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Biomedical subjects

E Fischer

Publications and source records attributed to E Fischer.

462 records · Page 26Linked to original sources
PubMedDate not supplied

[Enthetic reactions of the hand in progressive scleroderma].

Frequent bone changes in progressive systemic sclerosis are the marginal osteolysis, the arthritic erosions and also the reactions at the numerous entheses of the hand, where the resorptive reactions predominate the osteoproliferative ones. The most frequent resorptions occur at the proximal corners of the tufts. At the margin of the tufts there are also enthesitic reactions, but they do not mark the beginning of an acroosteolysis.

Adult↗
PubMedDate not supplied

The international role of a U.S. medical school in developing health services.

This paper discusses the educational approach taken by the Department of Community Medicine of the Mount Sinai School of Medicine in providing technical assistance in foreign countries. Using a specific project in the Dominican Republic as an example, the paper describes the role and different functions assumed by the department in planning and developing a health care system in the eastern region of that country.

Dominican Republic↗
PubMedDate not supplied

Technical assistance offered to community health programs through a resource model.

A multidisciplinary unit in the Department of Community Medicine, Mount Sinai School of Medicine, consists of a core group of specialists who plan, develop, and evaluate community health care programs. The primary tools used by the staff of the Services Coordination Unit, epidemiology and behavioral and management sciences, result in improved organization and coordination of health services and community resources. The small unit of specialists functions as a resource group, helping community groups address the complex problems of planning, organization, delivery, and financing of health services. By offering technical assistance rather than day-to-day health care services, the unit has established an education and training program in New York's East Harlem, which surrounds the medical school. Over the last 10 years, that approach has enhanced the administrative and financial viability of existing health programs in East Harlem. Since the unit's establishment, it has collaborated with a broad variety of community groups. More than 20 programs have resulted. The income generated by the unit completely covers the expenses and has done so since 1976; "seed money" was used for startup and the first 3 years of operation. The unit is paid for long-term services and for most consultations.

Community Health Services↗
PubMedDate not supplied

[Reactions of the overlapping volo-ulnar margin of the ulnar head in chronic polyarthritis--a hitherto disregarded sign].

The volo-ulnar margin of the ulnar head is mostly superimposed by the base of the ulnar styloid, but often remains visible as a contour. The ulnar head is surrounded by the radio-ulnar synovial compartment. At the wrist this compartment is one of the most often affected synovial compartments in rheumatoid arthritis. Therefore reactions often occur at this margin in rheumatoid arthritis with thinning, reactive sclerosis and erosion. These reactions occur as often as the erosions at the neighbouring ulnar styloid.

Adult↗
PubMedDate not supplied

Port Allegany Asbestos Health Program: a community response to a public health problem.

The Port Allegany Asbestos Health Program (PAAHP) is a unique, community-run program that resulted from the successful cooperative efforts of a labor union, a corporation, community health care providers, and a medical school. PAAHP's goal is to develop a permanent community health organization that will use the most advanced existing knowledge to mitigate the adverse health effects anticipated as a result of the use of amosite asbestos in a Port Allegany, Pa. factory. All 1,188 persons employed by the factory during the years 1964-72 and the 3,000-4,000 persons in household contact with them are eligible for the program. PAAHP's major services are intensive medical surveillance, smoking cessation assistance, health education for participants, and continuing education for area physicians about asbestos-related diseases. One of the program's policies is not to disturb the usual patterns of medical care. If further testing or treatment is needed, patients are referred to their usual personal physicians. PAAHP does not provide ordinary medical care or medical insurance. Across the nation, the number of workers estimated to have been exposed to asbestos is more than 20 million, and their household contacts are estimated to be about three to four times that number. Adverse health effects resulting from asbestos exposure include elevated risk of lung cancer, mesothelioma, gastrointestinal tumors, and asbestosis. The problem requires the development of public health solutions. PAAHP has demonstrated the feasibility of a community-based model as one useful approach.

Asbestos↗
PubMedDate not supplied

[Activation of the alternative pathway of human complement (author's transl)].

The C3 amplification convertase of human complement, C3b, Bb, is assembled on biological surfaces by the interaction of the alternative pathway proteins B, D and P with cell-bound C3b. Convertase formation is modulated by the action of the regulatory proteins H and I. On activating surfaces of the alternative pathway, C3b, Bb is relatively resistant to regulation by H. In contrast, non-activating surfaces exhibit surface characteristics such as high content in membrane-associated sialic acid or heparin-related material which increase the interaction of H with cell-bound C3b. Thus, finely tuned molecular interactions allow the alternative pathway to function as a major recognition and effector system for natural defence.

Amino Acid Oxidoreductases↗
PubMedDate not supplied

[Anti-Jo-1 antibodies: specific autoantibodies for polymyositis with interstitial pulmonary fibrosis. 2 case reports].

Anti-Jo-1 antibodies are rare autoantibodies, which bind and inhibit the activity of histidyl-tRNA-synthetase. They are predominantly found in a genetically and clinically distinct subset of myositis patients, presenting with interstitial alveolitis. We describe the case of a 22-year-old woman with Jo-1-syndrome with typical features of myositis, pulmonary fibrosis, nonerosive symmetric polyarthritis, Gottron's papules at the metacarpophalangeal joints and classic heliotrope discoloration of the periorbital area with edema. The patient did not respond to chloroquine, azathioprine, intravenous immunoglobulins or cyclophosphamide. Remission was finally achieved with oral methotrexate plus corticosteroids. The second case describes a 34-year-old man with myositis, who rapidly developed respiratory insufficiency after suffering from joint pain and stiffness for about 10 weeks. He responded well to cyclophosphamide pulse therapy and high-dose corticosteroids. The second case demonstrates that control of the interstitial alveolitis is most important for long-term outcome. Therefore, immunosuppressive drugs should be used along with corticosteroids as early as possible.

Adrenal Cortex Hormones↗