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Biomedical subjects

E G Bywaters

Publications and source records attributed to E G Bywaters.

At least 37 records · Page 2Linked to original sources
PubMed1978

The selection of patients for controlled trials.

The selection of patients for testing drugs is a very complicated process even overtly; subconscious bias must be avoided and our social conscience respected. It is of prime importance to define in advance exactly what you want to test and this may include not only the therapeutic and pharmacological effects and side-effects, the long-term neoplastic potential, the mutagenic effects and the effects on the foetus, but also mundane effects like credibility, acceptance, and even taste! Patient selection is not just "Attention there Volunteers nos. 1,3,5,7,9,....step forward smartly from the left". It is a complicated process in which there is inevitably some bias and our job is to see that any biases which are included do not bias the results, and that the results are understood to apply to this particular selection of patients and not to any other. Too many explicit exclusions therefore make results less useful because less widely relevant.

Clinical Trials as Topic↗
PubMed1978

A family with primary protrusio acetabuli.

The family of a child who developed symptoms and flexion contractures with protrusio acetabuli rapidly between the age of 8 and 11 was examined. The mother and one sib showed limitation of hip movements, while radiological criteria for protrusio were found in the mother and 4 of the proband's 8 sibs; only one had complained of pain. At the age of 16 the proband underwent bilateral total replacement arthroplasty; histologically the changes were those of fibrocartilaginous replacement and osteophyte formation.

Acetabulum↗
PubMed1977

Pathologic aspects of juvenile chronic polyarthritis.

The pathological changes in juvenile chronic polyarthritis are similar to those of adult chronic polyarthritis, although perhaps rather more variable, according to the severity and the phase of the disease. The differences that are seen depend on age, developmental stage, growth, and perhaps a greater regenerative capacity. The nodules of seronegative diseases resemble those of rheumatic fever and are not seen in adult onset seropositive rheumatoid arthritis. In addition, ankylosis of the cervical spine is a characteristic feature seen also in adult onset Still's disease.

Arthritis, Juvenile↗
PubMed1976

Scleroderma in childhood.

Scleroderma in childhood is a rare but confusing disorder. Systemic and diffuse disease do occur but are uncommon. Much more common are local lesions of different types which can be multiple; these are often associated with joint symptoms and the development of joint contractures and tendon contractures due to nodule formation. In such circumstances the condition mimics juvenile chronic polyarthritis (Still's disease). A third, rare variant, sclerodermatous fasciitis, has also been described in one young patient.

Adolescent↗
PubMed1975

Eosinophil-specific and other granulocyte-specific antinuclear antibodies in juvenile chronic polyarthritis and adult rheumatoid arthritis.

Sera from 151 children of whom 112 had juvenile chronic polyarthritis (JCP), and from adults with rheumatoid arthritis (RA), and from healthy pregnant females were tested for the presence of granulocyte-specific antinuclear antibodies (GS-ANA). These were detected in 20% of sera from cases of JCP, in 68% of adult RA, but in none of the controls. Eosinophil-specific ANA were the only ANA present in 18% of positive children and 54% of the positive adults. GS-ANA in children were predominantly IgG and of low titre. Heat-stable GS-ANA were detected in sera from eight children but none bound complement. The presence of GS-ANA was not significantly associated with sex, age of onset, duration of disease, mean active joint count, mean ESR, nor with the presence of fever, rash, splenomegaly, amyloidosis, pericarditis, or rheumatoid factor.

Antibodies, Antinuclear↗