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Biomedical subjects

E Golan

Publications and source records attributed to E Golan.

24 records · Page 2Linked to original sources

Hereditary complement deficiency in survivors of meningococcal disease: high prevalence of C7/C8 deficiency in Sephardic (Moroccan) Jews.

The prevalence of complement deficiency was studied among 111 survivors of sporadic meningococcal disease located through the medical records of 10 Israeli hospitals. There were 11 patients with CH50 = 0: one with systemic lupus erythematosus and 10 with hereditary terminal complement deficiency (four with homozygous C7 and six with C8 deficiency). There was no hereditary complement deficiency among 39 Ashkenazi subjects as against 18 per cent among 38 Sephardi subjects and 40 per cent among 15 of Moroccan ancestry (p less than 0.05). The age at first presentation of meningococcal disease in complement deficient patients was 14.7 +/- 7.6, years compared with 8.1 +/- 10.9 in the non-deficient patients (p less than 0.025). None of the complement deficient patients had meningitis below the age of 5 years vs. 49 per cent of non-deficient subjects. Recurrent meningitis was observed in 40 vs. 4 per cent (p less than 0.01) and meningitis in siblings in 40 vs. 2 per cent respectively (p less than 0.001). In addition to the 10 propositi, 11 non-propositus siblings were identified with severe complement deficiency (six with homozygous C7 and five with C8 deficiency). Seven of the non-propositi had no history at all of meningitis or any other serious systemic disease, underlining the relatively favourable prognosis of terminal complement deficiency. With increasing familiarity with the clinical features of this hereditary disease, it is possible now to identify on clinical grounds patients with meningococcal disease with a high likelihood of terminal complement deficiency.

Adolescent↗

Pneumococcaemia as a presenting sign in 3 cases of multiple myeloma.

Multiple myeloma was diagnosed in 3 patients following episodes of pneumococcaemia associated with neutropenia and decreased serum concentration of normal immunoglobulins. Severe pneumococcal infection is commonly encountered during the course of multiple myeloma, but has not been stressed as a presenting feature of the disease.

Aged↗

Terrorist bombing experience during 1975-79. Casualties admitted to the Shaare Zedek Medical Center.

During a period of 4 1/2 yr, 24 terrorist explosions occurred in Jerusalem. Of the 511 casualties, 340 were evacuated to the Department of Emergency in our hospital. A total of 272 admissions were graded by the "Injury Severity Score" (1), with a breakdown into light injuries (87%), medium (3%) and severe (10%). The high proportion of light injuries may be explained by the evacuation of all casualties to the nearest hospital without on-site triage. Injuries to the head and neck comprised 19.3%, and to the extremities 39% of all injuries.

Abdominal Injuries↗

Plastic surgery and civilian casualties due to "terrorist" activities.

Between 1975 and 1979, 511 injuries were caused by "terrorist" explosions in Jerusalem; 340 patients were treated at the Shaare Zedek Medical Center. The injuries were studied and analyzed. The Department of Plastic Surgery bore the brunt of the work, receiving over one-third of all admissions. More than half the hospitalization days went to plastic surgery patients. It seems that when there are large numbers of casualties due to explosions, the plastic surgery service should be enlarged immediately to cope with the large proportion of victims who will be referred to it.

Adolescent↗