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Biomedical subjects

E Eidelberg

Publications and source records attributed to E Eidelberg.

At least 73 records · Page 4Linked to original sources
PubMed1967

Penetration of sugars across the blood-brain barrier.

1. A cerebral perfusion method was used to measure the net uptake of arabinose from the circulatory system in cats.2. There was found to be discrimination between the optical isomers of this substance, with apparently greater uptake of the (-)-form.3. The uptake process was highly temperature dependent, with a Q(10) of 3.0.4. The uptake of arabinose was partially inhibited by 1 mM ouabain perfused concurrently. It was not significantly inhibited by dinitrophenol or phlorrhizin.5. Glucose inhibited competitively the uptake of (-)-arabinose.6. We conclude that the mechanism involved is of the carrier-mediated or of the active transport type, and that at least part of it is shared with glucose and probably other sugars.

Animals↗
PubMedDate not supplied

Genetically determined differences in the effects of morphine on mice.

We have compared a variety of well known behavioral actions of morphine across four strains of laboratroy mice. Thes measures included locomotor activation, analgesia, tolerance, dependence and drug-seeking. We found that analgesia and drug-seeking did not vary greatly among strains, although some statistically significant differences were found. The interstrain rank ordering for locomotor activity, tolerance and dependence was different for each of these measures. This suggests that each of these effects of morphine may depend upon separate mechanisms, perhaps with each under independent genetic control. Other experiments were carried out to determine whether or not there were differences in the in vivo brain uptake of an opiate or the in vitro binding of naloxone to 'stereospecific receptors'. No significant interstrain differences could be found.

Analgesia↗