Biomedical subjects

E Faught

Publications and source records attributed to E Faught.

94 records · Page 6Linked to original sources

PubMedDate not supplied

Electroencephalographic correlations of extracranial and epidural electrodes in temporal lobe epilepsy.

Thirty patients with medically intractable complex partial seizures of temporal lobe origin, but no structural abnormalities on neuroradiologic investigations, had both extracranial (scalp) and epidural EEG recordings. Fifteen patients (50%) had localized, unilateral, ictal, scalp EEGs, but one of these had bilateral independent temporal seizure onset according to epidural recordings. Of the 15 patients in whom scalp EEGs were non-localizing, 12 had well-localized epidural ictal EEGs, and 3 had multifocal or bilateral independent temporal ictal recordings. Epidural recordings provide information for determination of site of onset of temporal lobe seizures in selected patients.

Adult↗

PubMedDate not supplied

Antiepileptic drug treatment after temporal lobe epilepsy surgery: a randomized study comparing carbamazepine and polytherapy.

Temporal lobectomy is an effective treatment in selected patients with medically intractable temporal lobe epilepsy (TLE). Postoperative antiepileptic drug (AED) treatment guidelines have not been established, and patients are often treated with polytherapy postoperatively. We prospectively randomized 40 patients undergoing temporal lobectomy to monotherapy with carbamazepine (CBZ, 20) or to continuation of their presurgical polytherapy (20) to assess the efficacy and safety of each regimen during the first year after operation. No significant differences between groups were noted with respect to seizure recurrence rate and type or time of recurrence. Patients in the polytherapy group had a 30% incidence of drug-related side effects as compared with only 10% in the CBZ group. These results suggest that after temporal lobectomy for intractable epilepsy, patients can be safely treated with CBZ monotherapy and that treatment with multiple AEDs is not necessary.

Adolescent↗

PubMedDate not supplied

Physical exercise, stressful life experience, and depression in adults with epilepsy.

Adults with epilepsy completed self-report measures of exercise participation, barriers to exercise, stressful life experience, depression, and general psychosocial adjustment (n = 133) as part of routine outpatient visits. Descriptive statistics showed lower levels of depression among patients who exercised regularly. Structural equation analyses confirmed the fit of a path model that included significant direct effects of exercise and stressful life experience on depression. These effects were independent of each other, and independent of the influence of other predictor variables, such as seizure frequency, age, and gender. Stressful life experience also had a direct unique effect on seizure frequency in the multivariate models. These results suggest that problems with depression, which are common in adults with epilepsy, are significantly lower among those who exercise regularly and avoid stressful life change.

Adolescent↗

PubMedDate not supplied

Brainstem auditory evoked responses in brainstem infarction.

Brainstem auditory evoked responses (BAERs) were recorded in 40 patients with clinically definite brainstem infarction, and results were compared to localizations from physical signs and CT scans. The BAER was abnormal in 92% of patients with evidence on physical examination of dysfunction of lateral structures in the pons or midbrain. Normal BAERs were seen with medially-situated or medullary lesions. When both rostrocaudal level and lateralization were considered, the BAER indicated damage in additional areas not evident on physical examination in 25% of patients. However, physical signs indicated damage in areas not reflected by the BAER in 22% of patients. Therefore, the BAER complements the localization obtained from physical findings. BAERs were abnormal in more of these patients than were CT scans, and thus are useful for confirmation of bedside impressions.

Brain Stem↗