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Biomedical subjects

E Erdmann

Publications and source records attributed to E Erdmann.

454 records · Page 26Linked to original sources
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Heart transplantation: hemodynamics over a five-year period.

Long-term hemodynamic evaluation after heart transplantation has rarely been reported. Fifty-seven heart transplant recipients (mean age, 42.1 years: range, 22 to 56 years) were investigated with annual cardiac catheterization. Mean follow-up was 2.2 years (range, 1 to 7 years). Years 1 through 5 were evaluated statistically. Hemodynamic variables did not change significantly during the 5-year period. Mean aortic pressure (105 +/- 16 to 115 +/- 17 mm Hg, minimum and maximum annual average value +/- SD of the 5-year period) and LVEDP (13 +/- 6 to 15 +/- 7 mm Hg) were slightly elevated. Borderline values were found for mean pulmonary artery pressure (18 +/- 4 to 21 +/- 5 mm Hg), systemic vascular resistance (1407 +/- 227 to 1487 +/- 409 dynes.sec.cm-5), pulmonary vascular resistance (86 +/- 42 to 118 +/- 66 dynes.sec.cm-5), and heart rate (85 +/- 17 to 95 +/- 14 beats/min). Mean right atrial pressure (5 +/- 2 to 8 +/- 4 mm Hg), cardiac index (2.8 +/- 0.6 to 3.5 +/- 1.1 L/min/m2), end-diastolic volume (111 +/- 37 to 137 +/- 35 ml) and ejection fraction (69% +/- 10% to 75% +/- 9%) were in the normal range. Pressure-volume loops for each year excluded the development of either restrictive or dilated cardiomyopathy with time. Contractility, as measured by imposing afterload stress, was normal in 12 of 14 representative patients. Prevalence of coronary abnormalities (circumscript coronary stenoses, diffuse vessel obliteration or dilated angiopathy) increased from 14.9% in the first to 66.7% in the fifth year. Of the patients, 93% received antihypertensive drugs.(ABSTRACT TRUNCATED AT 250 WORDS)

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Dilated angiopathy: a specific subtype of allograft coronary artery disease.

Dilated coronary angiopathy exceeding the diameter of adjacent vessel segments by at least 50% was found in five of 68 heart transplant recipients undergoing coronary angiography greater than or equal to 1 year after heart transplantation. Severely delayed washout of the contrast medium from the dilated segments indicated local stasis. Dilated angiopathy was not combined with tubular narrowing of distal vessel segments or with focal eccentric lesions of the same artery. On the average, hemodynamic data were normal except in one patient. Signs of myocardial ischemia were not present on ECG and treadmill exercise testing. Age of the donor heart, ischemia time of the graft, prevalence of myocardial rejection episodes, cyclosporine dosage, and cholesterol serum levels did not differ from the whole group. We conclude that dilated angiopathy of the allograft is a specific subtype of the immune-mediated chronic vascular injury after heart transplantation that has not been described. The pathogenetic mechanisms for these findings are unknown. Although prognosis seems to be better in comparison with the other subtypes of allograft coronary artery disease, the patients may be at risk of embolic myocardial ischemia with progression of the disease.

Adult↗
PubMedDate not supplied

International comparison of awareness and attitudes towards coronary risk factor reduction: the HELP study. Heart European Leaders Panel.

BACKGROUND: An international survey was conducted to assess public awareness and attitudes to coronary heart disease and to establish the frequency with which certain health-related behaviours are practised in five European countries. METHODS: Members of the general public (n=5013), individuals at increased risk of coronary disease (n=2500), patients who had suffered a myocardial infarction (n=1256) and members of their families (n=1249) were interviewed in a study conducted in France, Germany, Italy, Sweden and the UK. Questions were asked about respondents' attitudes to their health and about their current health practices. RESULTS: The survey revealed a considerable degree of indifference to coronary heart disease, despite the possession of a reasonable level of knowledge of the risks involved, even among patients who had suffered a myocardial infarction. At the same time, respondents declared themselves satisfied with the quality of advice about coronary health that they obtained from the medical profession and regarded these sources of information as highly credible. Media health campaigns, by contrast, had comparatively little impact. CONCLUSION: A survey of five European countries shows that individuals possess reasonable levels of knowledge about coronary heart disease. They also have access to sources of heart health information that are perceived as highly credible. Nonetheless, such information has a very limited impact on their practice of health-related behaviours.

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