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Biomedical subjects

E Furman

Publications and source records attributed to E Furman.

30 records · Page 2Linked to original sources
PubMed1985

Effect of global vs regional ischaemia upon myocardial contractility and oxygen balance.

The possible role of catecholamines upon the nature of myocardial response to regional and global left ventricular ischaemia was investigated. Global ischaemia was accomplished by temporary occlusion of the left main coronary artery and regional ischaemia by temporary ligation of the left anterior descending coronary artery. Isometric force of contraction was measured with strain gauge arches, regional blood flow by a thermistor technique and intracellular NADH redox level by a fluorometric technique. These measurements were made simultaneously in two areas on the left ventricular myocardium: one immediately below the bifurcation of the LAD and the other immediately below the circumflex coronary artery. Following LAD occlusion a variable inotropic response was observed in the ischaemic area. A decrease in contractile tension was found in 19 of the dogs (44%), no change in 23% and an increase was found in 33%. Global ischaemia invariably resulted in a decrease in contractile tension. NADH redox state was markedly higher during global than during regional ischaemia. Propranolol administration blocked the positive inotropic response to regional ischaemia. It is concluded that endogenous catecholamine release may be responsible for increased contractile force during regional ischaemia. This response is apparently limited by the oxygen availability to the tissue.

Animals↗
PubMed1985

Preservation of myocardial oxygen balance and functional reserve by coronary vasodilators.

Reduced myocardial function at very high heart rates may be due to limited coronary blood supply. The effects of the vasodilators nitroglycerin (10 micrograms kg-1 min-1) and elevated CO2 upon regional function during tachycardia were studied. In open-chest anaesthetized dogs, regional contractile force, epicardial tissue blood flow and local NADH redox level were recorded during graded ventricular pacing. It was found that the vasodilating action of nitroglycerin in the unpaced heart was much lower than produced by CO2 (23.6 +/- 5.8% vs. 137.6 +/- 33.5%). Maximal pacing at 275 bpm caused only a moderate flow elevation in control (20 +/- 6.8%) and CO2 conditions (20.3 +/- 4.03%), but marked vasodilation during nitroglycerin infusion (85.2 +/- 14.6%). Regional function during tachycardia was improved similarly by both vasodilators. NADH levels increased with heart rates under all experimental conditions, but the absolute NADH levels were consistently lower following vasodilator treatments. The lowest NADH levels were observed during nitroglycerin treatment at all heart rates. It is suggested that nitroglycerin augments myocardial functional reserve by preserving oxygen balance more than predicted by its vasodilatory effect alone.

Animals↗
PubMed1984

Intermittent decathexis--a type of parental dysfunction.

This paper describes a type of parental dysfunction--intermittent decathexis--which apparently has not previously been reported although it occurs frequently, to varied extent. The dysfunction is introduced by some of the clinical material that originally brought it to the author's attention, is contrasted with the more usual parental investment in their children. Its relationship to depression and then to aggression is next clarified. Examples of the manifestations of having been intermittently decathected are offered from both child and adult analyses as well as the impediments it provides for a child's progressive emotional development. Finally, the evidence is presented which led the authors to conclude that metapyschologically intermittent decathexis is a primitive defensive manoeuvre.

Aggression↗
PubMed1983

Studies in childhood bereavement.

A group of child psychoanalysts, associated with the Cleveland Center for Research in Child Development and the Hanna Perkins Therapeutic Nursery School and Kindergarten, studied 23 children who had lost a parent through death. These children varied greatly in socio-economic, religious, racial and ethnic background and had suffered bereavement at different points in their development, as early as a few weeks old and as late as 13 years of age. The majority were in individual psychoanalytic treatment, seen 5 times weekly over several years. Some were treated by way of the parent while attending the Hanna Perkins Therapeutic School. The research group compared and discussed the multitude of data with a view to understanding mourning and the effects of bereavement on the personality, with a view to developing techniques in assisting children and families cope with the stress, and with a view to developing some prophylactic measures to minimize pathological resolutions. The results of the research were published in "A Child's Parent Dies" (1). This paper focuses on sharing those findings which might be helpful to the clinician in the assessment of bereaved patients and in assisting them and their families in the crucial period of parental loss or shortly following it.

Adaptation, Psychological↗