What are the causes and consequences of the chronic inflammatory state in chronic dialysis patients?
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Biomedical subjects
Publications and source records attributed to E G Lowrie.
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Reliable estimation of blood flow to hemodialyzers is essential to the accurate prescription of therapy. Customarily an air bubble is timed as it traverses a racetrack of known volume and blood flow is calculated from the formula Qb (ml/min) = (volume/BT) (60 sec/min). The linearity of this relationship has recently been questioned. Air bubble velocities were statistically fit to measured blood flows over 6 hematocrit values. From the resulting relationship, Qb (ml/min) = 62 (vol/L) (L/BT)0.96, one can generate a table relating velocity to flow for clinical use.
A hemodialysis-ultrafiltration system has been developed and evaluated. It may be used either as a conventional hemodialyzer or as a nondialytic ultrafilter. When used as a dialyzer an ultrafiltration controller is required to fix ultrafiltration rate at the desired level. Rates of low molecular solute removal are compatible with those observed in commercially available artificial kidney systems, higher clearances are obtained for middle molecules, and the rate of ultrafiltration can be controlled within narrowly prescribed limits.
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