[Radiation pathomorphosis of laryngeal cancer].
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Biomedical subjects
Publications and source records attributed to E F Lushnikov.
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The paper discusses methodological aspects of radial pathomorphism of human tumors. Its main feature is a type change of clinico-anatomical features of some nosological forms of malignant tumors under the influence of radiation therapy. Morphological manifestations of radial pathomorphism are variable, but its criteria require systematization. The development of radial changes occurs step-wisely and is characterized by structural-functional rearrangement of the tumor and circumflex normal tissues.
The paper presents a review of the literature on fundamentals of morphometry, describing morphometric parameters and their designations, as well as the use of morphometry in medical and biological investigations conducted by light and electron microscopy.
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Histological and cytological studies of preparations of peripheral lymphatic nodes in 1081 patients before treatment were carried out. In 76 patients there were also investigated morphological changes in the spleen, mesenteric lymphatic nodes and parts of the liver obtained in laparotomy. Basing on the analysis of the literature and their own findings, the authors think it reasonable to single out the following 8 histological variants of untreated lymphogranulomatosis: focal lesion; a group of variants with nodular sclerosis, with various cellular composition--lymphocytic predominance, mixed cellularity, predominance of lacunar cells; a group of variants without sclerosis consisting of lymphoid predominance and mixed cellular variant; a group of lymphatic depletion combining the reticular variant and diffuse fibrosis. The variants indicated above may be both independent and transitional stages.
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The authors report clinica, roentgeno-lymphographic and morphological findings in 164 patients whom lymph nodes showed various changes of non-tumor origin, 584 lymph nodes being studied by aimed lymphographic and morphological correlations. The changes observed were subdivided into 2 groups: diffuse and focal. Diffuse inflammatory and reactive changes, and multiple micrometastases as well, are manifested by an analogous lymphographic picture. In focal hyperplasia a lymph node is somewhat increased in size, it shows smooth and distinct contours, defects of filling and absorption.
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