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Biomedical subjects

E Fonseca

Publications and source records attributed to E Fonseca.

136 records · Page 8Linked to original sources
PubMedDate not supplied

Cutaneous ulceration as a sign of methotrexate toxicity.

Methotrexate (MTX) inhibits DNA synthesis by competition with dihydrofolate reductase. Adverse cutaneous reactions to MTX are usually dose-related and have been mainly reported in patients receiving extremely large doses of chemotherapy. Painful erosion of psoriatic plaques has been often reported as an early sign of MTX toxicity, but cutaneous ulceration as a sign of MTX toxicity in patients without psoriasis has only been described in one case. We report a patient with rheumatoid arthritis and without psoriasis who developed cutaneous ulceration on the knuckles as a sign of MTX toxicity. Cutaneous ulceration by MTX toxicity is an exclusion diagnosis and its pathogenic mechanism may be multifactorial, including direct toxicity of the drug in addition to local factors.

Adult↗
PubMedDate not supplied

Necrobiotic xanthogranuloma associated with lymphoplasmacytic lymphoma. Palliative treatment with carbon dioxide laser.

Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a rare non-x histiocytosis with conspicuous lesions mainly located on the periorbital skin. A 68-year-old woman, with a previous history of lymphoplasmacytic lymphoma associated with IgG monoclonal gammopathy over a period of almost 4 years, presented typical lesions of NXG on the periorbital regions and left buttock. Treatment with dioxide carbon laser resulted in great improvement of cutaneous lesions, and no evidence of relapse after a 12-month follow-up. The association of NXG with lymphoplasmacytic lymphoma has not been previously described to our knowledge. The treatment of these lesions represents a true challenge for the clinician and palliative treatment of cutaneous lesions of NXG with CO(2) laser may constitute an alternative treatment in selected cases.

Aged↗
PubMedDate not supplied

[Induction chemotherapy with cisplatin and 5-FU in locally advanced head and neck cancer. Study of 2 administration schedules].

67 patients were included in two different protocols with cisplatin and 5-fluorouracil as induction chemotherapy. Group A (30 patients), received cisplatin in bolus and 5-FU in continuous infusion for 120 hours, and Group B (37 patients), were treated with cisplatin and 5-FU both in continuous infusion for 96 hours. All patients received surgery and/or radiotherapy after chemotherapy. Overall response in Group A was 73% with 27% Complete Clinic Response (CCR), and in Group B 81% with 40.5% (CCR). Overall survival at 24 months was 58% and 63%, respectively.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Dual mycotic infection in a chicken.

A double mycotic infection, caused by Aspergillus fumigatus and a zygomycete-like organism, was histopathologically demonstrated in the lungs of a 12-week-old chicken. A. fumigatus was isolated, but the zygomycete was not.

Animals↗
PubMedDate not supplied

Favus in a fighting cock caused by Microsporum gallinae.

The first diagnosis of favus in chickens in Costa Rica was made in a 1-year-old fighting cock that had lesions surrounding the comb. The etiologic agent was isolated and identified as Microsporum gallinae. The rooster recovered during topical treatment with tolnaftate and oral treatment with griseofulvin.

Animals↗
PubMedDate not supplied

Scleromyxedema associated with arthritis and myopathy: a case report.

Herein we report a patient with scleromyxedema associated with seronegative polyarthritis and proximal myopathy. The histopathologic and electron microscopic features are described and compared with previously reported patients with documented scleromyxedema and myopathy.

Arthritis↗
PubMedDate not supplied

Hypergastrinemia of newborns and infants during breast-feeding.

OBJECTIVE: We determined gastrin concentrations in newborns and their mothers both before and during lactation. METHODS: Twenty-five women who had uncomplicated pregnancies with normal vaginal delivery of healthy infants at term participated in the study. Twelve preterm neonates with low birth weight (LBW) were also studied. Gastrin levels were determined by radioimmunoassay in amniotic fluid and in serum of both the neonates and their mothers at birth and during breast-feeding. Serum levels of gastrin and prolactin (PRL) were measured in the mothers before and after tactile self-stimulation of the breast. RESULTS: In normal newborns, gastrin levels in cord sera were significantly higher than levels in maternal blood and amniotic fluid at birth. However, gastrin cord sera in LBW newborns was lower than in the normal neonates. Nursing resulted in an increment of serum gastrin levels in the infants and mothers; this rise was similar in the 3 postpartum weeks tested. Tactile stimulus of the mother's nipple resulted in increases of both gastrin and PRL. CONCLUSIONS: Newborns at term show significantly higher gastrin levels than do LBW neonates, which may indicate differences in development of the gastrointestinal system. Breast-feeding induced gastrin secretion in both mothers and infants, confirming the presence of an active vagal reflex. In addition, tactile stimulation of the nipple increased gastrin and PRL levels in the mothers. Our data suggest that LBW neonates have deficient production of gastrin, which in turn may indicate an undeveloped gastrointestinal system. An early enteral feeding triggers the postnatal increase in concentrations of gut hormones.

Adult↗