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Biomedical subjects

E F Sherertz

Publications and source records attributed to E F Sherertz.

88 records · Page 5Linked to original sources
PubMed1987

Improvement of chronic neurotic excoriations with oral doxepin therapy.

Two patients with 6- to 7-year histories of neurotic excoriations refractory to the usual dermatologic management were referred for evaluation. Both had symptoms and signs of depression associated with the onset and persistence of the skin condition. Doxepin, a tricyclic antidepressant therapy with potent antihistamine properties, was used in oral doses of 30-75 mg daily for our patients. This therapy resulted in symptomatic and clinical improvement in both patients within several weeks. This limited report of apparent benefit of doxepin in two patients with neurotic excoriations and depression offers a potential therapy in the management of this challenging clinical problem.

Administration, Oral↗
PubMed1987

Delayed reactivation of sunburn by methotrexate: sparing of chronically sun-exposed skin.

A 60-year-old man with metastatic transitional cell carcinoma of the bladder was treated with weekly methotrexate injections, each followed by leucovorin rescue. After two to three hours of sun exposure, he experienced a mild sunburn erythema on his lower extremities in areas not chronically sun exposed. He received methotrexate the next day. More than one week later, following another dose of methotrexate, he experienced a second-degree burn in the areas of the prior sunburn, with sparing of chronically exposed areas on his face, neck, and arms. We discuss here the reactivation and exacerbation of sunburn by methotrexate and other chemotherapeutic agents, the unique features of delayed onset and selective skin involvement in our case, and the need for sun protection in patients receiving these drugs.

Drug Hypersensitivity↗
PubMed1986

Transfer of hepatitis B virus by contaminated reusable needle electrodes after electrodesiccation in simulated use.

Reusable needle electrodes have been standard for electrodesiccation procedures commonly done by dermatologists. This study investigates the risk of transmission of hepatitis B virus by such electrodes during simulated use with electrodesiccation. Sterile needle electrodes were inoculated with either purified hepatitis B surface antigen (HBsAg+) concentrate or serum positive for both HBsAg and deoxyribonucleic acid (DNA) polymerase activity (a measure of infectious and replicating hepatitis B virus), followed by simulated use for electrodesiccation at various settings and rinsing of the tip with negative serum. The rinse serum was then assayed for HBsAg, DNA polymerase activity, and the presence of viral particles by electron microscopy. HBsAg could be transferred through the electrodesiccation procedure at all settings used. Although DNA polymerase activity was negative in the rinse serum, electron microscopy demonstrated transfer of HBsAg forms and complete virus. These results suggest a potential risk of spread of hepatitis B virus by reusable needle electrodes for electrodesiccation.

Electrocoagulation↗
PubMed1986

Dystrophic calcinosis cutis secondary to intrauterine herpes simplex.

A neonate had numerous positive skin cultures for herpes simplex virus (HSV) as well as associated abnormalities strongly suggestive of a maternal intrauterine infection. In addition, he was noted to have dystrophic calcinosis cutis involving the back and buttocks. We believe the dystrophic calcinosis cutis occurred as a consequence of the HSV infection.

Adult↗
PubMed1986

Sun protection in well-child care: results of a survey of Florida pediatricians.

Chronic sun exposure has been linked to induction of skin cancers including melanoma and aging changes of the skin, has an adverse effect on certain diseases such as lupus erythematosus and is responsible for drug-induced phototoxic reactions. A majority of an individual's lifetime sun exposure may occur during childhood, and thus early photoprotection is desirable. We conducted a written survey of Florida pediatricians regarding their inclusion of sun protection information as part of routine well-child care. The results indicated that a majority of the pediatricians have awareness of the need for parent and patient education about sun-related issues, and most (65%) requested further information and educational materials. This study suggests that expanded educational efforts concerning sun-related health hazards and sun protection would be desirable for physicians involved in pediatric care, for parents, and for children.

Child↗
PubMed1986

Sarcoidal reaction to lymphoma presenting as granulomatous rosacea.

A patient with poorly differentiated lymphocytic lymphoma had rosacealike facial lesions noted at the time of diagnosis of the lymphoma. The skin lesions followed the course of exacerbations and remissions of the systemic lymphoma. A biopsy specimen showed a sarcoidal granulomatous inflammation in the skin, and later in subcutaneous nodules that developed on the face. This case is consistent with a sarcoidal tissue reaction to lymphoma, and is unique in its clinical presentation as granulomatous rosacea.

Humans↗
PubMed1985

Immunologic disorders of the skin and mucous membranes.

This article provides a practical approach to those dermatologic disorders in which an immunologic mechanism is involved in the pathophysiology. There is a brief discussion of evaluation and management for many of these disorders.

Autoimmune Diseases↗
PubMed1985

Phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Report of a patient treated with corticosteroid "pulse therapy".

In this report we describe the successful outcome following the use of corticosteroid pulse therapy in a patient with a severe phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Steroid pulse therapy may be lifesaving in a severe dermatosis, such as toxic epidermal necrolysis.

Chemical and Drug Induced Liver Injury↗
PubMed1985

Harmful effects of indoor tanning.

The new indoor tanning units use predominantly ultraviolet A radiation, which has less potential than ultraviolet B for causing acute sunburn but more potential for photosensitivity reactions. Effects of long-term exposure to ultraviolet A may include dermal degenerative changes and predisposition skin cancer.

Advertising↗
PubMed1984

Pigmented purpuric eruptions.

The pigmented purpuric eruptions most likely represent a group of clinical patterns of erythrocyte extravasation due to pericapillary inflammation. This inflammatory reaction may be in response to an immunologic reaction of some type, as suggested by immunopathologic studies and by the drug-induced pigmented purpuras. It is important to recognize this group of cutaneous purpura primarily to distinguish the pigmented purpuric eruptions from other types of purpura which are associated with systemic illness. The various eponyms or descriptive types of the pigmented purpuric eruptions are of historical and dermatologic interest; there is little clinical use in distinguishing among the types for a given patient.

Adult↗
PubMed1982

The biology of basal cell carcinoma: a review.

Features of basal cell carcinoma are reviewed within the broad categories of growth characteristics, histogenesis, ultrastructural features, biochemical properties, site of origin, metastatic potential, and immunobiology. Biologic features that pertain to host-tumor interactions are emphasized. Perhaps a better understanding of these host-tumor relationships will offer more effective methods of treating and preventing these neoplasms in the future.

Basal Cell Carcinoma↗
PubMedDate not supplied

Practical issues in conducting pharmacoeconomic studies.

Many difficulties are inherent to pharmacoeconomic studies. Because these studies are observational, there are many factors that cannot be controlled; for example, there are many variations across the country in the practice of any particular therapy. Therefore, designing a case report form that will match the source documents from various investigator sites is not easy. Issues arise in every activity such as choice of investigator site, data collection, data analysis, and interpretation of the results. These issues will be discussed, and an example of a pharmacoeconomic study conducted to evaluate the cost-effectiveness of patch testing in patients diagnosed with allergic contact dermatitis will be presented.

Clinical Trials as Topic↗