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Biomedical subjects

E G Friedrich

Publications and source records attributed to E G Friedrich.

At least 37 records · Page 2Linked to original sources
PubMed1984

Association of Fanconi's anemia and squamous-cell carcinoma of the lower female genital tract with condyloma acuminatum. A report of two cases.

Two young women had Fanconi's anemia and genital human papillomavirus infection associated with multicentric genital neoplasia. One of these women represented the first documented case of death from vaginal squamous carcinoma associated with Fanconi's anemia. In these two women an apparent biologic compression of the natural history of vulvar and vaginal carcinoma was observed. The finding of condyloma acuminatum in both of them prior to the onset of carcinoma suggests a partial causal association. Involvement of the cervix, vagina, vulva and perianal epithelium by the oncogenic process implies that a field effect occurred in those areas.

Adult↗
PubMed1983

Vaginitis.

Explore the source record for details and available documents.

Anti-Bacterial Agents↗
PubMed1983

The vulvar vestibule.

Vulvar pain, burning and dyspareunia are challenging complaints that often defy attempts at specific diagnosis. The vulvar vestibule is being recognized increasingly as a site of these symptoms, but the entities found at this location are not recognized widely. The clinical and histologic features of the minor vestibular glands, mucinous cysts, vestibular adenitis and vestibular papillae are given as they appeared in 28 patients.

Condylomata Acuminata↗
PubMed1982

The redistribution of benign gynecologic surgery.

The program directors of obstetrics-gynecology residencies in the United States were questioned regarding their perceptions of benign gynecologic surgical volume change at their institutions. Most responding departments had experienced a decline volume during the 5 years prior to the study. This volume decrease tended to be more frequent and more pronounced in those programs involving care of a high percentage of indigent patients. Conversely, programs with a predominantly nonindigent patient population tended to experience increases in volume. Many factors are responsible for this redistribution, including a change in gynecology, itself, which has become increasingly occupied with noninvasive ambulatory techniques.

Diagnosis-Related Groups↗
PubMed1981

Tampon effects on vaginal health.

Despite the occurrence of vaginal ulcers, mucosal alterations, and toxic shock syndrome, large numbers of women continue to find vaginal tampons an acceptable and convenient method of menstrual protection. Government agencies and consumer groups are aware of the potential problems associated with tampon use and are actively concerned with surveillance and public education. Tampon manufactures have joined in this effort and continue to seek methods of improving their product and decreasing the risks associated with the use and abuse of vaginal tampons.

Adolescent↗
PubMed1981

An appraisal of routine direct immunofluorescence in vulvar disorders.

Sixty-four biopsies were obtained from patients with a variety of vulvar disorders for direct immunofluorescence study. Twelve of 24 vulvar biopsies from patients with lichen sclerosus demonstrated deposition of fibrin in the upper dermis, while 7 vulvar biopsies showed fibrin deposition at the dermal-epidermal junction. Blood vessel immunofluorescence was observed in several patients but was not a disease-specific finding. Patients with pemphigus and pemphigoid yielded characteristic reactions and served as positive controls. Direct immunofluorescence may be of value in assessing patients with vulvar disorders, and in particular lichen sclerosus.

Complement C3↗
PubMed1981

Multicentric nature of vulvar carcinoma in situ.

A detailed histologic and DNA-microspectrophotometric study is presented of 31 lesions selected from 12 of 65 patients with vulvar carcinoma in situ whom the authors have seen. In 6 patients the lesions were multicentric and in 6 they were confluent. The purpose of the study was to determine whether or not there was a measurable biologic difference between these 2 distinctly different clinical lesions that would justify separating them into different categories. A hypothesis as to the clonal evolution of multicentric and confluent vulvar carcinoma is presented based on the authors' findings.

Carcinoma in Situ↗
PubMed1980

Carcinoma in situ of the vulva: a continuing challenge.

The epidemiologic data, clinical features, associated diseases, and histologic characteristics present in 50 cases of carcinoma in situ of the vulva are analyzed. A comparison of follow-up results obtained with various treatment methods is presented. With primary surgery the recurrence rate is dependent on the presence or absence of tumor at the surgical margins. Deoxyribonucleic acid patterns, determined by microspectrophotometry, were aneuploid in 92% of the cases studied. Five patients (10%) with aneuploid lesions, observed without therapy, experienced spontaneous regression of tumor and replacement of abnormal areas by euploid epithelium.

Adolescent↗
PubMed1980

Tampon-associated vaginal ulcerations.

Colposcopically visible alterations of the vaginal mucosa associated with the use of tampons have been identified. These include mucosal drying, epithelial layering, and microulcerations. The pathophysiology of these transient changes appears to involve fluid transfer with subsequent impairment of intercellular bridges and loss of cell coherence. Tampon products containing superabsorbents are significantly more likely to produce microulcerations than are conventional tampons when worn at times other than during active menstruation. Chronic production of these alterations could lead to clinically obvious lesions of the vagina, and should now be considered in the differential diagnosis of vaginal ulcers.

Adolescent↗
PubMed1979

The vulvar clinic: an eight-year appraisal.

One thousand forty-three patients made 2,750 visits to the Vulvar Clinic at the Milwaukee County Medical Complex from July, 1970, to July, 1978. This experience is analyzed and the various diseases are grouped in order of frequency. The results shed light on those vulvar problems most likely to be encountered in general office practice and point the way toward future areas of research.

Ambulatory Care Facilities↗
PubMed1978

Psychosomatic vulvovaginitis.

Psychosomatic vulvovaginitis is a real clinical entity that should be suspected in any patient whose vaginal complaints do not correlate with the physical findings. Such patients have usually seen multiple physicians, are "allergic" to most vaginal medications, and exhibit signs of emotional lability. In many cases, psychiatric evaluation and therapy can be of great benefit.

Adult↗
PubMed1977

Postoperative staging of vulvar carcinoma: a retrospective study.

The clinical staging of malignant disease is necessary before initiating nonsurgical therapy. Unfortunately, such staging does not help answer critical questions about the course and natural history of the cancerous process. Answers to these questions are crucial to the planning of future therapeutic programs. A postoperative staging system, amenable to computer analysis, that can be retrospectively applied to a large series of invasive squamous cell carcinomas of the vulva is presented. A review of the experience of a large oncologic service at the University of Buenos Aires, which used this new classification system, shows the system's applicability. Such a system could, in time, provide answers to many questions concerning invasive squamous cell carcinoma of the vulva.

Argentina↗
PubMed1977

Vulvar pruritus--a symptom, not a disease.

Because the underlying causes are so varied, vulvar pruritus must be understood as a symptom and not as a disease entity in itself. Successful treatment depends on proper identification of the underlying disorder.

Candidiasis, Vulvovaginal↗