PURPOSE: This study had a twofold aim: first, to gather knowledge about the prevalence of radiologic signs of temporomandibular joint osteoarthritis (TMJ-OA) and possible risk factors in patients who had worn an implant prosthesis for between 2.5 and 10 years; and second, to investigate the diagnostic value of radiologic TMJ-OA signs for orofacial pain in a non-temporomandibular disorders group. MATERIALS AND METHODS: Two hundred thirty patients (134 women, 96 men) answered a questionnaire regarding orofacial pain. In mean, they were 64 years old and wore 98 fixed and 132 removable implant dentures. The effect of age, gender, state of the dentition, time span after prosthesis placement, parafunction, and TMJ sounds on radiologic TMJ-OA signs was estimated through multiple logistic regression. The predictive values were calculated to assess the diagnostic value of severe TMJ-OA signs to predict orofacial pain. RESULTS: Prevalence of TMJ-OA signs was 70% for flattening, 23% for osteophytes, and 24% for erosion. Some effect on radiologic TMJ-OA signs of gender and state of the dentition was found. The predictive values for orofacial pain from radiologic TMJ-OA ranged from 0.22 to 0.81. CONCLUSION: Radiologic signs of TMJ-OA were common findings. The study gave no indication that long-term wearing of an implant prosthesis has a negative effect on TMJ-OA. It was not possible to predict orofacial pain from radiologic TMJ-OA signs.

Adult↗

PubMedDate not supplied

Effect of occlusal wear on bone loss and Periotest value of dental implants.

PURPOSE: Occlusal overload may contribute to the loss of osseointegration of oral implants, so some clinicians are reluctant to place implants in patients with signs of bruxism. This study evaluated the effect of occlusal wear as a probable sign of bruxism on bone loss and implant stability. MATERIALS AND METHODS: The study investigated 379 patients who had worn implant-retained or implant-supported restorations for many years. Occlusal wear, patient age and gender, time of prosthetic loading, jaw, location in the dental arch, implant diameter, prosthesis construction, occlusal material, periimplantitis, and loosening of the prosthetic construction were recorded. One implant from each patient was selected for radiographic and Periotest measurements. The implant with the highest bone resorption was chosen. A forward stepwise multiple linear regression analysis was performed to analyze the effect of the explanatory variables on Periotest value and radiographic bone loss. RESULTS: The statistical models could account for part of the variation in bone loss rate and Periotest value. Some influence of time of loading, jaw, and implant diameter on bone loss or Periotest value was formally established. Occlusal wear failed to have any statistical impact on vertical annual bone loss rate or Periotest value. CONCLUSION: This study gave no indication that implants in patients with occlusal wear have an increased bone loss rate or Periotest value.

Adult↗

PubMedDate not supplied

Alteration of melanoma cell phenotype following in vitro culturing and exposure to cytostatic agents.

Pleiotropic drug resistance is supposed to be associated with a particular tumor cell phenotype, defined by certain plasma membrane glycolipids. Therefore we wondered how far chemosensitivity in vitro correlates with phenotypic characteristics of melanoma cells, which are known to be highly refractory to cytocidal agents. 13 monolayer cell cultures of metastatic melanoma derived from 9 patients were tested with 12 monoclonal antibodies against constitutive, differentiation- and progression-associated antigens. In parallel these primary cell cultures were subjected to a proliferation inhibition assay in the presence of dacarbazine, cis-platinum and carboplatinum. Transferring melanoma cells from original tissue-suspensions into short-term monolayer cultures caused a change in the expression of certain tumor antigens in 54% of 104 assays. In addition, the incubation of the cultivated cells with various cytostatic agents caused them to alter their phenotype in 32% of 128 assays. Irrespective of the spontaneous or induced changes in the antigen patterns, cells lacking HLA-ABC and/or HLA-DR were inhibited more markedly by cytostatic agents as compared to those other cells expressing these antigens. The data suggest, that pretherapeutic determination of tumor cell phenotype may provide clinically useful information for therapeutic decisions in patients with metastatic melanoma.

Antibodies, Monoclonal↗

PubMedDate not supplied

The larynx in the cri du chat (cat cry) syndrome.

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Adolescent↗

PubMedDate not supplied

[Klinefelter's syndrome with 46-XX karyotype at the cutaneous, blood and testicular levels].

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Adult↗

PubMedDate not supplied

Changes in chewing patterns after implantation in the edentulous mandible.

Almost all edentulous patients with implant-supported prostheses in mandibles describe an improvement in their chewing function and quality of life. This was reason to believe that an implant prosthetic treatment actually influences mandibular border movements, as well as the chewing patterns. The present study compares border movements and chewing patterns in 15 patients recorded with the Sirognathograph. The first measurements were made with existing complete dentures. After implantation and rehabilitation with a Dolder-bar and clip-to-bar overdenture, the movements were recorded again. The measurements revealed an improved guidance of the mandibular movements and larger borderline patterns following stabilization of the complete denture with the bar. This leads to more harmonic shapes in the movements and better chewing efficiency.

Aged↗

PubMedDate not supplied

Treatment of edentulous patients with temporomandibular disorders with implant-supported overdentures.

Treatment of edentulous patients who have temporomandibular disorders is difficult because of the poor stability of their conventional complete dentures. With an implant-supported bar and a clip-to-bar overdenture, mandibular dentures can be stabilized. The results of a prospective clinical study of 10 edentulous patients with temporomandibular disorders and treatment with implant-supported overdentures in mandibles are presented. Before and after 3 years of wearing the implant-supported overdentures, patients were interviewed and a clinical functional analysis was taken. Patients with displacement of the articular disc or bone destruction of the joints had a decrease in pain, an enhanced mobility of the mandible, and a decrease in temporomandibular joint sounds. Patients with pain of muscular genesis as a result of bruxism suffered after 3 years from the same pain and did not show an improvement of muscle or joint sensitivity.

Aged↗