THE INCREASE IN BETA-GLUCURONIDASE OF THE TADPOLE TAIL DURING ANURAN METAMORPHOSIS AND ITS RELATION TO LYSOSOMES.
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Biomedical subjects
Publications and source records attributed to E FRIEDEN.
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Anuran metamorphosis is accompanied by changes in the sedimentation patterns of the lysates of red blood cells of several species. Rana grylio and Rana catesbeiana tadpoles have hemoglobins that sediment at 4.3S (molecular weight, 68,000) and gradually produce a heavier 7.0S component (estimated molecular weight, 136,000) during metamorphosis to the adult frog. There is extensive change in the amino acid compositions of these hemoglobins; these changes may account for observed changes in electrophoretic mobility.
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The abnormally high thyroxin-like activity of certain thyroxin analogs is due to the use of the unique test route of immersion. When thyroxin, triiodothyronine, and their propionic and acetic acid analogs are tested by injection into the tadpole, their activities are more comparable to activity levels established in rat and man.
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