Search PubMed⌕ Search

Biomedical subjects

E Godaux

Publications and source records attributed to E Godaux.

At least 73 records · Page 4Linked to original sources
PubMed1984

The optokinetic reflex in the cat: modeling and computer simulation.

After a brief comparative review of the dynamic characteristics of the optokinetic reflex ( OKR ) in different species and after a brief description of the main anatomical structures involved in this reflex, a mathematical model of the OKR in the cat is presented. The experimental results obtained by Godaux and Vanderkelen (1984) in the normal and in the totally cerebellectomized cat were used to validate the model and to obtain an estimation of its parameters.

Animals↗
PubMed1984

Vestibulo-ocular reflex, optokinetic response and their interactions in the cerebellectomized cat.

The effects of total ablation of the cerebellum on eye movements were studied in alert adult cats. The normal cat could easily hold a steady eye position after a saccadic movement in the dark. The cerebellectomized animal could not: after a saccade the eye position shifted towards a more central position. Vision reduced this 'post-saccadic drift'. The sinusoidal vestibulo-ocular reflex (v.o.r.) was strongly affected by total cerebellectomy. In darkness the v.o.r. gain remained stable at high frequencies (0.5 and 1 Hz) but decreased markedly at lower frequencies to as low as 0.18 at 0.05 Hz. A phase advance (up to 65 degrees at 0.05 Hz) paralleled this gain depression. Velocity characteristics of optokinetic nystagmus (o.k.n.) and optokinetic after-nystagmus (o.k.a.n.) induced by constant-velocity full-field rotation of 60 deg/s amplitude and 60 s duration were studied. The features of o.k.n. (initial velocity, maximal velocity and time constant) were only mildly affected by cerebellectomy. On cessation of visual stimulation when the animal was plunged into darkness, the velocity of the eyes decreased progressively (o.k.a.n.). The time constant of o.k.a.n. was 12.5 s in the normal cat and 4.2 s in the cerebellectomized cat. Furthermore cerebellectomy abolished the secondary o.k.a.n. Optokinetic response was also tested by a set of sinusoidal (0.05-1 Hz; 3-20 degrees) full-field stimuli. The o.k.n. was not abolished but dramatically decreased, especially at higher frequencies. No response could be detected above 0.15 Hz. Visual suppression of inappropriate vestibulo-ocular reflex was still possible but was mildly impaired after cerebellectomy. Visual suppression could only be detected with stimuli below 0.25 Hz. Visual suppression of caloric nystagmus was studied in the normal cat. A clear dependence of the effectiveness of visual suppression on the velocity of the nystagmus was demonstrated. In the cerebellectomized cat, the visual suppression of caloric nystagmus was lost when tested on nystagmus velocities above 20 deg/s but remained when tested on nystagmus velocities below 20 deg/s. The relationship between cerebellectomy and the loss of visual suppression of caloric nystagmus was found to be at least partially indirect: cerebellectomy increased the velocity of caloric nystagmus, and visual suppression was usually less effective at higher velocities.

Animals↗
PubMed1983

The saccadic system and the vestibulo-ocular reflex in the cat do not share the same integrator.

We have studied the effects of a neuroleptic, xylidino-dihydrothiazin (XDT), on the sinusoidally induced vestibulo-ocular reflex (VOR) and on the saccades. Very low doses of XDT caused a phase advance and a marked gain decrease at lower frequencies. This is the result one would expect if the integrator of the VOR pathway was off. Low doses of XDT did not affect the shape of the saccades (no post-saccadic slip was observed). This negative result is what one would expect if the integrator of the saccadic system was not disturbed by XDT. It was concluded that the vestibular and the saccadic systems do not share the same integrator.

Animals↗
PubMed1983

Adaptive change of the vestibulo-ocular reflex in the cat: the effects of a long-term frequency-selective procedure.

Ocular movements of naive and adapted cats were recorded by classical electronystagmography techniques during: (1) sinusoidal vestibular stimulation, (2) sinusoidal optokinetic stimulation, (3) sinusoidal additive visual-vestibular stimulation, and (4) sinusoidal conflicting visual-vestibular stimulation. Adaptation of the horizontal vestibulo-ocular reflex (VOR) was produced in adult cats by sustained combined sinusoidal rotation of the cat and its surroundings (fixed-field conditions). This procedure was applied for four hours for four consecutive days. On the fifth day the VOR in darkness, the OKR, the VOR in the light and the visual suppression of the VOR were studied. VOR gain decreased from day to day and some relative frequency-specificity emerged. The gain of the visually inhibited VOR also diminished after training. This change was also frequency-specific. OKN gain, tested by a set of sinusoidal rotations, was found to be virtually unchanged. In the naive cat, VOR modified by the visual stimulus (fixed or moving) could be computed by an algebraic summation of the VOR and OKR eye movement compensations. After training, the gain of the VOR in situations where the VOR was interacting with the OKR remained easily predictable by the algebraic summation of the isolated VOR and OKR compensations.

