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Biomedical subjects

E E Johnson

Publications and source records attributed to E E Johnson.

At least 73 records · Page 4Linked to original sources
PubMed1988

Bone morphogenetic protein augmentation grafting of resistant femoral nonunions. A preliminary report.

Twelve patients with intractable nonunions of the femoral diaphyseal or metaphyseal-diaphyseal shaft were successfully treated by a combination of internal fixation and implants of human bone morphogenetic protein (h-BMP). There was an average of 4.3 surgical procedures per patient attempting union prior to h-BMP implantation. Union was obtained in 11 of 12 patients and in one patient with a repeat stabilization and implantation of h-BMP. Four patients received autogeneic cancellous bone graft and four patients received allogeneic bone grafts. The BMP implant was prepared in the form of an aggregate of h-BMP and bone matrix water-insoluble noncollagenous proteins (h-BMP/iNCP). Fifty to 100 mg of h-BMP/iNCP was either implanted in the fracture gap in ultra thin gelatin capsules, or incorporated in a strip of polylactic/polyglycolic acid copolymer (PLA/PGA) and placed as an onlay across the fracture gap. The average time to union was 4.7 months. Further clinical investigations are planned as a series of matched cases with and without BMP augmentation in order to distinguish h-BMP effects from new or improved methods of fracture fixation combined with autogeneic cancellous bone grafts.

Adolescent↗
PubMed1988

Combined direct and indirect reduction of comminuted four-part intraarticular T-type fractures of the distal femur.

Five patients with identical severely comminuted four-part intraarticular T-type fractures of the distal femur were treated with a combination of direct reduction of the condylar anatomy and indirect reduction of the metaphyseal fragments using a 95 degree blade plate and femoral distractor. In all patients there was a coronal-axial fracture of the medial condyle anterior to the origin of the posterior cruciate ligament (PCL) associated with disruption of the patellofemoral articulation (four-part fracture). There were no associated intraarticular or extraarticular knee ligament injuries with this specific fracture pattern. Following fracture stabilization all knees were stable. Anatomic reduction of the articular surface and restoration of alignment were obtained in every case. Functional results were rated as good to excellent in all patients.

Adult↗
PubMed1988

Custom titanium plating for failed nonunion or delayed internal fixation of femoral fractures.

Eight patients with either failed internal fixation of nonunions of the femur (six) or delayed treatment of extensively comminuted femoral fractures (two) were treated with customized titanium plates for internal fixation. All eight patients had fixation problems that surpassed treatment by intramedullary nailing or standard plate osteosynthesis. Custom titanium plates were individually designed from roentgenograms and/or computed axial tomographic (CAT) scans. Plate dimensions were altered to increase strength, height, length, and placement of screw holes to enhance stabilization of the individual femoral anatomy. At an average follow-up period of 33 months, all fractures united; there were no complications, including fatigue or loosening of the custom implants. The implants were well tolerated and provided excellent fixation of difficult fracture problems.

Adult↗
PubMed1987

Effect of norepinephrine on canine plasma concentrations of enkephalin-like material.

Norepinephrine (0.35 microgram/kg/min) was infused continuously for 20 min into either the carotid, femoral or superior mesenteric arteries of anesthetized, vagotomized and splenectomized dogs. Blood flow in these arteries was monitored continuously. Blood samples were taken from the aorta, jugular or femoral vein and the superior mesenteric and hepatic veins at 5-min intervals during a 20-min preinfusion period, the 20-min infusion period and a 20-min postinfusion interval. Blood samples were analyzed by radioimmunoassay with antibodies raised against Leu- and Met-enkephalin. Norepinephrine infused into the carotid or femoral arteries did not affect plasma levels of enkephalin-like material. By contrast, plasma concentrations of both Leu- and Met-enkephalin-like material were more than doubled during norepinephrine infusion into the superior mesenteric artery, P less than .001. This increase in enkephalin-like material occurred in arterial as well as venous blood. Neither infusion of vasopressin nor prostaglandin F2 alpha into the superior mesenteric artery elicited a rise in plasma levels of enkephalin-like material. In adrenalectomized dogs, when norepinephrine was infused into the superior mesenteric artery, there was again a statistically significant elevation in plasma concentrations of both Leu- and Met-enkephalin-like material.

Adrenalectomy↗
PubMed1987

Open intramedullary nailing and bone-grafting for non-union of tibial diaphyseal fracture.

Twenty consecutive patients who had non-union of twenty-two fractures (two of the patients had a segmental fracture) of the tibia underwent open reduction, débridement, and intramedullary nailing that was supplemented by bone-grafting with either autogenous cancellous iliac bone or cortical reamings of bone from the intramedullary canal. Eighteen patients had significant deformity associated with the tibial fracture. All but three patients had postoperative splinting for two to four weeks, followed by walking without a brace; the three patients who did not have postoperative splinting were more than sixty-five years old. All of the fractures went on to union. Two patients had a minor complication that did not affect the final result. Incorporation of callus across the site of non-union occurred at a rapid rate. Anatomical alignment of the tibial shaft was obtained in nineteen of the twenty patients.

