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Biomedical subjects

E Foucar

Publications and source records attributed to E Foucar.

At least 55 records · Page 3Linked to original sources
PubMed1985

Adenosquamous carcinoma of the skin. An aggressive mucin- and gland-forming squamous carcinoma.

Two cases of an aggressive cutaneous carcinoma showed both squamous and adenomatous differentiation. These neoplasms invaded subcutaneous structures with a sclerosing pattern, making surgical resection difficult. Unlike the usual squamous carcinoma, glands and epithelial mucin (sialomucin) were produced. This mucin stained with mucicarmine and was sensitive to sialidase and resistant to hyaluronidase digestion. No mucin with similar histochemical properties was found in a study of 50 consecutive cutaneous squamous carcinomas and 50 consecutive basal cell epitheliomas from our files. Literature reports of histologically similar cutaneous carcinomas together with our experience with these two cases suggest aggressive behavior for this category of neoplasm.

Adenocarcinoma↗
PubMed1985

A histopathologic evaluation of nevocellular nevi in pregnancy.

A detailed histopathologic study was performed on 128 nevi removed from 86 pregnant white patients. None of the patients had clinical evidence of the dysplastic nevus syndrome, and none of the excised nevi were clinically suspicious for melanoma. One third of patients reported some change in nevi during pregnancy. Nevi from an age-matched male control population (50 patients) had a spectrum of histologic features essentially identical to the pregnant patients, while nevi from a female control population (51 patients) showed slightly less atypia according to our criteria. The differences found between the nevi from pregnant and control women suggest that a mild degree of histopathologic atypia or "activation" is associated with pregnancy. However, in the population studied, these changes were never of sufficient degree to result in diagnostic confusion.

Adult↗
PubMed1984

Sinus histiocytosis with massive lymphadenopathy. An analysis of 14 deaths occurring in a patient registry.

Sinus histiocytosis with massive lymphadenopathy (SHML) is generally regarded as a benign disorder in spite of its propensity to form large masses and to disseminate to both nodal and extranodal sites. Although in most patients the extent of SHML does not appear to determine disease outcome, recent reports have documented that infiltrates of SHML can cause death. To gain perspective on the role of SHML in patient deaths in this population, the authors analyzed the 14 known fatalities in an SHML registry comprising 215 patients. The average age at death was 33 years. Autopsy was performed on eight patients. SHML infiltrates were clearly the cause of death in only two patients (previously reported). In another four cases persistent SHML was prominent at death. The other deaths were the result of complications of defined immunologic abnormalities (five), or of unusual infections (three). The authors have not seen an example of cytologic malignant transformation of SHML.

Adolescent↗
PubMed1984

Epitheliotropic lymphoma of the small bowel. Report of a fatal case with cytotoxic/suppressor T-cell immunotype.

The authors report the clinical, pathologic, and immunologic features of a case of jejunal cytotoxic/suppressor T-cell lymphoma associated with intractable malabsorption. Histologically, the tumor exhibited striking involvement of small bowel surface and glandular epithelium, and of epithelium in sites of disease dissemination. This epitheliotropism consisted of both cell clusters resembling Pautrier 's microabscesses and single cells within epithelium. Grossly, the jejunal mucosal fold pattern was completely obliterated by lymphoma which formed miliary nodules and multiple distinct tumor masses. Despite aggressive chemotherapy the patient developed widespread disease, and died 11 months after presentation. At autopsy, in addition to disseminated lymphoma, there was a notable activation of hematopoiesis evidenced by extensive extramedullary hematopoiesis and bone marrow hypercellularity. Many lymph nodes spared by the lymphoma showed a polyclonal proliferation of plasma cells and immunoblasts. In view of recent immunologic evidence that normal cytotoxic/suppressor T-cells selectively home to the gut surface epithelium, striking tumor cell epitheliotropism may be a morphologic marker for visceral lymphomas of cytotoxic/suppressor T-cell origin. This unique case broadens the clinical and morphologic spectrum of T-cell disorders.

Epithelium↗
PubMed1984

Immunologic abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy.

In a computerized case registry, containing 220 cases of sinus histiocytosis with massive lymphadenopathy (SHML), 23 patients were identified with clinical or routine laboratory findings suggestive or diagnostic of immune dysfunction. We divided the abnormalities into hematologic autoantibodies (nine patients), glomerulonephritis (three patients), Wiskott-Aldrich syndrome (two patients), joint disease (nine patients), unusual infections (three patients), and miscellaneous (six patients). Nine of the patients had more than one finding prompting inclusion in this study. In five patients, at least one abnormality preceded the onset of SHML. A major difference between this subgroup of 23 patients and the remaining registry population was the mortality rate. Ten of the 23 patients have died, and in many cases the cause of death could be linked to the immunologic abnormality. This study establishes an association between SHML and clinically significant immune dysfunction and provides further evidence that this frequently multisystemic disease may be one manifestation of disordered immunity.

Adolescent↗
PubMed1983

Anaplastic myeloma with massive extramedullary involvement. Report of two cases.

Two patients developed anaplastic myeloma associated with prominent extramedullary disease one and four years after the initial diagnosis of multiple myeloma. Most tumor cells in the extramedullary sites were primitive-appearing and anaplastic, although plasmacytoid differentiation was evident. One patient had concurrent bone marrow involvement by cytologically similar cells, while the other patient was in bone marrow remission when he developed clinically evident soft tissue infiltration. Immunoperoxidase staining showed similar cytoplasmic immunoglobulin in both the mature-appearing and anaplastic cells in both patients. Electron microscopy in both cases showed a morphologic spectrum between the mature-appearing and anaplastic cells. DNA flow cytometric studies following the onset of extramedullary disease revealed a tumor cell population with a high degree hyperdiploid abnormality and unusually high proliferative activity in both cases, consistent with the morphologic anaplasia. Anaplastic myeloma appears to represent a distinct, aggressive variant of multiple myeloma which may result from a transformation of well differentiated myeloma cells to poorly differentiated immunoblast-like cells.

