Biomedical subjects

E Goncalvesová

Publications and source records attributed to E Goncalvesová.

11 recordsLinked to original sources

PubMed2002

[Electrocardiography after heart transplantation].

In the submitted review the authors describe the position and importance of electrocardiographic examination after transplantation of the heart (HTx). They describe findings recorded in animal experiments, typical ECG characteristics after HTx and their importance as well as the clinical application of this method for diagnosis of electrophysiological abnormalities specially in relation to rejection and reinnervation of the graft. The authors' conclusions are based on a critical analysis of relevant data in the literature as well as their own experimental and clinical experience.

Animals↗

PubMed2000

["Non-cardiac" surgery in patients after heart transplantation].

UNLABELLED: Aim of the study are description and analysis of the frequency, spectrum and results of "non cardiac" surgery after heart transplantation (HTx). PATIENTS: Up to December 1999, 74 patients (9 females) of age 18-65 years (median 49) were followed-up from 1 to 144 months (median 35) after heart transplantation (HTx). RESULTS: In 10 patients 12 symptomatic non cardiac diseases require surgical procedures. Four had cholecystolithiasis, one patient cholecystolithiasis with choledocholithiasis. The rest of them suffered from renal artery occlusion, carcinoma of the cervix uteri, umbilical hernia, ileus, sigmoidal carcinoma and two from benign prostatic hyperplasia. In all patients with cholecystolithiasis laparoscopic cholecystectomy was performed. In the case of concomitant choledocholithiasis endoscopic extraction of stones was carried out. In the other patients nephrectomy, cervix uteri conisation, hernioplasty, adhesiolysis, resection of sigma and transuretral resection of prostatae were carried out. All procedures were performed by standard methods and no major complications were noted. CONCLUSION: Non cardiac diseases requiring surgical management after HTx are common. By steady improvement of survival after HTx increasing incidence of these conditions has to be expected. The management of them is similar of those in "non transplant" patients. However the care should be paid to immunosuppressive state and therapy.

Adolescent↗

PubMed1999

[Pathology of the spleen in ultrasonographic imaging].

Authors provide review on diffuse and focal splenic lesions, traumatic injuries, contribution of ultrasonography in staging of malignant lymphomas and ultrasound-guided percutaneous biopsy. Special attention is given to the question of normal spleen size and diagnosis of splenomegaly. In 230 patients (98 males) aged 18-72 years (median 34.2) witch underwent complex preventive examination, maximal longitudinal diameter (LDmax) of the spleen were measured. Using linear regression analysis relation of spleen size and body high, weigh and body mass index (BMI) was evaluated. Median LDmax was 10.1 cm, range 7.8-13.5 cm. As a reference limit authors accept 95% confidence interval of median: 7.9-12.3 cm. Statistically significant correlation (p < 0.01, r = 0.31) between LDmax and body high was found out. Ultrasonography because of diagnostic efficiency is suggested the method of choice in diagnosing pathologic involvement of the spleen.

Adolescent↗

PubMed1998

[Preparation for heart transplantation in Slovakia 1994-1997].

The authors present the process of introduction heart transplant programme in the years 1994-1997 in Slovakia. A short historical review about heart transplantation is given in the article. Fundamental requirements for heart transplantation realization, activities of Working group "Heart transplantation", methods of follow-up of patients after heart transplantation and selection of candidates for transplantation, are discussed. The authors also deal with surgical and anaesthesiological prerequisites for this programme realization. In conclusion they claim that the requirements for regular programme of heart transplantation are accomplished. (Tab. 2, Fig. 3, Ref. 21.)

Heart Transplantation↗

PubMed1998

[Hyperlipoproteinemia in patients after heart transplantation].

