[The effects of an organ preparation on swimming performance, body weight and mortality of aging rats with experimental atheromatosis].
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Biomedical subjects
Publications and source records attributed to E Grandjean.
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We assessed the effects on the judgement of air quality, eye blinking rate,and lung functions of air pollution due to cigarette smoke. At the same time, subjective irritations were recorded. The measured effects were brought into relationship with the concentration of some pollutants in the air.
A social survey in 800 dwellings showed - among other results - the relation between the intensity of traffic noise and the annoyance due to this exposure.
The effects of a 3 h exposition to 150 ppm CO on the flicker fusion frequency and the subjective assessment of 20 subjects have been investigated under two different experimental conditions (monotonous and activating). In the monotonous situation the exposition to CO has induced a relative "activation" of the subjective feelings.
Air pollution is composed of a particulate phase and a gaseous phase. The particulate phase, consisting of dust and aerosols, is the vehicle of toxic pollutants, transporting them into the respiratory tract. The irritants (sulphur dioxide, nitrogen oxides, aldehydes, and hydrocarbons) are the most important pollutants as regards health; the mucous membranes of the eyes and the respiratory tract are mostly affected. Other substances penetrate into the organism where they can develop actions harmful to various organs (carbon monoxide), generate cancer (polyaromatic hydrocarbons) or attack enzymatic systems (lead). Epidemiologic studies have revealed that populations exposed to high degrees of air pollution show increased mortality, which is mainly due to illnesses of the respiratory tract. Atmospheric pollution can also cause sensations of unpleasantness due to irritations of the eyes and the respiratory tract, bad odours, and the impairment of visibility and sunlight.
In a nearly airtight climatic chamber of 30 m3 we studied the air pollution due to cigarette smoke as well as resulting irritations and annoyance. When 9 cig/30 m3 have been smoked, acroleine reaches the threshold limit value for industries; when 5 cig/30 m3 have been smoked, the clean air standards for outdoor air are exceeded by acroleine, carbon monoxide, and formaldehyde. The eyes are the most sensitive organ to cigarette smoke, followed by the nose. Annoyance about air quality and the wish to open the door or to leave the room proved to be other susceptible criteria. With 10 cig/30 m3, 9% of the subjects show a "strong" or "very strong" eye irritation, while 78% "wish to leave the room=. The most important of the measured irritants seems to be acroleine.
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800 new flats were investigated. The comparison between the behavior or the judgements of the inhabitants with various physical parameters revealed many insufficient elements in the flats. Some recommendations can be deduced from this study.