[Anal condyloma acuminata with myiasis].
Explore the source record for details and available documents.
Adolescent↗
Biomedical subjects
E Fuenzalida
Publications and source records attributed to E Fuenzalida.
Laboratory investigations on neuroparalytic accidents associated with suckling mouse brain rabies vaccine. III. -- Preservation of vaccine potency after elimination of murine brain myelin by centrifugation.
Myelin, which has been found in nine day-old mouse brain, was eliminated from weanling mouse brain suspensions by centrifugation at 17,000 g for 10 min, as demonstrated by electron microscopy and guinea-pig inoculation tests for encephalitogenic activity. This centrifugation procedure did not affect the potency of seven batches of suckling mouse brain vaccine, when centrifuged and non-centrifuged samples of the same batches were compared by a modified NIH potency test (t = 0.17). The present results with weanling mouse brain preparations suggest that centrifugation at 17,000 g be used in the preparation of rabies suckling mouse brain vaccine instead of the 1,900 g currently employed, which does not eliminate myelin. This new procedure would be expected to reduce the number of postvaccinal reactions which are attributable to the small amount of myelin which remains in vaccines prepared with new-born animal brains following the current procedure.
Animals↗
[Aspects of the vaccine in the brain of the newborn mice].
Explore the source record for details and available documents.
Animals↗
[Suckling mouse brain rabies vaccine supplemented with an adjuvant. Its use in cattle].
This paper describes two experiments carried out in cattle immunized with suckling mouse brain rabies vaccine (SMB) 14, supplemented with 2% Al (OH)3 15 or Freund's modified incomplete adjuvant 2, 26. When determining the vaccinal dose, it was observed that the immune response was independent from the doses used (Table 1), all animals survived the challenge 30 days after vaccination, as compared to a mortality rate of 80% in the controls. To determine the duration of immunity, an amount of 5 ml was chosen as vacinal dose. Two years after immunization, both vaccines protected 96% of the cattle against a viral challenge that killed 63% of the non-vaccinated controls (Table 2). Statistically significant differences were observed between the antibody levels elicited by both vaccines. Antibody levels observed with the oil supplemented vaccine were higher than those produced by the A1 (OH)3 vaccine.
Adjuvants, Immunologic↗