Search PubMed⌕ Search

Biomedical subjects

E F Sherertz

Publications and source records attributed to E F Sherertz.

At least 55 records · Page 3Linked to original sources
PubMed1994

Congenital "self-healing" Langerhans cell histiocytosis: the need for long-term follow-up.

Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare disorder initially seen at birth or in the newborn period with spontaneously involuting skin lesions. In contrast to other forms of Langerhans cell histiocytosis in infancy, such as Letterer-Siwe disease, the prognosis of CSHLCH is generally good. We describe four children with widespread CSHLCH at birth. In all patients a congenital infection was initially suspected. All patients, except one who had transient lower extremity edema and pulmonary symptoms, had an uncomplicated neonatal course, and in all patients skin lesions resolved spontaneously. Two patients showed no further evidence of disease, but one had a cutaneous relapse at age 3 months, and in another a bony relapse that required systemic therapy developed at 6 months of age. CSHLCH is usually a benign, self-limited condition, but careful evaluation for systemic disease must be performed. Long-term follow-up for evidence of relapse or progression of disease is essential.

Female↗
PubMed1994

Occupational skin disease in the pharmaceutical industry.

As with other chemical-based industries, the pharmaceutical industry has the potential for innumerable irritants and allergens. Prompt reporting and recognition of employees' skin diseases, with clarification of the triggering factors, can lead to appropriate control and prevention in many situations.

Dermatitis, Allergic Contact↗
PubMed1993

Stated age.

Explore the source record for details and available documents.

Adult↗
PubMed1993

Periparotid lupus erythematosus panniculitis. Clinicopathologic correlation of two cases presenting as primary parotid disease.

Lupus erythematosus (LE) panniculitis, also called lupus profundus, is an uncommon but well-established manifestation of both chronic cutaneous (discoid) LE and systemic LE. Although LE panniculitis characteristically may involve the face, specific parotid and periparotid involvement has not, to the best of our knowledge, been previously reported. We describe the clinicopathologic correlation of two cases of LE panniculitis that presented as apparent primary parotid parenchymal disease; one as a neoplasm, the other as parotiditis. Failure to recognize LE panniculitis resulted in prolonged periods of inappropriate therapy and significant morbidity, including an unnecessary parotidectomy. Lupus erythematosus panniculitis has well-established histologic criteria that should be considered in the differential diagnosis of an unexplained parotid mass.

Adult↗
PubMed1993

The technique of patch testing: role of the office staff.

Patch testing is a very useful office diagnostic tool to help clarify the cause of allergic contact dermatitis. The dermatology nursing staff can help the physician with some of the time-consuming steps in using this technique, which can be very valuable to patient outcome.

Dermatitis, Contact↗
PubMed1992

Eyewear, cataracts, and periorbital basal cell carcinoma.

Ultraviolet exposure is an important risk factor for basal cell carcinoma. Since eyewear may have a photoprotective effect, this study evaluated the use of prescription eyeglasses and sunglasses in patients with periorbital basal cell carcinoma compared with other facial sites. There was no difference in prescription eyewear use between the groups, and only four patients in each group had regularly worn glasses since childhood. There was an increased occurrence of cataracts and cataract surgery in the group of patients with periorbital tumors, which may indicate a greater cumulative ultraviolet exposure to the orbital and periorbital sites in these patients.

Basal Cell Carcinoma↗
PubMed1991

Papular dermatitis in adults: subacute prurigo, American style?

Determining the best treatment for recurrent pruritic papular eruptions that do not fit well into a diagnosis (of either atopy or some other diagnosis) is sometimes frustrating. We have studied 12 patients with recurrent pruritic papular eruptions by obtaining extensive histories and by performing skin biopsies, immunofluorescence studies, and screening patch tests. The eruptions in this group are not atopic by strict criteria but have atopic features and are without a determinable exogenous cause. Histologic features resemble papular urticaria, but there is no history to suggest arthropod bites. Patients with this type of eruption have features similar to those with subacute prurigo, and they respond to variable combinations of topical or systemic corticosteroids, systemic antihistamines, and UVB or UVA. We suggest that the designation of subacute prurigo might be more appropriate for patients with these findings.

Acute Disease↗
PubMed1991

Low-dose weekly methotrexate for unusual neutrophilic vascular reactions: cutaneous polyarteritis nodosa and Behçet's disease.

Low-dose weekly methotrexate therapy has been used to treat patients with psoriasis for more than 20 years. This regimen has also been used to treat rheumatoid arthritis, inflammatory bowel disease, primary sclerosing cholangitis, and corticosteroid-dependent asthma. We report two patients with Behçet's disease with cutaneous neutrophilic vascular reactions and three with cutaneous polyarteritis nodosa who responded dramatically to low-dose weekly methotrexate therapy.

Administration, Oral↗
PubMed1991

Severe allergic keratoconjunctivitis and erythema multiforme after a routine eye examination: discerning the cause.

Acute allergic dermatitis of the eyelids with keratoconjunctivitis is associated with a specific triggering factor. Therapy for the acute inflammation can complicate the search for such a factor if the process worsens. We report a case of acute contact dermatitis and keratoconjunctivitis after a routine eye examination to demonstrate the difficulty in evaluating such patients and the role of skin patch testing in determining the cause.

1-Propanol↗
PubMed1991

Acneiform eruption due to "megadose" vitamins B6 and B12.

Medications and other exogenous factors are known to be capable of exacerbating acne or precipitating acneiform eruptions. This case illustrates an eruption resembling acne rosacea that was temporally associated with daily ingestion of high-dose B vitamin supplement. The eruption failed to respond to the usual treatment regimens for rosacea, but promptly improved when use of the vitamin supplement was discontinued.

Acne Vulgaris↗
PubMed1991

Perplexing pigmented papules simulating malignant melanoma.

The clinical presentation of irregularly pigmented papules raises a spectrum of diagnostic possibilities. An eighty-five-year-old black man was referred for evaluation of lesions of fifty years' duration. The lesions were 1 to 2 cm hyperkeratotic, irregularly darkly-pigmented papules limited to sun-exposed areas. The histopathologic findings of large keratinocytes, acanthosis, hypergranulosis, and orthokeratosis were compatible with a diagnosis of large cell acanthoma. We believe large cell acanthoma should be included in the differential diagnosis of keratotic or irregularly pigmented lesions on sun-exposed skin, even in black patients.

Aged↗
PubMed1990

Transdermal delivery of 5-fluorouracil through skin of hairless mice and humans in vitro: a comparison of the effect of formulations and a prodrug.

A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while changes in the total suspended concentration of 5-FU in propyleneglycol (PG) had no significant effect on transdermal delivery by those suspensions. A prodrug of 5-FU/IPM was significantly better at delivering 5-FU than any of the formulations. The trends in relative rates of delivery of 5-FU by the formulations and the prodrug were the same in skin of hairless mice and humans. The mouse skin was about ten times more permeable than the human skin. Second application studies to assess skin damage caused by the formulations also showed the same trend in skin of hairless mice and humans: all of the formulations caused some damage.

Administration, Cutaneous↗