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Biomedical subjects

E Gitsch

Publications and source records attributed to E Gitsch.

At least 37 records · Page 2Linked to original sources
PubMed1988

Radionuclide-guided radical surgery for cervical cancer.

Radio-isotope radical operation has been developed in three steps. The rate of complete lymphadenectomies determined by the complete removal of labelled tissue was increased from 52.2% in the first observation period to 67.2% in second and finally to 75.8% in the third observation period. Although no improvement could be shown in the survival rate in histological Stage II carcinomas, a marked reduction of recurrence mortality in histological Stage I could be observed: from 15.8% in the first observation period to 12.3% in the second and finally to 8.4% in the third observation period.

Female↗
PubMed1988

[Serum proteins in vaginal and abdominal hysterectomy].

Postoperative changes in various acute-phase-proteins (alpha 1-antitrypsin, c-reactive protein), alpha 2-macroglobulin, haptoglobin, transferrin, c3-c4-complement and myoglobin as well as four endocrine parameters (TBG, SHBG, prolactin and cortisol) were studied in forty healthy women divided into two groups. Each group consisted of 20 women who underwent either vaginal or abdominal hysterectomy. Differences between both groups related to both operative methods, seen in determination of 2-acute-phase-proteins, alpha 1-antithrypsin, CRP and the muscle specific myoglobin where established, whereby no statistically significant differences were apparent concerning the other parameters and hormones.

Acute-Phase Proteins↗
PubMed1988

[Serum proteins and hormones in vaginal and abdominal hysterectomy].

Postoperative changes in various acute-phase-proteins (alpha 1-Antitrypsin, c-reactive protein), alpha 2-Macroglobulin, haptoglobin, transferrin. c3-c4-complement and myoglobin as well as endocrine parameters were studied in forty healthy women in two groups. Women with malignant neoplasms were excluded. Each group consisted of 20 women who underwent either a vaginal or abdominal hysterectomy. Differences between both collectives could be seen in determinations of alpha 1-antitrypsin, CRP and myoglobin, where decreases were significantly higher in the laparotomy group than in the vaginal operation group.

Acute-Phase Proteins↗
PubMed1987

[Therapeutic and prognostic results of a prospective multicenter ovarian cancer study of FIGO stages I and II].

Between April 1980 and December 1985 a prospective controlled and randomized multicenter study of 124 assessable patients with stage I and II epithelial ovarian carcinomas was carried out. The aims of this study were first to verify the value of adjuvant irradiation therapy or combined chemo-irradiation therapy, and second to evaluate the importance of different prognostic factors such as age, histology, tumor grading, and tumor stage. Patients with well-differentiated stage IA tumors did not receive any therapy; patients with undifferentiated stage IA tumors were randomized to "no therapy" or irradiation therapy; patients with stage IB, IIA, and IIB tumors were treated by either irradiation or a combined chemo-irradiation therapy consisting of Adriamycin/Cyclophosphamide. In patients with stage IC and IIC ovarian carcinomas a combined irradiation-polychemotherapy was instituted, consisting either of Adriamycin/Cyclophosphamide or of Adriamycin/Cisplatin. Because of the low number of patients and the relatively good prognosis no definite evaluation of the individual therapeutic modalities could be done. An analysis of all patients showed that differentiation between stage I and stage II ovarian carcinomas is the single most important prognostic factor. After a mean observation time of 42 months (8-71 months) for stage I tumors a 91% probability of three-year survival was attained, in comparison with 57% for stage II tumors. It has not been definitely established that there is a need for adjuvant therapy for stage I tumors and this should be confirmed by further studies. Because of the unfavorable prognosis for patients with stage II ovarian cancer, these patients should be given the same polychemotherapy, including Cisplatin, as patients with advanced ovarian carcinomas.

Antigens, Neoplasm↗
PubMed1987

[Incidence of hyperandrogenemia].

Within two years 341 amenorrheic patients treated in our endocrinological outpatient department were listed up retrospectively in WHO-classification groups. In 30 patients a primary amenorrhea and in 311 patients a secondary amenorrhea could be registered. In 28.3% a hypothalamic pituitary disorder must be diagnosed, in 5.1% a hypergonadotropic profile was observed. Uterine amenorrhea was seen in 0.6%, a hyperprolactinemia in 6.1%. The hyperandrogenemia with an incidence of 42.1% is remarkable and should be included in the WHO-classification.

Adult↗
PubMed1987

[Endocrine profile of patients with post-pill amenorrhea].