Animals↗
PubMed1983

Vestibuloocular reflex, optokinetic response, and their interactions in the alert cat.

Ocular movements of alert cats were recorded by classical electronystagmography techniques during (a) vestibular stimulation (sinusoidal rotation of the cat in complete darkness), (b) optokinetic stimulation (sinusoidal rotation of the visual surroundings around the stationary cat), (c) additive visual-vestibular stimulation (sinusoidal rotation of the cat inside the stationary lighted surroundings), and (d) conflicting visual-vestibular stimulation (sinusoidal rotation of the cat together with the visual surroundings in phase and at the same speed). The stimulus amplitudes and frequencies ranged from 3 to 20 degrees and from 0.025 to 1 Hz, respectively. When tested in darkness, the vestibuloocular reflex (VOR) gain was about 0.9 at 1 Hz. At lower frequencies, this gain was a bit lower and a phase lead was observed. The VOR system was nearly linear. The optokinetic response (OKR) gain was about 1 at lower frequencies but strongly decreased at higher frequencies. A phase lag paralleled that decrease in gain. Furthermore, the smaller the amplitude of the visual stimulus, the better the effectiveness of OKR stabilization. When working in the light, the VOR was in phase with the stimulus and its gain was nearly 1, whatever the frequency and the amplitude. The VOR inhibition was more effective at lower frequencies. In these conditions the system was markedly amplitude-dependent for both gain and phase.

Animals↗
PubMed1979

Voluntary motor commands in human ballistic movements.

The integrated electromyogram of the first dorsal interosseous muscle in normal humans presents a brief early burst in voluntary ballistic abduction of the index finger. Unexpected decrease in torque load does not change the burst. By contrast, in fast ramp abduction with a time-to-peak of 0.5 second, the electromyographic activity is fairly continuous up to the peak displacement, and it is silenced with a delay of 50 msec by unexpected unloading. Thus fast ramp, but not ballistic, voluntary contractions are under current long loop control from proprioceptive input. In a second set of experiments, the analysis of single motor unit potentials with highly selective electrodes in interosseous muscle indicated that ballistic thresholds are smaller than ramp thresholds under either isotonic or isometric conditions. However, the recruitment rank of the motor units was identical in finger abductions carried out in either ramp or ballistic modes.

Adult↗
PubMed1978

Ballistic contractions in fast or slow human muscles: discharge patterns of single motor units.

1. Single motor units were recorded from the masseter, soleus and first dorsal interosseous muscles of normal adult man. An analysis of discharge patterns was carried out either during slow ramp voluntary contractions, or during self-initiated isolated ballistic voluntary contractions. The isometric myogram was simultaneously recorded.2. Each motor unit was only recruited when the peak force of a brisk contraction exceeded a certain value and a ;ballistic force threshold' (in kg) was estimated for the unit from a large series of brisk contractions of different strengths. For each muscle, the ranking order for recruitment of different motor units recorded from one electrode position was virtually identical in slow ramp versus brisk ballistic contractions of different force (Kendall rank correlation coefficient = 0.91-1.0). There was no evidence for any consistent selective activation of fast twitch motor units in ballistic contractions.3. The ballistic force threshold is considerably reduced with respect to the slow ramp force threshold for the motor units of the soleus muscle. This drop is also marked for the units of the first interosseous and tibialis anterior muscles, whereas it is only small for the units of the masseter muscle. These data have been validated after consideration of the complicating factor related to the possible differential involvement of synergic muscles in ramp or ballistic contractions.4. In the masseter and first interosseous muscles, the time to peak is about 80 msec in small ballistic voluntary contractions and it increases to about 150 msec in strong contractions. This effect appears related to repetitive discharges of single motor units when their force threshold is exceeded. By contrast, in the soleus muscle, the time to peak remains at about 150 msec both in small and in strong ballistic contractions and most soleus motor units fire only one spike in the ballistic burst.5. Brisk ballistic contractions are graded in force by the recruitment of additional motor units according to their usual rank order. The importance of rate gradation through the repetitive firing of motor units varies in the different human muscles investigated, being quite significant in isometric brisk contractions of the masseter and first interosseous muscles but much less so in the soleus muscle in which little repetitive firing of single motor units was observed over the range of ballistic forces studied.

