Maleic acid as inhibitor of enzyme reactions induced by SH-compounds.
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Biomedical subjects
Publications and source records attributed to E Friedmann.
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This paper describes sudden extreme drops in blood pressure in both experimental and clinical situations when a person is talking about or describing situations of hopelessness and helplessness. These changes are discussed in the context of historical perspectives about the cardiovascular system. A new perspective is introduced, one in which these blood pressure changes are seen as part of an unheard cry for understanding. It is hypothesized that such changes do not occur in response to a person's attempts to communicate a sense of hopelessness, but rather are the biological foundations of the hopelessness itself. Viewed from such a context an entirely new therapeutic approach is outlined regarding the treatment of patients suffering from a wide variety of psychosomatic as well as psychological disturbances.
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Recent technologic advances have permitted the observation of rapid and significant increases in blood pressure (BP) during verbal communication. The magnitude of the increase in BP is influenced by rate of speech, audience size, status, affective content, environmental setting, and resting BP. The current study evaluates the effect of communicating without vocalizing in 38 deaf adults. Similar to speaking individuals, deaf individuals exhibited significant increases in BP and heart rate (HR) while signing, and the magnitude of the increases were related to resting BP levels. These findings suggest that communication, independent of vocalization, has significant effects on the cardiovascular system. Further studies are needed to explore other dimensions of cardiovascular-communication relationships in deaf populations.
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While the physiological mechanisms linking Type A behavior pattern (TABP) to increased coronary heart disease (CHD) risk are unknown, extreme cardiovascular reactivity to daily activities and stressors has been proposed as a mechanism for promoting the progression of atherosclerosis and CHD. Verbalization, either talking or reading aloud, is known to cause significant increases in the blood pressure and heart rates of individuals, including cardiac patients. Blood pressure and heart rate responses of 111 Type A and Type B cardiac patients during verbalization were examined in this study. Blood pressure and heart rate increased significantly during verbalization for all patients. The TABP, measured with both the structured interview and the Jenkins Activity Survey, had little relation to cardiovascular responses.
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The 52 children in the study were recruited from two fifth grade classes in Baltimore city. The blood pressures and heart rates were recorded both at rest and while they read aloud in a classroom setting. A computerized monitoring system was used to measure blood pressures. Rapid and highly significant increases in blood pressure and heart rate were observed when the children read aloud. A total of 84 measurements of 312 systolic and diastolic readings were not within the 95th percentile of normal pressure for the child's age and sex. The data indicate that a routine school task, that is, reading aloud, may have significant effects on the cardiovascular system. These findings are discussed in terms of previously unexamined links between certain childhood school experiences and potential problems with adult hypertension.
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