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Biomedical subjects

E Duranti

Publications and source records attributed to E Duranti.

28 records · Page 2Linked to original sources
PubMed1989

Serum B2 microglobulin (B2M) in CAPD.

Twenty-six chronic uremic pts (8F and 18M, mean age 64 yrs) on CAPD for 15 months on the average, were studied as regards the levels of B2M measured by radioimmunoassay in fasting serum samples. Considering residual renal function, 2 pts groups were identified: 11 pts with a diuresis greater than or equal to 500 cc/day and 15 pts with a diuresis less than 500 cc/day. Serum B2M was significantly decreased in the first group (24.8 +/- 8.1 vs 34.7 +/- 7.1 mg/l; p less than 0.02). Considering the incidence of peritonitis episodes, 12 pts without and 14 pts with one or more peritonitis episodes were noted. The group with no peritonitis showed significantly decreased serum B2M values (25.1 +/- 7.6 vs 35.03 +/- 4.8 mg/l; p less than 0.005). No relationship was found as regards primary renal diseases, sex and age of pts. We conclude that residual renal function and peritonitis episodes modify serum B2M levels in CAPD. The long term follow up of pts could be of interest for better defining the role of these factors as regards the incidence of pathologic lesions associated with B2M deposition.

Adult↗
PubMed1986

Acid secretion through the Rana esculenta skin: involvement of an anion-exchange mechanism at the basolateral membrane.

Kinetic and electrophysiological studies were carried out to characterize the efflux of HCO3- (or OH-) across the basolateral membrane of the proton-secreting cells of the frog skin epithelium bathed with dilute saline mucosal solutions. In control conditions, the acidification of the mucosal solution (JnH+) was correlated directly with serosal alkalinization. Cl- substitution in the serosal Ringer (by gluconate or methylsulphate ions) induced an inhibition of proton excretion (70% inhibition). Measurements of the basolateral membrane potential with conventional micro-electrodes and of cell Cl- activity (aCli) and proton activity with double-barrelled ion-sensitive micro-electrodes recorded a basolateral membrane depolarization of 5.1 +/- 0.7 mV (n = 12), a decrease in aCli from 14.5 +/- 1.6 mequiv l-1 to 1.8 +/- 0.3 mequiv l-1 (n = 12), and a cell pH increase from 7.18 +/- 0.04 to 7.32 +/- 0.06 (n = 12) after serosal Cl- replacement. 4,4'-diisothiocyanostilbene-2-2'-disulphonic acid (DIDS) (10(-4) M) and meclofenamate (5 X 10(-5) M) inhibit JHn+ by 34% and 53% respectively whereas bumetanide did not block JHn+. Depolarization of the basolateral membrane (2 mM-Ba2+ addition to the serosal solution) did not block proton excretion. We show that cell Cl- activity is maintained at a higher level than that predicted by the equilibrium potential, by a mechanism located at the basolateral membrane of the epithelium since the apical solution was Cl(-)-free. This mechanism is not sensitive to potential changes at the basolateral membrane in the range tested. An electroneutral Cl(-)-HCO3- exchange mechanism is the simplest hypothesis which can account for our results.

Animals↗
PubMed1983

[Aryloxy- and arylthioalkylamine hypolipidemic agents].

Aryloxy and arylthioalkylamines related respectively to clofibrate and 2-(3,5-di-t-butyl-4-hydroxyphenylthio)hexanoic acid, a derivative of an active probucol metabolite, were prepared and pharmacologically screened as hypolipidemic substances. Some of them showed interesting antilipemic activity but also, unfortunately, high acute toxicity.

Amines↗
PubMed1983

Study of inhibitor and nucleator activities in calcium stone formers.

In 30 calcium stone formers urinary citrate, magnesium, calcium, phosphorus, uric acid and oxalate excretion were compared with the activity product ratios and formation product ratios of oxalate, brushite and monosodium urate. A positive correlation was found between calcium and phosphorus excretions and APRox and APRbr; no correlation was found between oxalate, uric acid, citrate and magnesium excretion and APR or FPR. Thus calcium and phosphorus contribute significantly to the increments of urine saturation; citrate and magnesium do not modify the inhibitor urinary activity, and oxalate and uric acid do not influence inhibition and saturation activities of urine.

Adolescent↗