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Biomedical subjects

E Fischer-Brandies

Publications and source records attributed to E Fischer-Brandies.

At least 19 recordsLinked to original sources
PubMed1995

Bone scintigraphy: an aid in deciding on the extent of bone resection in malignant oral tumors.

PURPOSE: The decision of whether to perform continuity-sparing or resecting surgery of the jaw in cases of malignant oral tumors is often difficult. PATIENTS AND METHODS: To aid in this decision, bone scintigraphy was evaluated retrospectively in 304 patients with a squamous cell carcinoma. RESULTS: One hundred forty-five patients showed no accumulation of the radionuclide, and none of them had infiltration by tumor histologically. CONCLUSION: It was concluded that a bone-sparing resection of tumors close to the jaw may be justified when there is a negative bone scan.

Adenocarcinoma↗
PubMed1995

Prognostic significance of DNA ploidy in oral squamous cell carcinomas. A retrospective flow and image cytometric study with comparison of DNA ploidy in excisional biopsy specimens and resection specimens, primary, tumors, and lymph node metastases.

Deoxyribonucleic acid ploidy was determined in paraffin-embedded tumor tissue from 116 patients with primary oral squamous cell carcinomas (including 5 carcinomas of the lip and 14 of the tongue) by means of flow cytometry. One hundred six cases were suitable for evaluation (91%). Sixty-eight percent of the cases (n = 72) showed a nondiploid nuclear DNA content. Nondiploidy correlated significantly with presence of lymph node metastases (p < 0.02) but not with tumor stage, grading (World Health Organization), or relapse-free and overall survival. Carcinomas of the lip and tongue turned out to be diploid more frequently than other oral squamous cell carcinomas (p = 0.002). In the 21 cases in which a comparison of DNA content of excisional biopsy specimens and subsequent resection specimens was possible a difference in DNA ploidy was found in one case only. The comparison of primary tumors and their lymph node metastases in 30 cases revealed a discrepancy of DNA content in five cases (17%), which was connected with a shift from nondiploidy to diploidy in four out of five cases. Fifty cases studied in parallel by means of image cytometry with Feulgen-stained tissue sections exhibited a concordance of the ploidy status in 87% and a significant correlation of the DNA index values obtained with both methods (p < 0.01). These results demonstrate that DNA ploidy in oral squamous cell carcinomas is distributed rather homogeneously within the tumors and remains rather stable in the lymph node metastases. Despite a significant correlation between nondiploidy and presence of lymph node metastases, ploidy failed to be a statistically significant parameter for prognosis in oral squamous cell carcinomas in our investigation.

Aneuploidy↗
PubMed1991

[The accuracy of soft tissue profile prediction with the "Dentofacial Planner" in skeletal prognathism].

30 pre- and postoperative lateral cephalograms of patients with mandibular prognathism are used to evaluate the soft tissue profile prognosis given by the "dentofacial planner". As a result, the horizontal displacement of SLS (sulcus labrale superius) and Pg' (soft tissue pogion) in patients with a normal vertical dimension and additional LMF (labiomental fold) in persons with a marked overbite are calculated well. The horizontal changes of the other points analyzed as well as all vertical changes are not predicted satisfactorily in the momentary version 4.22 A (febr. 1989), which will be improved by the company.

Adolescent↗
PubMed1991

[Radioactive burden resulting from zirconia implants].

Due to its mechanical properties circonia is an interesting implantation material. However, it may contain a certain amount of radioactive isotopes. The measurement of alpha-emission reveals varying amounts of radiation. As a result, a declaration of radioactivity should be required for circonia implants and only circonia with low emission levels should be used for implantation purposes.

Alpha Particles↗
PubMed1990

[Predictability using the "Dentofacial Planner Version 4.22 A" of soft tissue changes following adult orthodontic treatment].

For the prediction of profile changes following orthodontic treatment the computer program "Dentofacial Planner" (DFP) which bases on cephalometric measurements is available. The object of this study is to analyse the precision of the DFP version 4.22 A (release Feb. 89). The material of the study consists of the lateral cephalograms of 33 patients treated for maxillary incisor protrusion. In order to evaluate the ensuing profile changes certain cephalometric parameters are measured pre- and post-therapeutically. They are compared to the values predicted by the DFP. Statistical analysis yields the following results: 1. Clinically acceptable precision was found for seven of the 20 cephalometric parameters. 2. In two of the six parameters stated to be stationary by the DFP notable changes were found in reality. 3. The most accurate prognosis was made for the upper lip profile; the least precision was found for the lower lip. According to the manufacturer the results of this study will be included in alternations of the DFP program so as to achieve improvements in the criticized areas.

Adult↗
PubMed1989

[Augmentation of severely atrophied jaws with hydroxyapatite from a prosthodontics standpoint].

After 4 years of routine application of hydroxylapatite ridge augmentation 109 patients underwent a posttreatment examination. The quality of the alveolar ridge and the denture as well as the functional status of the craniomandibular system were evaluated in detail. For the maxilla good results were obtained in 80-90%, for the mandible in 70-80%. Further improvements seem more probable by the avoidance of prosthodontic faults and the elimination of functional disturbances than by additional surgical procedures such as vestibuloplasty.

Alveolar Ridge Augmentation↗
PubMed1989

[Application of granulate hydroxylapatite for mandibular augmentation].

The already known surgical interventions for absolute induction of extensive mandibular atrophy, cannot be suggested as routine standardized methods. Use of Hydroxylapatite-ceramic for restoration of the atrophic alveolar process, shows several advantages; among those, simplicity of the operation use of local anesthesia, as well as very low percentage of unsuccessful interventions are taken into consideration. The clinical results of 102 cases are shown and discussed. Through the addition of H.A. ceramic in the field of preprosthetic surgery, there is a broadening of the spectrum of the therapeutic possibilities of patients with prosthetic problems to be expected.

Alveolar Ridge Augmentation↗
PubMed1989

[Maxillofacial injuries in polytrauma. Results of a follow-up study].

Evaluation of the clinical charts of 86 patients with polytrauma, accompanied by fractures of the facial skull, and reexamination of 48 of these patients showed that with adequate therapy the concomitant lacerations do not influence the results of orofacial treatment. The complexity of the anatomical structures and of their functions necessitates early, differentiated, and interdisciplinary treatment. The special aspects and problems are presented and discussed.

Adolescent↗