Cellular immunity towards Thomsen-Friedenreich antigen in breast-carcinoma patients.
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Biomedical subjects
Publications and source records attributed to E F Scanlon.
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This report describes our experience with a technique of modified radical mastectomy involving incision of the lower lateral fibers of the pectoralis major muscle and detachment of the origins of the pectoralis minor muscle. These maneuvers enable sufficient retraction of these muscles to provide excellent axillary exposure while minimizing the danger of traction injury to the neurovascular structures supplying these muscles. The operation has been performed in 20 patients; statistical analysis demonstrates at least as many nodes in these specimens compared to retrospective analysis of nodes recovered from 223 radical mastectomy specimens done during the previous 5 years. The final cosmetic results are superior to those obtained with standard radical mastectomy. These results suggest that this method of modified radical mastectomy should be considered, unless the proximity of the disease to the pectoralis muscles endangers the adequacy of the surgical margins.
Obstruction of the extrahepatic bile ducts by primary or metastatic carcinoma can sometimes be diffiult to relieve. Frequently there is an inadequate length of normal duct proximal to the obstruction to permit an anastomosis. A by-pass anastomosis between a dilated right hepatic biliary radicle and the gallbladder is a simple and satisfactory method of relieving the jaundice. This can be accomplished by using a T-tube as a stent; a vein graft over the T-tube limb in the liver seems to improve the result.
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A retrospective review of 143 patients with head or neck tumors who had received radiation therapy in the head and neck area for benign conditions during childhood or adolescence was conducted. This included an analysis of 1,080 patients from the Evanston Hospital Irradiated Thyroid Evaluation Clinic, which was established to define the relationship between irradiation and the subsequent development of thyroid neoplasia. The data support the following concepts of irradiation-induced neoplasia: (1) The thyroid, parathyroid, and salivary glands can develop benign and malignant changes after irradiation for benign conditions, with latent periods averaging about 30 years; (2) Once a glandular abnormality within the irradiated field appears, the risk of other glands in the field developing neoplastic changes is significantly increased.
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Until recently surgical ablation was the primary treatment of choice for operable breast cancers. Increasingly, this position has been challenged by concepts of lesser surgical procedures coupled with radiotherapy. The trend of recurrence rates suggests that wide local excision of the primary tumor followed by irradiation may give as good results as more extensive surgical procedures. Long-term evaluation of morbidity, treatment time, and costs, must also be included in these comparisons. One of the more attractive features of these lesser procedures is the improved cosmetic result. Good cosmetic results after modified radical mastectomy require a greater appreciation of the importance of the anterior thoracic nerves to prevent atrophy of the pectoral muscles. Adjuvant therapy after mastectomy needs to be evaluated in greater detail. Radiotherapy prevents local recurrence but does not affect the tumor-free interval or survival rates. Adjuvant chemotherapy prolongs the tumor-free interval but its effect on survival rates is not yet known.