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Biomedical subjects

E Florek

Publications and source records attributed to E Florek.

9 recordsLinked to original sources
PubMed1995

The entrance of surface active material to pulmonary capillaries in the lungs of newborn rats.

In newborn rats we investigated the entrance of surfactant to the pulmonary capillaries a few minutes after the birth. Time is crucial for the process which can be called "drying" of the lung, when a large amount of intraalveolar fluid enters the pulmonary circulation. Ultrastructural studies have revealed bulk transport and endocytosis of surfactant via alveolar septa to the blood vessels, but it is still questionable whether the entrance of surfactant to pulmonary capillaries is related to its clearance or to "drying" of lung's alveoli.

Animals↗
PubMed1992

[The effect of selected xenobiotics and low protein diet on reproduction and offspring of rats. Part I. The course and condition of rat exposure to tobacco smoke].

The effect of tobacco smoke and low-protein diet on rat reproducibility and offspring was investigated in six litters of white rats. Smoke concentration was controlled by determining the air carbon oxide content which averaged 1000 mg/m3. During the experiments blood carboxyhemoglobin level was measured; by the end of exposure, each generation displayed closely similar concentrations amounting to 23.9-26.6%. There were no diet-related differences in blood carboxyhemoglobin concentrations.

Animals↗
PubMed1989

[Carcinoma metastasis into the vermiform appendix].

Metastases into the appendix vermiformis are very rare. The authors present a case of a secondary of gastric carcinoma into the appendix vermiformis. In the patient the malignant disease was manifested with the clinical picture of diffuse peritonitis caused by perforation of the aboral portion of the appendix vermiformis at the site of the exulcerated secondary of the carcinoma. The authors give also an account of secondaries into the appendix vermiformis described in the literature.

Adenocarcinoma↗
PubMed1983

[Toxicodynamic properties of liquids used for cooling high-power turbines. I. Acute, subacute and chronic toxicity].

Oils IWiOL-3 and OMTI are used to cool the high-power turbines. Their toxicodynamic properties are little known, therefore the studies described herein have been undertaken. The studies did not reveal high acute toxicity, as A-DL50 was found to exceed 15 g/kg of body weight. The simultaneous measurements of cholinesterase activity demonstrated its clear decrease, The studies of subacute toxicity after Lim showed that OMTI after a year's exploitation is the most toxic fluid, as C-LD50 for this compound is 6,21 g/kg of body weight, whereas C-LD50 for the other oils is: 22.449 g/kg of body weight for IW i 02-3-n and 20.93 g/kg of body weight for IWiOL-3-e. Studies of chronic toxicity showed decreased cholinesterase activity and no significant changes in the measurements of certain biochemical and haematological. indices.

Acute Disease↗
PubMed1983

[Toxicodynamic properties of liquids used for cooling high power plants. II. Toxicity determined by inhalation and dermal routes].

In experiments on toxicity, IWiOL-3-n aerosol as well as vapours and gases obtained by heating the oil up to 500 degrees C were administered by inhalation to experimental animals. No deaths of animals were recorded however, a significant decrease of cholinesterase activity was noted. The experiments were carried out in the specially constructed experimental chambers and the method of determination IWiOL-3-n in the air was developed. After intratracheal insufflation of IWiOL-3-n, rapid decrease of cholinesterase activity in blood serum was also observed. Tests on dermal toxicity showed very good absorption of the oils through the untouched skin.

Aerosols↗