferation. Keratinization was noted within the keratinocytes surrounding the duct lumen. A dense inflammatory cell infiltrate was observed, containing many macrophages with a foamy cytoplasm, probably resulting from the injection of a foreign substance. All lesions healed within a few days using an occlusive dressing. COMMENTS: In this patient, the voluntary injection of an unknown substance probably induced these metaplastic changes of the sweat ducts, which are probably related to a toxic mechanism. Epidermoid syringometaplasia has never been described after cutaneous injections.

Adult↗
PubMed1993

[Microcapillary hemangioma].

A cutaneous microcapillary hemangioma was discovered in a young woman 4 months after a change of oral contraceptives. This recently individualized benign tumor is made of well differentiated capillaries without cellular atypias, located in the reticular dermis. It arises in a few weeks in young subjects, sometimes after contraceptive change or during pregnancy. Sexual hormonal imbalance may explain some cases. The histological appearance of microcapillary hemangioma is remindful of microvenular hemangioma, more recently described, which also arises in a short time in young patients.

Adult↗