Abdominal Neoplasms↗
PubMed1983

Uncommon features of giant colonic diverticula.

Two patients with giant colonic diverticula were operated upon within one week. Uncommon features of this rare condition were observed in both patients: 1) the diverticulum was located outside the sigmoid colon, 2) smooth-muscle fibers and ganglion cells were present in the wall of the diverticulum, and 3) free perforation into the peritoneal cavity was the presenting symptom. Barium enema in one patient showed no communication between the diverticulum and the colonic lumen, despite evidence of such communication on histologic examination. Both patients were successfully treated by simple excision of the diverticulum without colonic resection.

Adult↗
PubMed1983

Sclerosing lipogranuloma of the male genitalia containing vitamin E: a comparison with classical "paraffinoma".

Sclerosing lipogranuloma of the male genitalia is a rare but distinctive abnormality of the dermis and subcutaneous tissue generally attributed to paraffin injection. We present the results of lipid analysis of lesional tissue from two patients showing the classical clinicopathologic features of this process. No history of local injections could be obtained from either patient. In one case, the patient had applied a vitamin E preparation to the affected area, and tissue lipid analysis demonstrated large quantities of tocopherol and tocopheryl acetate. Analysis of the second case demonstrated a large quantity of tissue paraffin. While this latter patient had applied a topical petrolatum-containing antibiotic preparation to his genital skin, gas-liquid chromatography demonstrated that the paraffins in this preparation differed markedly from the tissue paraffins. No source for this patient's abnormal tissue lipid could be identified.

Aged↗
PubMed1982

Multiseptate gallbladder.

A case of multiseptate gallbladder and nine previously reported, well documented cases are reviewed. Our patient, like most of those previously reported, had biliary symptoms, which were relieved by cholecystectomy.

Adult↗
PubMed1982

The neurologic manifestations of sinus histiocytosis with massive lymphadenopathy.

Sinus histiocytosis with massive lymphadenopathy is a benign pseudolymphomatous disease with distinctive microscopic features. Painless cervical adenopathy is the most characteristic clinical finding, although other node groups and extranodal sites may be involved. Of 200 patients in a case registry, 8 had neurologic symptoms. The lesions included vertebral canal and intracranial infiltrates and a destructive vertebral body lesion. Two patients had both cord compression and intracranial disease; one of them died after 10 years of disease. Seven patients were alive 1 to 15 years after disease onset.

Adolescent↗
PubMed1981

Colon ulceration in lethal cytomegalovirus infection.

Six renal transplant recipients with severe cytomegalovirus (CMV) infection developed colonic ulceration and lower gastrointestinal bleeding. All patients died between four and 84 days following onset of bleeding. Four patients required colon resection to control blood loss. In the remaining two cases, there was complete autopsy examination with thorough tissue sampling of the colon. In addition to routine light microscopic examination, all cases were studied with an immunoperoxidase technic for identification of CMV. Electron microscopic examination of the colon was performed on two cases. In this select group of patents, CMV plays an active role in damaging colonic mucosa, primarily as a result of CMC vasculitis. Clinical and pathologic features of our cases are compared to published reports of CMV infection of the colon.

Adult↗
PubMed1981

Verruciform xanthoma of the penis.

We describe herein a patient with a verruciform xanthoma of the penis. This histologically distinctive lesion is usually confined to the oral mucosa, although two cases occurring on the vulva have recently been reported. To our knowledge, this lesion has not been previously described in other sites. Biopsy for histopathologic examination is required to aid in the identification of this unusual entity. Verruciform xanthomas have been benign, although a squamous cell carcinoma subsequently developed in one patient whose oral lesions were associated with leukoplakia.

Adult↗
PubMed1981

Fibrofolliculoma: a clinicopathologic study.

A 63-year-old woman with numerous fibrofolliculomas on the face, neck, ears, and trunk is described. These papular lesions developed at approximately 30 years of age. Various family members have clinically identical lesions suggesting an autosomal dominant disorder. The hamartomatous lesions consisted of a proliferation of the pilar fibrous root sheath which surrounded anastomosing bands of epithelium arising from the hair follicle. The clinical and pathologic features of pilar complex tumors are reviewed.

Female↗
PubMed1980

Neuroendocrine (Merkel cell) carcinoma of the skin. A histologic and ultrastructural study of two cases.

The clinical, histologic, and ultrastructural features of two cases of a primary cutaneous neuroendocrine neoplasm probably arising from Merkel cells are presented and compared with previously reported examples. This recently described tumor arises in the dermis of elderly individuals, is often locally aggressive, may metastasize to regional lymph nodes, and eventually may cause death. Microscopically, sheets of primitive cells fill and expand the dermis. Ultrastructural study of our cases revealed morphologic similarities to normal cutaneous Merkel cells, including peripherally situated dense-core neurosecretory-like granules, zonula adherens-type intercellular junctions, prominent Golgi apparatus, and varying numbers of mitochondria and rough endoplasmic reticulum. This unusual tumor is readily confused with cutaneous lymphoma and various undifferentiated primary or metastatic neoplasms by conventional light microscopy. The definitive diagnosis can be made only by electron-microscopic examination.

Aged↗