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Biomedical subjects

E E Peacock

Publications and source records attributed to E E Peacock.

At least 19 recordsLinked to original sources
PubMed1987

Major ambulatory surgery of the plastic surgical patient.

In the final analysis, a patient who does not require any more in the way of postoperative nursing care than bed rest and administration of food, water, and pain medication should be able to have surgery in an outpatient facility as safely and successfully as in an inpatient facility. A large general plastic surgery practice in an ambulatory surgical center creates unique problems, but most of these problems are solvable and have not prevented most plastic surgeons from conducting an ever increasing volume of their work in the ambulatory setting.

Adipose Tissue↗
PubMed1984

Internal reconstruction of the pelvic floor for recurrent groin hernia.

Repeated recurrence of groin hernia is more than an anatomical derangement that any trained surgeon can correct. Attempts to improve results include application of local patches of Marlex. There are two reasons (one theoretical and one practical) why a local synthetic patch may not be as useful as total reconstruction of endopelvic fascia with a biologically active, as well as structurally strong, living material. Such a restoration can be accomplished with the entire fascia lata from one thigh utilized as a free graft extending from one pelvic wall to the other and from the symphysis to the pubic rami. The practical advantage of a single sheet of fascia extending across the pelvic floor (like an airplane wing) is that frequent medial recurrences are eliminated because there is no medial edge under which peritoneum can protrude. The theoretical advantage of a biologically active graft is based upon animal data revealing the inductive capacity of fascia in stimulating net collagen synthesis and deposition. Thirteen patients with multiple recurrences following conventional repair of groin hernia have been reconstructed with large fascia lata grafts restoring the entire endopelvic floor. Over a 5-year period no recurrences have been detected. A technique for removing the entire fascia lata from one thigh through a single transverse incision will be shown. There have not been any donor site complications and there is no disability caused by removing the fascia.

Collagen↗
PubMed1984

Zyderm.

Explore the source record for details and available documents.

Collagen↗
PubMed1983

Preperitoneal abdominal wound repair: incidence of dehiscence.

Preperitoneal abdominal wound repair in 100 consecutive patients who required midline laparotomy resulted in one case of wound dehiscence. The risk of dehiscence did not increase with the use of vertical midline abdominal incisions repaired without inclusion of the peritoneum. Avoidance of suture penetration of the peritoneum may result in a reduction in postoperative adhesions and intestinal obstruction without increasing the risk of wound dehiscence.

Abdomen, Acute↗
PubMed1978

Urinary excretion of beta-aminopropionitrile and cyanoacetic acid.

Human serum did not convert beta-aminopropionitrile (BAPN) to the deaminated, nonlathyrogenic metabolite, cyanoacetic acid (CAA). Instead, its enzymic activity for oxidizing benzylamine was inhibited by BAPN (I50 = 2 X 10(-3) M). BAPN was found in the urine within one hour of oral administration. Oral 250 mg BAPN at 6-hr intervals each day for 21 days resulted in urinary BAPN recoveries approximating 16% of the total dose. BAPN was not detected in urine in specimens collected later than 7 hr after cessation of BAPN dosage. Urinary CAA appeared more slowly than BAPN and increased gradually to approximately three times that of urinary BAPN. After BAPN was discontinued, there was prolonged urinary excretion of BAPN-derived CAA. These along with earlier findings in experimental animals suggest that unexcreted BAPN is sequestered in tissues where it is metabolized to CAA before slowly released.

Acetates↗
PubMed1978

Administration of beta-aminopropionitrile to human beings with urethral strictures: A prelimary report.

(1) No toxic signs or symptoms and no unusual laboratory determinations were observed in five patients with posterior urethral strictures treated by dilatation of the urethra and administration of 1 gm per day of beta-aminopropionitrile (BAPN) for twenty-one days. (2) Patients treated with 1 gm daily of BAPN for twenty-one days showed an increase in cold saline-extractable and acid-extractable collagen in proplast sponge-collected and dermal scar tissue comparable with that reported previously after doses of 3 to 5 gm of BAPN daily. (3) Significant reduction in the breaking strength of newly synthesized connective tissue was observed in patients treated with BAPN. (4) None of the patients in this study showed abnormalities in net collagen synthesis or in synthesis of noncollagenous protein. (5) The difference in the results of this study and two previous trials of BAPN in human beings which were discontinued because of toxic and or hypersensitivity signs and symptoms is hypothesized to be the result of development of highly purified BAPN fumarate.

Aminopropionitrile↗
PubMed1978

Pharmacological control of surgical scar tissue.

Pharmacological control of unwanted scar tissue theoretically is possible in human beings and has been proven to be practical and effective treatment in laboratory animals. The most advanced research involves prevention of the development of helical structure and transport of collagen by administration of proline analogues and controlled induction of lathyrism by administration of Beta-aminopropionitrile. The toxicity of proline analogues has prevented human testing; BAPN presently is being tested or has been tested in patients with scleroderma, flexor tendon adhesions, posterior urethral strictures, and surface keloids. At this time, highly purified BAPN appears generally non-toxic and is capable of exerting a higly selective and significant lathyrogenic effect on the healing wound. The combination of BAPN and other drugs, such as Colchicine, which increases collagenolytic activity, probably will make safe control of clinical properties of scar tissue possible within the next 24 months.

Aminopropionitrile↗