Biomedical subjects
E Friedman
Publications and source records attributed to E Friedman.
Personality. Good leaders make sure that their organizations, not themselves, are the source of inspiration.
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Watch your language. The terms health care professionals casually toss around are more damaging than they think.
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The butler did it.
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Making choices. Are you experienced?
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Plague. The AIDS epidemic offers a host of lessons in stemming the next scourge.
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Malignant vascular tumor of the hallux.
A rare case of a malignant hemangioma of the great toe is reported. The etiology, incidence, clinical presentation, differential diagnosis, and pathology of an hemangioendothelioma is presented. The basis for surgical treatment and medical management to rule out metastases was discussed. Amputation remains the treatment of choice for hemangioendothelioma.
[Roentgenologic diagnosis of Hirschsprung's disease in the newborn].
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High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer.
Several genes have identified that play a role in colon cancer development. However, less is known about factors that increase the rate of progression of colon cancers to metastasis. One candidate is transforming growth factor beta 1 (TGF beta 1), which can enhance the aggressiveness of human colorectal cell lines in vitro and in vivo. The amount of TGF beta 1, TGF beta 2, and TGF beta 3 protein isoforms expressed in primary site colorectal cancers were measured to determine whether any correlation existed between protein levels and disease recurrence in a series of Memorial Sloan-Kettering Hospital patients who underwent potentially curative resections. Intense staining for TGF beta 1 correlated significantly (P < 0.0013; odds ratio, 18) with disease progression to metastasis and was independent of nodal status and the degree of differentiation of the primary tumor. Therefore, in this study, patients with high TGF beta 1 protein levels in their primary site colorectal cancer were 18 times more likely to experience recurrence of their disease than were patients whose tumors exhibited low levels of TGF beta 1. In this case-control study, patients whose cancer recurred and those remaining cancer free were age and sex matched. The disease recurred at a mean of 26.8 +/- 4.3 (SE) months, whereas the mean follow-up time in patients whose disease did not recur was over twice as long, 57.3 +/- 6.6 months. Ninety-four % of the patients in each group were node positive at the time of resection, with equal mean numbers of positive nodes per patient.(ABSTRACT TRUNCATED AT 250 WORDS)
Optic atrophy, diabetes mellitus, hypothlamic dysfunction and a small sella turcica.
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Could the 185delAG BRCA1 mutation be an ancient Jewish mutation?
A predominant mutation within the BRCA1 predisposition gene, 185delAG, has been detected in about 1% of the Ashkenazi population, considered a high-risk group for breast and ovarian cancers. We examined 639 unrelated healthy Jews of Iraqi extraction, a presumed low-risk group, for the existence of this mutation. Three individuals were identified as 185delAG mutation carriers, and haplotype analysis of the Iraqi mutation carriers revealed that 2 of the Iraqis shared a common haplotype with 6 Ashkenazi mutation carriers, and 1 had a haplotype which differed by a single marker. This study suggests that the BRCA1 185delAG mutation also occurs in populations considered at low-risk for breast and ovarian cancers, and that it might have occurred prior to the dispersion of the Jewish people in the Diaspora, at least at the time of Christ.
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene.
BACKGROUND: Myxoma is a rare bone tumor of the mandible and maxillary sinus whose etiology and underlying molecular mechanisms remain unknown. Mutations that inhibit the GTPase activity of the a subunit of the stimulating G protein (Gsa) have been demonstrated in the myocardium of patients with McCune-Albright syndrome. The histopathological similarities shared by cardiac and jaw myxomas coupled with the paucity of reported candidate genes involved in jaw tumor pathogenesis, prompted us to investigate for the presence of gsp mutations in 23 sporadic jaw myxomas. MATERIALS AND METHODS: We used the polymerase chain reaction (PCR) to amplify the appropriate genomic fragments, followed by denaturing gradient gel electrophoresis (DGGE) analysis. RESULTS: No gsp mutations could be demonstrated in any of tumors analyzed, while the technique has a proven capability to detect these specific mutations. CONCLUSIONS: We conclude that mutations of the Gs alpha gene rarely, if ever, are associated with sporadic jaw myxomas tumorigenesis.