[Interaction between paroxetine and clomipramine as a possible reason for admission to a department of internal medicine].
A 79-year-old woman was admitted due to increasing dizziness during the past six days. She had been treated with clomipramine 75 mg daily for years, and in addition had received paroxetine 20 mg daily for the last eight days. Both drugs were terminated and the symptoms disappeared. Thirty-six hours after taking the last drugs, the S-clomipramine plus S-desmethylclomipramine were 790 mmol/l. The symptoms were probably related to this high serum level caused by interaction with paroxetine.
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