Biomedical subjects

E Dybkjaer

Publications and source records attributed to E Dybkjaer.

At least 37 records · Page 2Linked to original sources

PubMed1982

Identification of a cold agglutinin with anti-Pr3 specificity.

An apparent monoclonal IgM, kappa-cold agglutinin with anti-Pr specificity was detected in the serum of a 38-year old woman. Haemagglutination inhibition studies disclosed the subspecificity anti-Pr3, since the cold agglutinin was strongly inhibited by carbodiimide-treated erythrocyte glycoproteins. Studies with animal cells showed that the corresponding Pr3 determinant was found only on human red cells. This is in contrast to earlier findings and indicates that distinct fine specificities within anti-Pr3 antibodies might well exist.

Adult↗

PubMed1982

Circulating immune complexes in healthy persons.

The prevalence of circulating immune complexes (CIC) and C4 and C3 activation products (C4 and C3 A.P.) was investigated in sera from 106 blood donors, 100 hospital staff-members, 63 patients with rheumatoid arthritis and active synovitis, and in 25 hospital staff-members who had monthly tests performed during one year. CIC were detected by means of a complement consumption test and a polyethylene glycol precipitation test. C4 and C3 A.P. were demonstrated by means of crossed immunoelectrophoresis. No significant differences in the prevalence of CIC were found between blood donors and hospital staff-members (3 and 9%, respectively) and no age and sex differences were observed. In the longitudinal study of hospital staff-members, a significantly increased incidence of CIC was found during the winter months. CIC were found in 86% of the patients with rheumatoid arthritis. C4 and C3 A.P. were found significantly more often in sera with than without CIC. The significance of CIC detection may be increased by the simultaneous demonstration of C4 and C3 A.P. and by making allowance for seasonal variations.

Adolescent↗

PubMed1981

The prognosis of the healthy HBsAg carrier state. A 5- to 8-year follow-up study.

Thirty-six persons found to be healthy HBsAg carriers by routine donor screening from 1970 to 1973 were offered a follow-up examination in 1978. A total of 21 out of the 34 still living carriers were reexamined clinically, serologically, and biochemically. Seventeen of the 20 still HBsAg-positive carriers had anti-HBe, and 2 were HBeAg-positive. Liver biopsy in these two carriers showed chronic persistent hepatitis. No biochemical abnormalities were found in any but one who was HBeAg-positive and one who was negative for both HBeAg and anti-HBe. Anti-HBc titers varied between 1:3,600 and 1:83,000. Circulating immune complexes were demonstrated in 30% of the healthy HBsAg carriers. On the basis of 5-8 years' follow-up it is concluded that the healthy HBsAg carrier state is a benign condition that has not affected the carrier's quality of life. Progression to a severe, chronic liver disease was not observed in any of the healthy carriers. The importance and nature of circulating immune complexes in healthy HBsAg carriers was unknown and need further investigation.

Adult↗

PubMed1980