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Biomedical subjects

E Götz

Publications and source records attributed to E Götz.

32 records · Page 2Linked to original sources
PubMed1987

A component of factor VIII preparations which can be separated from factor VIII activity down modulates human monocyte functions.

In this study we investigated different aspects of monocyte functions following interaction of monocytes (Mo) with therapeutic concentrations of factor VIII (F VIII) concentrate. A short (one-hour) treatment of normal Mo with F VIII concentrates led to a significant (P less than 0.001) down modulation of Fc receptors expressed in the Mo plasma membrane. This down modulation was accompanied by a decrease of Mo effector functions that was expressed by a reduced capacity of F VIII-treated Mo to release O2 radicals (40% of controls) and to kill bacteria (% killing: control Mo, 65%; F VIII-treated Mo, 24% to 51%). Further studies showed that the modulating activity was due to a contaminant present in F VIII concentrates (immune complexes or IgG aggregates). Fractionation using molecular sieving revealed that the modulatory activity was confined to a high-molecular range fraction (Mr greater than 1,270,000 daltons), while the fraction containing monomeric IgG had no effect. Further fractionation by affinity chromatography on protein A-Sepharose separated the coagulation activity (effluent) from the Mo function-modulating activity (eluate). We conclude that treatment with F VIII concentrates might contribute to an immunocompromised state in some hemophiliacs and facilitate opportunistic infections in these patients.

Antigen-Antibody Complex↗
PubMed1986

[Tolerance of 3.5 percent plasma protein solution].

In a prospective study we found 112 patients out of 9549 who had been given 3.5% plasma protein solution during the preceding year but no other blood derivatives and who had not received any immunosuppressive treatment. 68 patients agreed to be tested for sensitisation to 3.5% plasma protein solution. An intracutaneous test was performed as screening test. Two patients had a false positive reaction, but one of them had urticaria factitia and therefore a positive reaction to NaCl 0.9%. The other patient showed circumscribed reddening in the early phase only, whereas later readings were negative. Neither the test of total IgE by Paper Radio Immuno Sorbent Test (PRIST) nor the test for specific IgE antibodies by Radio Allergo Sorbent Test (RAST) showed any positive results. According to these findings there was no sensitisation to 3.5% plasma protein solution.

Adolescent↗
PubMed1980

Hemodynamic changes in pulmonary circulation following fat embolism.

Hemodynamic effects in pulmonary circulation were measured in three young patients having proved fat embolism following trauma. The increase of pulmonary artery pressure, even in the early phase, was typical. The direction of the therapy to normalise the hemodynamic changes was the most important part of the therapeutic management.

Adolescent↗
PubMed1980

[Anaesthesia in juvenile muscular atrophy (Kugelberg-Welander syndrome) (author's transl)].

A ten-year-old boy with Kugelberg-Welander syndrome was referred to the Ear-Nose- and Throat department for an emergency tracheostomy operation. There was no time for premedication. General anaesthesia was performed with a combination of thiopentone, halothane and nitrous oxide. The patient was awake soon after the operation but developed severe respiratory depression necessitating mechanical ventilation for 12 hours. The causes of the respiratory depression and the anaesthetic problems presented by these cases are discussed.

Anesthesia, General↗
PubMed1980

[Anaesthesia in hypercalcaemic coma (author's transl)].

Hypercalcaemic coma leads to changes in myocardial efficiency and skeletal muscle tone. It is difficult to recommend a favourable anaesthetic agent for such a rare but acute and serious clinical condition. Our experiences are against administration of enflurane. It seems to be that neurolept anaesthesia is the most suitable method for those patients.

Adrenalectomy↗
PubMed1979

[Therapeutic problems after massive blood transfusions].

The term of massive blood transfusion is still today not clearly defined. Through the introduction of microfilters, however, the clinical problems were decisively reduced. Nevertheless, a persistent shock may also today lead to acute respiratory disease. Further difficulties present the buffering, the slow activation of erythrocyte function in stored blood, the sufficient fluid and electrolyte substitution as well as the observation of renal function and coagulation disturbance. The problems of rewarming the patient and warming the stored blood before transfusion are discussed. Special regard must be paid to early and long enough ventilation during and after massive blood transfusion.

Acid-Base Equilibrium↗
PubMed1978

[Stress-induced peptic ulcer; pathogenesis, clinical features, prevention and treatment (author's transl)].

Stress-induced ulcer is a fairly common acute erosive or ulcerative lesion of the stomach and duodenum that occurs in temporal relationship with, and in response to, stressful physical or mental situations in adults and children. Such situations may arise from surgical operations, severe injuries, especially cerebro-cranial trauma, septicaemia, during intensive therapy, in persons with respiratory or renal insufficiency, in cases of carcinoma, in moribund patients; also included, because of the identical symptoms, are ulcers developing during administration of glucocorticoids, salicylates, anti-rheumatic and anti-phlogistic drugs (pre-disposing factors). The stress-induced peptic ulcer manifests itself in haematemesis, melaena, blood in the stools and in perforation. The latter is often unrecognized because of its asymptomatic and frequently un-dramatic course. Two-thirds of the lesions are in the stomach, predominantly in the form of multiple haemorrhagic erosions; on-third of the cases are located in the duodenum, almost exclusively in the form of an acute ulceration; bleeding, due to arrosion, occurs in an high percentage of these cases. Pathogenetic factors are: shock-induced circulatory disturbances of the gastro-intestinal blood supply with necrosis of the apical mucosal cells, increased gastric acidity (increased histamine release, vagal stimulation and increased production of glucocorticoids), changes in the mucosal barrier (e.g. gastro-duodenal reflux). Cases of stress-induced peptic ulcers complicating a severe primary disease (which is often masked by the intestinal symptoms) carry an unfavourable prognosis. With conservative treatment the mortality rate is still 60 percent; with surgical treatment (neither advisable nor possible in every case) it is 40 percent.

Animals↗
PubMed1976

[Electrolyte studies in major abdominal surgery. I. Neuroleptanalgesia and Variations of the infusion scheme (author's transl)].

In two groups of 30 patients each who had undergone abdominal surgery under NLA (mean anaesthesia time 4h) we found a small but significant reduction in the serum potassium level after 45 min of anaesthesia. Throughout anaesthesia we found a significant reduction of potassium content of red cells, serum sodium and base excess. Potassium balance shows that under anaesthesia and operation potassium moves out of the extracellular space and the red cells into other compartments. At the same time about 75 per cent of infused sodium and water is retained with a positive correlation between the quantities of sodium infused and retained. A modification of the infusion regimen by substituting glucose solution with distilled water and Ringer lactate with normal saline and 5 mval/l KCI only results in a change in blood glucose and serum sodium.

Abdomen↗
PubMed1975

[The effect of halothane on the fructose metabolism in the liver].

Glucose production from frutose (2 mmol) and fructolysis was studied in perfused rat liver. In the presence of halothane (0.5, 1.5, and 4.0 vol%) glucose production was inhibited, whereas lactate production was stimulated. Total fructose metabolism was unchanged. Since halogenated hydrocarbon compounds are known to inhibit the mitochondrial respiratory chain, it is concluded that glucose synthesis is inhibited due to decreased supply of energy-rich phosphates from oxidative phosphorylation. On the other hand, this depletion of energy may be partially compensated for by an increased extramitochondrial energy production due to fructolysis.

Energy Metabolism↗