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Biomedical subjects

E Elian

Publications and source records attributed to E Elian.

At least 37 records · Page 2Linked to original sources

Latent viruses and Bell's palsy in children.

4 children with unilateral facial palsy--Bell's palsy (BP)--had serological evidence of primary infection with Epstein-Barr virus (EBV). Concomitant infection with cytomegalovirus (CMV) was demonstrated in 1 child while in all 4 children a rise in antibody titers to an additional one or two viruses was demonstrated. The viruses involved were herpes simplex, CMV and adenovirus which are latent in humans. Immunosuppression induced by EBV and steroid treatment may cause reactivation of these viruses resulting in rise in antibody titers. The need for prolonged serological follow-up for possible reactivation of latent viruses in BP is emphasized.

Adenoviridae↗

Role of fetal adrenal glands. A contribution to the etiology and mechanism of fetal pulmonary maturation.

The role of fetal adrenals in the maturation of fetal lungs is not clear as yet. The anencephalic baby, with rudimentary adrenal glands, may be considered an excellent model for the study of this subject. The maturation of fetal lungs was determined in 3 anencephalic monsters and in 2 microencephalic babies. As a measure of fetal pulmonary maturation the foam test and lecithin/sphingomyelin ratio (L/S) were used, as determined in the amniotic fluid. In the anencephalic babies, fetal pulmonary maturation was lacking, while in the microencephalic infants there were definite signs of lung maturation.

Adrenal Glands↗

Failure of determination of fetal lung maturation due to false-negative lecithin/sphingomyelin ratio in a case of pierre robin syndrome.

A case is reported of a baby with Pierre Robin syndrome born at term with adequate lung maturity. The evaluation of fetal lung maturity before birth by means of the lecithin/sphingomyelin ratio and foam test in the amniotic fluid revealed immaturity of the lungs. Examination of the tracheal aspirate following delivery, however, showed adequate lung maturity in the neonate.

Amniotic Fluid↗

LH-RH and HCG studies in a Turner phenotype male (Noonan's syndrome). A case report.

LH-RH and HCG stimulation tests were performed in a prepubertal 13-year-old boy with Noonan's syndrome. The basal plasma LH (0.8 mIU/ml) was normal and FSH (2.5 mIU/ml) high, with an elevated response of both LH (8.3 mIU/ml) and FSH (9.6 mIU/ml) to LH-RH, as seen in primary hypogonadism. However, the patient had a normal testosterone response to HCG (437 ng%). These conflicting test results illustrate the difficulty of predicting potential for fertility in patients with Turner phenotype male.

Adolescent↗

Ultrastructural changes in aspirin hepatotoxicity.

A percutaneous liver biopsy was obtained from a 9-year-old boy who had elevated serum transaminase levels while receiving aspirin treatment for rheumatic fever. Electron microscopy showed extensive fine-structure changes of the hepatocytes, similar to those induced by hepatotoxic drugs. These included marked dilatation of rough endoplasmic reticulum, proliferation of smooth endoplasmic reticulum, and mitochondrial abnormalities. These ultrastructural changes could be considered evidence that aspirin is hepatotoxic. The morphologic observations reported confirm the need for monitoring patients receiving systemic aspirin treatment transaminase measurements.

Aspirin↗

The intestinal microvillus. Ultrastructural variability in coeliac disease and cow's milk intolerance.

In 8 patients with coeliac disease, 2 patients with cow's milk intolerance and 10 patients with other gastrointestinal disturbances, intestinal biopsies were examined in order to compare the extent of alteration of surface vs. crypt microvilli (MV). In those diseases associated with the ingestion of a noxious agent, namely coeliac disease and cow's milk intolerance, a marked and abrupt difference between the severely damaged surface epithelium and its MV, and the preserved crypt epithelium was noted. The results of the examinations give reason to suppose that these morphological variations are caused by the higher gliadin or milk protein concentration over the avillous surface epithelium as opposed to the lower one in the elongated crypts.

Adolescent↗

Incontinentia pigmenti.

Four new cases of incontinentia pigmenti are presented, including chromosome studies of one family. An increased number of chromosome breakages was found in the blood of affected as well as unaffected members of this family.

Abnormalities, Multiple↗

Case report: infantile sub-lobar emphysema and tracheal bronchus.

Localised disturbance of aeration in children is as often the result of mucosal swelling due to infection as resulting from an inhaled foreign body. The present report adds another cause: tracheal bronchus. Elucidation of this cause of localised disturbance of aeration usually includes bronchoscopy, the anesthesia and direct trauma involved being highly undesirable if i infection is the cause. The case for limited, careful bronchography, before or instead of bronchoscopy, when the history of foreign body is lacking is presented.

Ampicillin↗