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Biomedical subjects

E Fagelman

Publications and source records attributed to E Fagelman.

7 recordsLinked to original sources
PubMed2001

Efficacy, safety, and use of sildenafil in urologic practice.

OBJECTIVES: To evaluate the efficacy, side effects, renewal patterns, and other relevant practice issues of the use of sildenafil in urologic practice after approval of this medication and release for public use. METHODS: Consecutive male patients with erectile dysfunction were evaluated by one urologist and sildenafil was prescribed when appropriate. Patients were monitored at two follow-up visits: at 3 to 4 months and then at 3 to 8 months (6 to 12 months after the initial prescription). At the follow-up visits, each patient was given a questionnaire assessing his improvement in erectile function, satisfaction with sildenafil, and expectations. Data were obtained on side effects, medical history, tablets taken, subsequent treatment in sildenafil failures, and renewal patterns. RESULTS: A total of 164 and 82 patients were evaluated at the first and second follow-up visits, respectively. Patients used a mean of 1.2 to 1.4 tablets per week. At the first follow-up visit, an improvement in erection was noted in 68.2% of patients. At the second follow-up visit, an improvement in erection was noted in 80.5% of patients. Sixty-two percent and 78% of patients renewed sildenafil at the first and second follow-up visits, respectively. In those patients who did not renew, a lack of efficacy was the most frequent reason. Intracavernous injection therapy was the most common treatment after sildenafil failure, followed by penile implants. CONCLUSIONS: Sildenafil is an effective and safe drug in the treatment of erectile dysfunction. At the first and second follow-up visit, most patients requested and received renewal.

Adult↗
PubMed2001

Saw Palmetto Berry as a Treatment for BPH.

Phytotherapeutic agents are often prescribed in Europe for the treatment of benign prostatic hyperplasia with lower urinary tract symptoms and are commonly used in the United States in over-the-counter preparations. Saw palmetto berry is the most popular of these agents, and in vitro some studies suggest that liposterolic extract of the plant has antiandrogenic effects that inhibit the type 1 and type 2 isoenzymes of 5alpha-reductase; however there are no clinical studies that show any decrease in serum dihydrotestosterone or prostate-specific antigen. Its efficacy in the treatment of lower urinary tract symptoms has not been conclusively proven. Clinical efficacy was suggested by a meta-analysis of Permixon, a formulation of saw palmetto, but the meta-analysis was done on suboptimal studies. One trial supports the equivalency of Permixon to finasteride in treating moderate to severe symptoms of benign prostatic hyperplasia, with less decrease in sexual function. However, without a control/placebo arm, the actual efficacy of the agents cannot be determined. Other than occasional gastrointestinal upset, no other side effects have been reported.

Journal Article↗
PubMed2000

Phytotherapy for chronic prostatitis.

Chronic prostatitis is a poorly defined condition that is difficult to treat; there are therefore multiple therapies. Although there is a paucity of trials using phytotherapeutic agents, plant extracts have been postulated to have anti-inflammatory effects that might be useful in the treatment of chronic prostatitis. More placebo-controlled trials of longer duration in this condition are needed to ascertain whether there is a significant benefit to the use of phytotherapeutic agents for chronic prostatitis.

Chronic Disease↗
PubMed1998

Phytotherapy in the treatment of benign prostatic hyperplasia.

There are numerous plant extracts that have been used for the treatment of benign prostatic hyperplasia and voiding dysfunction. While some extracts show promise, their efficacy has not been adequately proven in long-term, double-blind, placebo-controlled trials. In addition, the mechanism of action remains poorly defined.

Journal Article↗