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Biomedical subjects

E Flatau

Publications and source records attributed to E Flatau.

At least 55 records · Page 3Linked to original sources
PubMed1987

Musculoskeletal symptoms as a presenting sign of long-standing hypothyroidism.

Muscle and joint pains and/or weakness are not usually stressed as central symptoms in hypothyroidism. Two cases of long-standing hypothyroidism presenting with prominent myopathic symptoms are described. The first patient presented with a 12-year history of proximal myopathy, arthropathy and skin abnormalities, and florid primary myxedema was diagnosed. No evidence for a systemic autoimmune process was found. The second patient had been treated with irradiation to the neck 23 years before admission and presented with clinical and laboratory signs of both proximal myopathy and hypothyroidism. Thyroid hormone replacement resulted in a complete recovery of all the musculoskeletal symptoms, with reversion to normal of the very high muscle enzyme levels in both patients. The cases presented illustrate that hypothyroidism can lead to the development of a variety of muscular, rheumatic and dermatologic syndromes easily confused with dermatomyositis or other collagen diseases.

Adult↗
PubMed1985

Extraosseous accumulation of 99mTc-MDP in a benign intrapulmonary calcified focus.

A patient with a benign calcified pulmonary focus concentrating 99mTc-methylenediphosphonate is described. To the best of our knowledge, this is the first description of the accumulation of 99mTc-phosphate compounds in a benign calcified focus of the lung. The value of a routine correlation with X-ray study in every case of focal chest concentration of 99mTc-MDP is emphasized.

Bone and Bones↗
PubMed1985

Idiopathic hypertrophic sub-aortic stenosis (IHSS): a new diagnostic method using ECG-gated thallium-201 myocardial scintigraphy.

A new diagnostic method for idiopathic hypertrophic sub-aortic stenosis (IHSS), using synchronized ECG gated 201Tl myocardial scintigraphy, is described. Twenty patients previously diagnosed as IHSS were evaluated by sequential three-view ECG gated 201Tl and 45 degrees left anterior oblique multigated (MUGA) cardiac blood pool imaging (Group A). The results were compared with two control groups: 20 patients with no previous history of heart disease (Group B), and 20 patients with coronary ischaemic heart disease (Group C). We suggest the following combination of scintigraphic signs as typical and diagnostic to obstructive IHSS: Elevated left ventricular ejection fraction (mean 83.9% +/- 6.15S.D. versus 72.5% +/- 5.35S.D. and 51.2% +/- 13.65S.D. in Groups B and C respectively); Systolic left ventricular cavity obliteration (71% of obstructive IHSS patients versus 0% in Groups B and C); A ratio of more than 1.3:1 in septal to free wall thickness (100% of patients with IHSS); Perfusion/wall-motion mismatch of septum was demonstrated in all (100%) of patients with IHSS (versus 0% in Group B and 10% in Group C). We suggest this last finding as a new specific diagnostic sign for IHSS, with the ability to differentiate between patients with ischaemic coronary heart disease and IHSS patients; whilst both groups may present chest pains, the first group was characterized by 'matching' of perfusion and motion of the affected myocardial wall while the patients with IHSS had 'mismatching' of these parameters. We suggest gated 201Tl myocardial scintigraphy as an additional sensitive tool for the early diagnosis and evaluation of IHSS patients.

Adolescent↗
PubMed1985

Rheumatic carditis presenting as acute myocardial infarction.

Two weeks following streptococcal tonsillitis two patients developed migratory arthralgia, fever and pericarditic chest pain, followed by an episode of severe coronary retrosternal pressure. The ECG during the latter episodes revealed ST elevation in the inferior wall leads, followed later by the appearance of pathological Q waves in the same leads which persisted for only a few days. Radionuclide scans and echocardiographic studies revealed localized involvement of the inferior left ventricle in both cases and, in addition, involvement of the right ventricle in have been suggested to explain the co-occurrence of viral myopericarditis and myocardial infarction (MI)-like picture during acute rheumatic fever can be explained either by coronary vasculitis resulting in myocardial ischemia, or by direct involvement of the myocardium because of an inflammatory process. Both mechanisms have been suggested to explain the co-occurrence of viral myopericarditis and myocardial necrosis. The transient Q waves were probably produced by stunning of the myocytes during the acute phase of the disease. Increased awareness will probably result in detection of similar cases and may contribute to understanding the pathogenesis of the MI-like picture of acute rheumatic fever.

Acute Disease↗
PubMed1984

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells.

A cell line (T17) was derived from C3H 10T1/2 C18 cells after 17 treatments with increasing concentrations of 5-aza-2'-deoxycytidine. The T17 cell line was very resistant to the cytotoxic effects of 5-aza-2'-deoxycytidine, and the 50% lethal dose for 5-aza-2'-deoxycytidine was ca. 3 microM, which was 30-fold greater than that of the parental C3H 10T1/2 C18 cells. Increased drug resistance was not due to a failure of the T17 cell line to incorporate 5-aza-2'-deoxycytidine into DNA. The cells were also slightly cross-resistant to 5-azacytidine. The percentage of cytosines modified to 5-methylcytosine in T17 cells was 0.7%, a 78% decrease from the level of 3.22% in C3H 10T1/2 C18 cells. The DNA cytosine methylation levels in several clones isolated from the treated lines were on the order of 0.7%, and clones with methylation levels lower than 0.45% were not obtained even after further drug treatments. These highly decreased methylation levels appeared to be unstable, and DNA modification increased as the cells divided in the absence of further drug treatment. The results suggest that it may not be possible to derive mouse cells with vanishingly low levels of 5-methylcytosine and that considerable de novo methylation can occur in cultured lines.

Animals↗