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Biomedical subjects

E From

Publications and source records attributed to E From.

47 records · Page 3Linked to original sources
PubMed1975

Investigations for skin antibodies in malignant neoplasms.

A group of 451 patients with various malignant neoplasms was investigated for the presence of antibodies against the intercellular substance in epidermis and against the basement membrane in the skin, using the immunofluorescence method. None of the patients had bullous disease. Circulating basement membrane antibodies were found in a 63-year-old man with lung cancer. None of the patients had antibodies against the intercellular substance. No in vivo bound intercellular or basement membrane antibodies were found.

Antibodies, Neoplasm↗
PubMedDate not supplied

Treatment of nongonococcal urethritis: comparison of ofloxacin and erythromycin.

Ofloxacin, a new quinolone carboxylic acid derivative, has been reported to be effective and safe in the treatment of nongonococcal urethritis (NGU). In the present investigation 188 male outpatients with NGU were randomized to double-blind treatment with either erythromycin (500 mg twice a day) or ofloxacin (200 mg twice a day) for seven days. Before therapy Chlamydia trachomatis was isolated from 43.6% of the patients. One relapse and one reinfection occurred in the erythromycin-treated group, whereas all patients in the group given ofloxacin were culture-negative at follow-up. Among the C. trachomatis-positive group of patients, the clinical efficacy of ofloxacin was 83.7%, and that of erythromycin, 77.4% at the final follow-up. In the C. trachomatis-negative group, the efficacy of ofloxacin was 93%, and that of erythromycin, 84.3%. The differences are not significant. No serious adverse effects were demonstrated. The results indicate that ofloxacin might be a valuable alternative for the treatment of NGU in men.

Adult↗
PubMedDate not supplied

Microscopy of tonsillar smears and sections in tonsillar gonorrhoea.

Microscopy of methylene-blue and Gram-stained smears from the tonsillar surface and an immunofluorescence (IF) test were carried out for 130 patients, 129 with genital and/or anal gonorrhoea, 27 of whom also had tonsillar gonorrhoea. One patient had only tonsillar gonorrhoea. 5 of the 28 patients with tonsillar gonorrhoea had acute tonsillitis and for these, agreement was found between culture, light microscopy and IF test, while only 5 of the remaining 23 patients had positive microscopy. Among the 102 patients who did not have tonsillar gonorrhoea a few false-positive light microscopies and IF tests were found. Microscopy of haematoxylin-eosin stained sections of 8 tonsils from 4 patients with recurrent tonsillitis and tonsillar gonorrhoea showed subacute tonsillitis. Methylene-blue and Gram-stained sections revealed gram-negative diplococci morphologically similar to gonococci. The bacteria were located in the superficial layers of the mucous membrane (frequently intracellularly in leukocytes) and occasionally in cellular debris in the crypts.

Antibodies, Bacterial↗