Action Potentials↗
PubMed1978

Mechanism of the vibration paradox: excitatory and inhibitory effects of tendon vibration on single soleus muscle motor units in man.

1. The parameters of presynaptic inhibition of the Ia spindle afferents from soleus muscle by vibration have been investigated. The inhibitory effects increase with the amplitude of vibration, but decrease when the vibration frequency is increased.2. The monosynaptic reflex threshold of twenty-one single soleus motor units activated in the H (Hoffmann) reflex by a single electrical stimulus to the posterior tibial nerve was estimated quantitatively and expressed in relation to the size of the simultaneously recorded H reflex.3. A parametric study of the effects of various Achilles tendon vibrations on the reflex threshold of the single soleus motor units indicated that their order of derecruitment is concordant with their rank order for activation in the phasic reflexes of the soleus. The last recruited motoneurones are the most susceptible to being silenced by steady vibration.4. Muscle vibration progressively recruits single motor units according to the motoneurone size principle through polysynaptic proprioceptive pathways. However the presynaptic inhibition of Ia spindle afferents simultaneously induced by the vibration works in reverse on the same rank order of motoneurones of the soleus spinal pool, thereby limiting the polysynaptic recruitment of units in the tonic vibration reflex while depressing the autogenic phasic proprioceptive reflexes. These mechanisms elucidate the so-called vibration paradox and extend the size principle of Henneman to presynaptic inhibitory effects.

Achilles Tendon↗
PubMed1977

Ballistic contractions in man: characteristic recruitment pattern of single motor units of the tibialis anterior muscle.

1. Single motor units were recorded with highly selective electrodes from intact tibialis anterior muscle in the adult man. A detailed parametric analysis was made of the discharge patterns during voluntary isometric contractions of different peak forces carried out at various rates of force development. 2. During the smooth tracking of a ramp force, the different motor units recorded from a given muscle site were recruited in a consistant order, each unit becoming active when the muscle developed a certain level of force. The threshold of some of the units in such slow ramp contractions exceeded 8 kg. By contrast, in brisk ballistic contractions reaching a peak force of 12 kg in less than 0-15 sec, the same motor units discharged in a transient burst which largely preceded the muscle force production. 3. In slow tracking ramp contractions, the instantaneous frequency of single motor units was initially rather low (5-15/sec) and it increased as the ramp force augmented. By contrast, in (strong) ballistic contractions, the same units discharged at an unusually high instantaneous frequency (60-120/sec) early in the burst and the firing frequency decreased thereafter. Such hitherto unknown pattern appears characteristic of ballistic contractions and it was not found in even fast tracking ramp contractions achieving 12 kg in only 0-4 sec. 4. The potentials of the different motor units activated are rather crowded at intervals of a few msec in the early burst of a strong ballistic contraction and observations on the rank activation of the different motor units do not provide reliable data for the analysis of the recruitment order of units in ballistic contractions. 5. A new method is described for estimating ballistic force threshold of single motor units. When a large series of brisk ballistic contractions with peak forces ranging from 0-05 to 12 kg was carried out any given motor unit only became active when the ballistic peak force exceeded a certain reproducible value. A detailed analysis of the recruitment order based on these ballistic force thresholds showed it to be virtually identical to the recruitment order of the same units in slow tracking ramp contractions (correlation=0-95). 6. Ballistic contractions are graded in force both by the recruitment of additional motor units in stronger contractions, and by an increase in their rate of firing. These gradation mechanisms are discussed.

Action Potentials↗
PubMed1976

Habituation of exteroceptive suppression and of exteroceptive reflexes in man as influenced by voluntary contraction.

Habituation kinetics were found to vary considerably in different polysynaptic pathways of the brain stem in man. The exteroceptive reflex of the digastric muscle habituates markedly, even for stimuli repeated at 1-min intervals. The second component of the blink reflex habituates for intervals below about 8 sec, but this can largely be prevented by steady voluntary contraction of the muscle. On the other hand the exteroceptive suppressions of the masseter muscle only disclose slight habitaution of their late component ES2 and no habituation of the early component ES1. This does not appear to be affected by voluntary activation since the suppressive effects present the same pattern in relaxed masseter muscles tested by proprioceptive reflex activation. Exteroceptive reflexes and exteroceptive suppressions of similar latencies disclose genuine and important differences in their habituation kinetics.

Adult↗