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Biomedical subjects

E Edwards

Publications and source records attributed to E Edwards.

At least 91 records · Page 5Linked to original sources
PubMed1983

Cholinergic receptor site binding, choline acetyltransferase, and acetylcholinesterase activity in the forebrain and brainstem of the Dahl rat model of essential hypertension.

Muscarinic and nicotinic receptor site binding and the activity of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the forebrain and brainstem of Dahl salt-sensitive (DS) and salt-resistant (DR) rats was investigated. The DS line had a greater density of muscarinic sites in the cortex, hypothalamus, and medulla. Hypertensive DS rats had a greater density of sites than normotensive DS rats. ChAT activity was also higher in the cortex and hypothalamus of the DS line than the DR line. No significant differences were found in the activity of AChE or the concentration of nicotinic sites. These results suggest that the central muscarinic cholinergic system may participate in the pathogenesis of hypertension in the DS rat. The data indicate that central cholinergic activity is possibly greater in the DS than the DR rat and that this may help to explain the enhanced pressor response in the DS line after pharmacological activation of the central cholinergic system.

Acetylcholinesterase↗
PubMed1981

Increasing utilization of a rural cervical cancer detection program.

The Alabama Department of Public Health established, in 1973, a Cancer Screening Program (CSP). Although 66,000 women have been screened, many rural females had never used the program. After a community health organization education effort was introduced into a target rural county, an examination of CSP new user data for two intervention quarters revealed 345 and 150 per cent increases, respectively, in the pattern of use.

Age Factors↗
PubMed1980

Mycotic aneurysm of the aorta.

The radiographic and pathologic features of 13 cases of mycotic aneurysm of the aorta were reviewed retrospectively. In four cases the mycotic aneurysm was associated with bacterial endocarditis following aortic valve replacement, and in nine cases it was associated with spontaneous bacterial endocarditis. Postmortem examination revealed that the mycotic aneurysm was most frequently found in cases with bicuspid aortic valves. In all cases the chest radiograph revealed cardiomegally, usually with pulmonary vascular congestion. In the six patients in whom the diagnosis was established angiographically, the aneurysm was manifested by an irregular saccular collection of contrast medium under one of the coronary arteries. Mycotic aneurysms must be differentiated from other lesions with similar angiographic findings, such as a congenital aneurysm of the sinus of Valsalva, prolapse of an aortic cusp through a membranous ventricular septal defect, and a congenital aortic-left ventricular tunnel.

Adult↗
PubMed1977

Automation in civil transport aircraft.

The pilot of a contemporary transport aircraft is in a managerial role, supervising the performance of sophisticated systems which perform most of the tasks concerned with operating the aircraft safely and efficiently. Under normal conditions he is required to exercise his psycho-motor skills only to a very small extent; his principal task is to process information and to convey instructions to the automatics by way of push-button switches and similar devices. In the event of major system failure, however, or in the absence of ground-based facilities, he may be called upon to take a much more active part in control. The evolution of flight-deck automation owes much more to engineering and economic analyses that to systematic development of policy concerning the role of men in automated systems. The current situation is not without its problems, and substantial ergonomics input should contribute to future developments.

Journal Article↗
PubMed1974

The influence of the process characteristics on the role of the human operator in process control.

Rational design of a process control system using an on-line computer requires a definition of the total control task and an allocation of function between the human operator and the machine. Both the nature of the total task and its subdivision depend very much on the process characteristics, which vary widely between different processes. The functions normally performed by a process control computer are described and those consequently left to the operator are defined. The wide variety of the operator's functions and the implications of this for studies of the operator's performance and for the design of the man-machine interface are emphasised. This article was originally presented as a paper at a symposium on Data Reduction, Communication and Presentation for Process Operation organised by the Institute of Measurement and Control at the University of Sussex, Brighton.

Journal Article↗