"Post-pill amenorrhea" is still a much-debated subject in gynecological endocrinology. The authors therefore studied the reproductive history and endocrinological parameters of 145 patients with the presumptive diagnosis of post-pill amenorrhea, seen in their department during the last two years; 166 cases of secondary amenorrhea served as a control group. The incidence of late menarche (20%), previous oligomenorrhea, and elevated androgen serum levels was high in both groups. There were no significant differences between the two collectives. These findings suggest that although oral contraceptives may have an unfavorable influence on the menstrual cycle, there is no causal relationship between such agents and the development of secondary amenorrhea. It seems that in many cases of presumptive post-pill amenorrhea the common condition of juvenile hyperandrogenemic ovarian insufficiency might be the underlying problem.

Adolescent↗
PubMed1987

[Hyperandrogenemia as a cause of amenorrhea].

The so-called postpill amenorrhea remains a much debated subject in gynecological endocrinology. We have therefore scrutinized the reproductive history and endocrinological parameters of 145 patients with the presumptive diagnosis of postpill amenorrhea, seen at our department during the last two years. 166 cases of secondary amenorrhea served as a control group. Both groups showed a high incidence of late menarche (20%), previous oligomenorrhea and elevated androgen serum levels. There were no significant differences between both collectives. These findings suggest that although oral contraceptives may unfavorably influence the menstrual cycle, there is no causal relationship between such agents and the development of secondary amenorrhea. It seems that in many cases of presumptive postpill amenorrhea the common juvenile hyperandrogenemic ovarian insufficiency might be the underlying problem.

Adolescent↗
PubMed1987

Transfer factor for adjuvant immunotherapy in cervical cancer.

In a prospective randomized double-blind study of 60 patients with invasive cervical cancer, 32 were treated with transfer factor (TF) derived from leukocytes of the patients' husbands, and 28 were treated with placebo. Within the first 2 years after radical hysterectomy, five out of 32 TF-treated patients and 11 out of 28 placebo-treated patients developed recurrence of malignancy. Excluding one further patient with intercurrent death this difference is significant (chi 2 = 3.9915; P less than 0.05). Subdividing the collectives, significant differences were found in patients aged below 35 years and in patients with stage I disease. Identical immune profiles were checked in leukocyte donors prior to leukophoresis and were serially checked in patients. Antigen-specific correlations were found between donors' and recipients' reactivities but not between donors' reactivity and recipient's course of the disease.

Clinical Trials as Topic↗
PubMed1987

Radical isotope surgery: an enrichment for the surgical therapy of gynecological malignancies.

Intraoperative lymphscintigraphy during radical isotope surgery was performed in 242 patients suffering from cervical cancer and 170 patients with breast carcinoma. The results show a decreased rate of recurrence mortality in cervical cancer stage I and a decreased rate of recurrencies and metastases in breast carcinoma. In ovarian cancer patients radiommunoscintigraphy was introduced in the diagnostic procedure and is now performed intraoperatively. The results show a high positive prediction value of 93%. In 5 out of 28 patients radioimmunoscintigraphy identified tumor regrowth while all other methods failed.

Antibodies, Monoclonal↗
PubMed1986

Enzyme immunoassay and Scatchard plot estimation of estrogen receptor in gynecological tumors.

Tissue samples of three endometrial carcinomas, seven ovarian carcinomas, and 24 mammary carcinomas were analyzed for estrogen receptor (ER) by enzyme immunoassay (EIA) and a conventional dextran-coated charcoal (DCC) method. In addition, ER and progesterone receptor were assayed by DCC only in 68 ovarian carcinoma specimens. All three endometrial cancer specimens showed elevated ER values by both assays. As with mammary cancers the ER-EIA values tend to be higher than DCC values. It was intriguing to note that negative Scatchard plot data resulted in residual ER levels in the EIA system. Also four ovarian cancer specimens with negative ER values by the DCC assay had detectable levels by ER-EIA, and three of these four had ER-EIA values less than or equal to 10 fmol/mg of protein. Of the ten breast cancers with negative DCC values, seven were less than or equal to 10 fmol/mg of protein by the ER-EIA. Good correlation (r = 0.88) between EIA and Scatchard plot data was calculated from ER data of 24 mammary carcinoma tissue samples. Receptor assays in 68 ovarian cancer patients indicate that ER determinations should become a useful tool in the management of patients bearing this carcinoma. In addition, receptor determinations may improve the possibility of predicting which well differentiated Stage I ovarian carcinomas are likely to recur. Present data combine to suggest that ER-EIA may become a useful diagnostic laboratory tool.

Breast Neoplasms↗