Hyperlipidaemia is one of the most frequent metabolic disorders after heart transplantation (HTx). The significance of hyperlipidaemia is stressed mainly in relation to graft vascular disease (GVD) which is the leading cause of death more than one year after transplantation. Recently the evidence on the role of hyperlipidaemia (HLP) in the pathogenesis of GVD is growing. Total cholesterol (TC), triglycerides (TAG) HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) were analysed cross-sectionally in 35 patients (30 males), aged 20-64 (median 40) years, more than one year after HTx. In 25 patients HTx was performed because of dilated cardiomyopathy (D-KMP), in 10 because of coronary artery disease (CAD). TC more than 5.6 mmol/l was detected in 29 (83%), TAG > 2.3 mmol/l in 15 (43%), LDL-C >3.6 mmol/l in 28 (80%) and HDL-C < 1.4 mmol/l in 25 (75%) of patients. There were no statistically significant differences in evaluated parameters found between the groups of patients operated on because of CAD and D-CMP, with and without glucose tolerance disorder and groups treated with higher (> 5 mg/D) and lower (.5 mg/D) dose of prednisone. Significant linear correlation of body mass index (BMI) and TAG or BMI and HDL/C resp. was confirmed. Pathogenesis of HLP after HTx is complex. Except of obesity, no unambiguous evidence of the role of glucose tolerance disorder or prednisone dose in immunosuppressive treatment were found. (Tab. 2, Fig. 3, Ref. 21.)

Adult↗

PubMed1997

Adrenal incidentalomas--analysis of 23 cases discovered by ultrasound.

Frequent use of abdominal ultrasonography (USG) increases discovery of incidental adrenal tumors. Our experience and concise review of recent opinions on management of adrenal incidentalomas is presented. In four out of 23 patients with adrenal incidentalomas false positivity of USG was found (all on the left side), 4 cases were identified as pseudoadrenal masses. Hormonal activity was proved in 4 out of 15 true adrenal masses (2 pheochromocytomass, 2 aldosteronomas). Five out of 11 hormonally inactive tumors were benign adenomass, 2 myelolipomas, 2 simple cysts, 1 metastasis of bronchogenic carcinoma and 1 tuberculotic involvement. The smallest tumor was aldosteronoma (2 cm in diameter), the largest was myelolipoma (more than 10 cm). Size of benign adenomas ranged between 2.5-4.8 cm. Three main ultrasonic patterns of adrenal tumors were recognized: (1) anechogenic cysts, (2) complex but predominantly hyperechogenic myelolipomas, (3) hypoechogenic all other masses.

Adenoma↗

PubMed1997

[Trends in alcohol consumption in relation to liver diseases in Slovakia 1973-1994].

The World Health Organisation warns before the increase in alcohol consumption and the proportional increase in ethyltoxic diseases which have taken place in past decades. Slovakia is included into the countries with the highest consumption of alcohol in Europe. The authors present a retrospective analysis of alcohol consumption from 1973 to 1994 in Slovakia according to the kinds of alcohol beverages, in a selected district and according to profession and family status. The epidemiologic analysis of the situation of alcohol consumption that is currently present in Slovakia is based on the data from wholesale and retail sale in relation to the prevalence and the mortality due to hepatic cirrhosis. The presented data was investigated by the Slovak Statistical Institute and the Institute of Medical Statistics of the Slovak Republic. Mortality due to hepatic cirrhosis has increased during the past 40 years 10-fold in men, and 4-fold in women. A severely increasing trend in alcohol consumption which had taken place prior to 1990 was succeeded by an abrupt decrease in pure alcohol consumption after 1990 (as much as by 21.2%). This decrease corresponds with the proportional decrease in the prevalence of chronic hepatopathies (by 35%) and with the decrease in mortality due to hepatic cirrhosis (by 20%). This phenomenon may be explained by the proportional increase in prices of alcoholic beverages. According to average yearly consumption of pure alcohol (p.a.) per capita, the consumption of spirits dominates when compared with the consumption of beer and wine. It is desirable to continue in the begun decreasing trend in alcohol consumption which is crucial in the procurement of primary, secondary as well as of tertiary preventions on both individual and population levels. (Tab. 1, Fig. 6, Ref. 19.)

Alcohol Drinking↗

PubMed1997

[Hematologic aspects of heart transplantation].