Adolescent↗
PubMed1987

Multiplane correctional osteotomy of the tibia for diaphyseal malunion.

Multiplane correctional osteotomy of the tibia was performed on seven patients with diaphyseal malunion involving deformity in more than one plane. All patients had preoperative complaints related to either disturbances of gait, associated joint or back pain, or a cosmetically unacceptable extremity. Correction of length, varus/valgus, anterior/posterior bowing, and internal/external torsion were possible. Stabilization by standard AO principles of lag screw compression and neutralization plating provided rigid fixation and early functional rehabilitation. All patients healed without complication and all returned to unrestricted activity. Preoperative planing, meticulous surgical technique, appropriate wedge resection, and correct application of internal fixation are required to obtain excellent surgical results.

Adult↗
PubMed1987

Extrinsic femoral artery occlusion following internal fixation of an acetabular fracture. A case report.

Vascular injury is one of the drastic complications that can arise from internal fixation of acetabular fractures. A 29-year-old, obese man sustained multiple trauma, including a displaced transverse acetabular fracture. Extreme obesity made adequate exposure to the posterior acetabular area difficult, causing placement of a large lag screw in malposition, such that it penetrated the superior pubic ramus at a point adjacent to the superficial femoral artery. Angiography, immediately after operation, revealed extrinsic compression of this vessel. The lag screw was successfully repositioned, with immediate return of vessel patency and no sequelae. The surgical approach and anatomic landmarks for placement of posterior to anterior lag screws are reviewed in an effort to prevent this complication.

Accidents, Traffic↗
PubMed1986

Wellness center.

Explore the source record for details and available documents.

Aged↗
PubMed1984

New advances in bone research.

An edited summary of an Interdepartmental Conference arranged by the Department of Medicine, UCLA School of Medicine, Los Angeles. William M. Pardridge, MD, Associate Professor of Medicine, is Director of Conferences.

Bone Cements↗
PubMed1983

An ultrasound-induced tail-flick procedure: evaluation of nonsteroidal antiinflammatory analgesics.

An ultrasonic stimulus was used to elicit a nociceptive response (tail-flick) in mice. Acetaminophen, flurbiprofen, indomethacin, and zomepirac all produced an attenuation in the tail-flick response in a dose-related manner (100-400 mg/kg p.o.). Aspirin failed to significantly alter ultrasound-induced tail-flick latencies until the dose was raised to 700 mg/kg. Morphine (10 mg/kg, s.c.) produced the greatest attenuation in the tail-flick response, whereas chlorpromazine (20 mg/kg, p.o.) had no effect. The results indicate that this procedure can be used to evaluate analgesic drugs.

Animals↗
PubMed1983

Evaluation of four gentamicin and tobramycin assay procedures for clinical laboratories.

Accuracy, precision, and clinical laboratory utility of the TDX (Abbott Laboratories), Auto-ICS (Beckman Instruments, Inc.), COBAS-Bio (Roche Analytical Instruments, Inc.) with reagent kits (Syva), and EMIT (Syva) for gentamicin and tobramycin serum assay were assessed. TDX, COBAS-Bio, and EMIT analytical systems showed a proportional bias of less than 10% for recovery studies and a coefficient of variation less than 5% for within-run precision. The results of the recovery studies with the Auto-ICS showed a proportional bias of 25% with gentamicin and 16% with tobramycin. The within-run precision expressed as the coefficient of variation for the Auto-ICS was 6.7% for gentamicin and 8.6% for tobramycin. In comparisons involving gentamicin- and tobramycin-containing patient samples, the results with the TDX analytical system showed the best agreement with the COBAS-Bio. For the determination of these two antibiotics, the TDX analytical system provided the best overall accuracy and precision.

Gentamicins↗
PubMed1983

The contribution of the anterior talofibular ligament to ankle laxity.

The motion responses of thirty fresh-frozen cadaver tibiotalar joints were measured for applied anterior-posterior force, inversion-eversion moment, and internal-external rotary torque. The load-motion response curves obtained after sectioning the anterior talofibular ligament were compared with those for intact specimens in three positions of flexion of the ankle. Laxity of the intact ankle was shown to be dependent on flexion position; dorsiflexion was consistently the position of least laxity, reflecting the effects of talar geometry and its articulation with the tibiotalar syndesmosis. Section of the anterior talofibular ligament produced significant increases in laxity for all modes tested. Total anterior-posterior laxity increased by 4.3 millimeters in dorsiflexion, which was the position of maximum change. In contrast, the greatest increases in total inversion-eversion laxity (5.2 degrees) and total internal-external rotation laxity (10.8 degrees) were recorded in plantar flexion.

Adult↗