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Biomedical subjects

E Gilon

Publications and source records attributed to E Gilon.

17 recordsLinked to original sources

Ethnic differences in the prevalence of hepatitis B surface antigen among Israeli blood donors: changes between 1972 and 1988.

The prevalence of hepatitis B surface antigen (HBsAg) carriers among blood donors in Israel during 1988 was compared with that in a similar survey carried out on donors during 1972. The overall age- and sex-standardized prevalence of HBsAg declined from 1.22% to 1.01%. The ethnic differences previously observed were much diminished in native Israelis. The age of highest prevalence shifted from 18-21 to 31-40 years of age, probably due to a cohort effect. The higher prevalence among males has persisted. These findings indicate that the strong ethnic differences in the prevalence of HBsAg previously observed in Israel probably reflect the high rate of infections in the country of birth, and although intra-family spread may have persisted, the overall infection rate in Israel is much lower.

Adolescent

Perforating folliculitis in association with primary sclerosing cholangitis.

Two patients with primary sclerosing cholangitis developed perforating lesions in the skin of the extremities. Clinically and histologically, the cutaneous condition showed the features of perforating folliculitis with superimposed lesions of prurigo nodularis. The course of the eruption paralleled the severity of the biliary disease. A theory of pathogenesis for the development of the perforating folliculitis in these patients is suggested. To the best of our knowledge, this is the first report of the coexistence of both conditions.

Adult

Sclerotherapy for the treatment of fissure in ano.

Sclerotherapy has a useful part in the conservative management of anal fissure. When compared with results obtained with routine forms of local treatment, it leads to a higher incidence of successful outcome and reduced number of patients coming to operation. The complication rate was almost nonexistent and in no instance led to any permanent effects. It is an outpatient procedure and can be done with a minimum amount of equipment, technical skill and expertise, resulting in immediate relief. It does not lead to accelerated healing; this is of no consequence since the patient is asymptomatic. We recommend this procedure for acute anal fissures which cause moderate to marked symptoms, particularly when other conservative methods have failed.

Acute Disease

[Whipple's disease].

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Anti-Bacterial Agents

Colitis.

The disability caused by proctitis or colitis has been assessed among patients attending a hospital outpatient clinic. Although bowel frequency was a common and troublesome symptom, urgency of defaecation with a tendency to precipitate incontinence was a major factor limiting working life and leisure and social activities. Abdominal or rectal pain and lassitude were the other main symptoms. In every aspect of life studied the disability was as great for patients with proctitis or distal colitis as for those with more extensive inflammation of the colon. As a result of symptoms about a fifth of the patients had a reduced earning capacity and quarter were restricted in their social or leisure activities even when symptoms were at their least bad. The social disability of proctitis or colitis may be underestimated because patients do not mention their fear of incontinence and because their complaint of lassitude does not always correlate with the apparent activity or extent of the disease.

Adult

Protracted diarrhea of unknown etiology in Israeli soldiers.

Twenty-five Israeli soldiers, seen over a period of five years, suffered from diarrhea lasting from one month to three years. This was accompanied by weight loss and, in some cases, by evidence of malabsorption and/or mild abnormalities in small bowel and rectal biopsies. The etiology of the diarrhea is unknown, since a routine search for parasites or pathogenic bacteria was unrewarding. An infectious etiology is, however, most likely.

Adolescent

Treatment of ulcerative colitis with azathioprine.

Azathioprine (Imuran) was administered to seven patients with ulcerative colitis suffering from a relapse which could not be controlled by adrenocortical steroids. In four patients remission started one to two weeks after initiation of antimetabolite therapy. Corticosteroid administration was continued concurrently with azathioprine, but the dosage could be reduced and in one case they were withdrawn.Apart from transient leucopenia in two cases, and transient nausea and vomiting in two, no complications were encountered.

Adolescent