Heart transplantation is an accepted therapeutic method for end-stage heart failure. The aim of the presented paper is to provide a short review of haematologic problems of heart transplantation. Haemostatic disorders, cytopenias and lymphoproliferative diseases are the most frequent haematologic complications of this highly sophisticated procedure. Perioperative bleeding tendency is due to cardiopulmonary bypass, both qualitative and quantitative platelet disorders and hyperfibrinolysis are the main causes. Incidence of cytopenias (mono- and/or bi- and/or tricytopenia) reaches up to 70%. They are multifactorial as to etiology and coincidence with viral infection, antimicrobial and immunosuppressive therapy. Lymphoproliferative disease affects about 1.2% of patients during the first year after transplantation. Posttransplant lymphoproliferative diseases are highly variable as to manifestation and prognosis-ranging from indolent course to rapid, aggressive growth. Routine cytostatic therapy is generally ineffective. Crucial therapeutic measure is to turn off immunosuppressive therapy. (Tab. 3, Fig. 2, Ref. 41).

Blood Coagulation Disorders↗

PubMed1997

[Fibrillary glomerulopathy].

The authors present an account on contemporary knowledge of the diagnosis and differential diagnosis of fibrillar glomerulopathies. The latter are characterized by extracellular localized microfibrils and microtubules resp. in the glomeruli of the kidneys, their diameter being 8-60 nm. They are divided into amyloid and non-amyloid types. The others are classified according to the immunofluorescent finding into immunoglobulin positive and negative ones. The differential diagnosis is important in particular in immunoglobulin positive ones as they are present in serious diseases such as cryoglobulinaemia, monoclonal gammapathy, systemic lupus erythematosus and immunotactoid glomerulopathy.

Adult↗

PubMed1995

[Hypercirculatory heart failure in a patient with plasmacytic leukemia].

High cardiac output failure/state (HCOF) is regular feature of some illnesses e.g. thiamine deficiency, hyperthyroidism, severe anemia, Paget's disease or arteriovenous fistulae. HCOF in multiple myeloma is reported quite rarely. 31-year-old man was admitted because of fatigue, dyspnea and subfebrilities. Heart rate was 116/min, sinus rythm blood pressure 110/60 mmHg. Chest film showed cardiomegaly with sings of interstitial pulmonary edema, echocardiography mild dilatation of the left ventricle with hyperkinetic wall motion and small pericardial effusion. Hemoglobin was 104 g/l, leukocyte count 13.5 x 10(9)/l with 30% of plasmatic cells. Serum protein electrophoresis demonstrated a monoclonal gammapathy, X ray studies of the skelet multiple osteolytic lesions. Diagnosis of plasmocytic leukemia-form of multiple myeloma was established and chemotherapy (vincristine + adriamycine + dexamethason) was started. Patient cardiac status deteriorated. Cardiac catheterisation demonstrated mean righ atrial pressure of 25 mmHg, mean pulmonary artery pressure of 28 mmHg and pulmonary artery wedge pressure of 24 mmHg. Co was 20.0 l/min (C.I. 11.5 l/min/m2). In continuing of chemotherapy and symptomatic therapy for heart failure patients status gradually improved and complete remission of the myeloma and normalisation of cardiac parameters was achieved. Heart failure in multiple myeloma patients has been attributed to amyloidosis of myocardium, hyperviscosity syndrome, co-existing CAD or anthracycline toxicity. HCOF should be considered in patients with clinical evidence of heart failure and normal left ventricular function.

Adult↗

PubMed1992

[Significance of laboratory examinations in the diagnosis of iron-deficiency anemia in older persons].

In order to assess the effectiveness of selected laboratory examinations in the differential diagnosis of anaemias in elderly patients the authors examined 170 patients aged 65-93 years. Depending on the cause of anaemia, they divided the group into five sub-groups. Analysis revealed that for the diagnosis of iron-deficiency anaemia the mean corpuscular volume and red cell haemoglobin level have a relatively low sensitivity (63 and 65.6%) and specificity (76.7 and 72.4%), serum iron has a very low specificity (37%) and the total iron binding capacity has a low sensitivity (31.3%). Serum ferritin (sF) has at the lower borderline of the reference interval 30 micrograms/l a 48% sensitivity and 100% specificity; when the value is 65 micrograms/l the respective values are 80 and 99%. Using routine parameters, it is not possible differentiate reliably in this group iron deficiency anaemia during chronic inflammations, infectious diseases and malignant diseases. Examination of SF when the lower borderline of the reference is raised improves the effectiveness of laboratory diagnosis in elderly patient.

Aged↗