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Biomedical subjects

E Edmond

Publications and source records attributed to E Edmond.

34 records · Page 2Linked to original sources
PubMed1975

False positive infectious mononucleosis serology in epilepsy.

Positive serum tests for infectious mononucleosis (IM) unaccompanied by the clinical syndrome or blood changes characteristic of the disease were detected in 39/177 (22%) mentally subnormal patients investigated with three different commercially available IM slide tests. Slide positively was still detectable six months later in 27/35 (77%) positive reactors. Positive IM slide tests were significantly associated with anticonvulsant, primarily phenobarbitone therapy and with concomitant elevations of immunoglobulins IgG and IgM. Epstein Barr virus antibodies were not detectable in the sera of 8/38 (21%) positive slide reactors. The implications of these observations are discussed and attention is drawn to the variations in sensitivity, specificity, and comparability of different IM slide tests.

Adolescent↗
PubMed1970

Phase separation in an aqueous quaternary system.

(1) We have measured the incompatible phase separation that occurs in a polyethylene glycol-sodium dextran sulphate-sodium chloride-water system and have determined a critical point. (2) We have measured the activity coefficients of sodium chloride in critical-point concentrations of polyethylene glycol and sodium dextran sulphate respectively, and the osmotic coefficient of sodium dextran sulphate at the critical-point concentration. (3) With use of the relevant thermodynamic equations for a quaternary ionic system, we have determined the interaction coefficients between polyethylene glycol and dextran sulphate and between polyethylene glycol and sodium chloride. The former could be due mainly to volume exclusion, but the latter is too large to be explained on that basis.

Chemical Phenomena↗
PubMed1968

The osmotic behaviour of Sephadex and its effects on chromatography.

1. Sephadex in bead form shows reversible changes of inner volume when immersed in solutions of a non-penetrating solute. These changes are in accordance with the theory of Flory (1953) for the swelling of gels. This makes possible the use of single beads for measuring the osmotic pressures of polymer solutions, up to or beyond 1kg./cm.(2). 2. Measurements of the inner volume of Sephadex G-200 by equilibrium dilution, at various concentrations of dextran 500, gave values in agreement with those obtained from the dimensions of single beads. 3. Measurements by chromatography of the inner volume of Sephadex G-200 gave values that differed slightly but significantly from those obtained by the other methods. Similar small disagreements were found between the dilution and chromatographic values for bovine serum albumin measured in the presence of various concentrations of dextran 500. The major factor that affects the dependence of the chromatographic elution volume (of dextran 500) on concentration is shown to be the change of the inner volume of the Sephadex, with dynamic factors playing a minor role. 4. Contrary to the findings of Ackers (1964), the equilibrium dilution and chromatographic methods gave closely agreeing values for the distribution coefficient, K(av.), of bovine serum albumin on Sephadex G-200; this cast doubt on his explanation of the nature of chromatographic separations on Sephadex.

Animals↗
PubMed1968

An approach to the study of phase separation in ternary aqueous systems.

1. Simple thermodynamic expressions are used to describe the properties of uncharged binary and ternary polymer solutions, in particular the sedimentation equilibrium of binary systems and the osmotic pressures and ;incompatible' phase separations of ternary systems. 2. Sedimentation-equilibrium experiments were performed on four samples of dextran and two of polyethylene glycol. The critical points of the phase diagrams were determined for the mixed solutions of polyethylene glycol-dextran-water and of polyethylene glycol-bovine serum albumin-0.2m-sodium chloride solution. Osmotic pressures were measured on a single-phase mixed solution of a polyethylene glycol and a dextran. By use of the simple thermodynamic expressions consistent values of second virial and interaction coefficients for the materials used were obtained from these experiments. 3. The interpretation of the values of the second virial and interaction coefficients, on the basis of three models of molecular interaction, is discussed.

Dextrans↗
PubMed1968

Avian tuberculosis.

Explore the source record for details and available documents.

Aminosalicylic Acids↗
PubMedDate not supplied

The burden of chronic illness in local authority residential homes for the elderly.

A survey of all Part III residential homes in the Central and Southern area of Liverpool Health District examined the diagnoses and medication of 331 residents. A heavy burden of chronic illness was observed with cardio-vascular, psychiatric and orthopaedic problems being the most prevalent. Of the top 10 diagnoses, accounting for over half of all conditions, all disease instances required monitoring of their response to treatment. At least two thirds of these diseases were likely to progress, and the usual treatment of three quarters of the sample was associated with possible side-effects. This heavy burden of chronic illness in Part III residential homes implies a major need for both anticipatory and event-related medical care. These needs are unlikely to be met, given that the subtle, but significant, deterioration in the health of residents has been shown to go undetected.

Aged↗